Long-acting antibacterial silicone rubber and preparation method thereof

A silicone rubber and long-acting technology, which is applied in the field of long-acting antibacterial silicone rubber and its preparation, can solve the problems of difficult to balance biocompatibility and long-acting antibacterial properties, and achieve strong binding force, stable chemical structure, and good application prospects Effect

Active Publication Date: 2021-01-29
SUZHOU DOBIOM MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial silicone rubber provided by the present invention and its preparation method solve the problem that the existing antibacterial silicone rubber is difficult to take into account the biocompatibility and long-acting antibacterial properties, and has a good application prospect

Method used

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  • Long-acting antibacterial silicone rubber and preparation method thereof
  • Long-acting antibacterial silicone rubber and preparation method thereof
  • Long-acting antibacterial silicone rubber and preparation method thereof

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preparation example Construction

[0064] As another aspect of the present invention, the present invention provides a kind of preparation method of long-acting antibacterial silicone rubber, comprising the steps:

[0065] S1. Soak the silicone rubber in one or more composite alcohol solutions containing 5%-20% vinyl silane coupling agent or methacryloxysilane coupling agent for 2-24 hours ( The reaction temperature is 30-60°C, 3cm 2 Silicone rubber plus 1mL reaction solution), ultrasonic cleaning after the reaction to obtain modified silicone rubber;

[0066] S2. Prepare a mixed aqueous solution containing imidazolium salt, initiator and polyvinyl or allyl compound, the concentration of imidazolium salt in the mixed aqueous solution is 0.2-2g / mL, and the mass of initiator is 0.01%-2% of the mass of imidazolium salt , the polyvinyl or allyl compound is 1%-10% of the imidazolium salt mole fraction;

[0067] S3. Soak the modified silicone rubber in S1 in the mixed aqueous solution in S2, and react under trigger...

Embodiment 1

[0089] A preparation method of long-acting antibacterial silicone rubber, comprising the steps of:

[0090] S1. Put the silicone rubber into the mixed solution of sulfuric acid and hydrogen peroxide (7:3 by volume), soak for 1 minute, take out the silicone rubber, wash and dry it, then soak the silicone rubber in a solution containing 15% γ-methacrylic acid In an ethanol solution of acyloxypropyltriethoxysilane, react at 50°C for 18 hours, take out the silicone rubber, ultrasonically clean it and dry it to obtain a modified silicone rubber;

[0091] S2. Dissolving 1-allyl-3-butylimidazolium tetrafluoroborate, azobisisobutamidine hydrochloride, and 1,3-propanediol diacrylate in deionized water respectively, and preparing a functional reaction solution, The concentration of 1-allyl-3-butylimidazole tetrafluoroborate in aqueous solution is 1.3g / mL, and the mass of azobisisobutyramide hydrochloride is 1-allyl-3-butylimidazole 0.5% of the quality of tetrafluoroborate, 1,3-propaned...

Embodiment 2

[0094] A preparation method of long-acting antibacterial silicone rubber, comprising the steps of:

[0095] S1. Soak the silicone rubber in an ethanol solution containing 20% ​​vinyl tris(2-methoxyethoxy)silane, react at 30° C. for 24 hours, take out the silicone rubber and ultrasonically clean it and dry it to obtain a modified silicone rubber;

[0096] S2. Dissolve 1-vinyl-3-ethylimidazolium chloride salt, potassium persulfate, and N,N-methylenebisacrylamide in deionized water in sequence to configure a functional reaction solution. 1-vinyl-3-ethyl The mass concentration of imidazolium chloride salt in aqueous solution is 1.2g / mL, the mass of potassium persulfate is 0.01% of the mass of 1-vinyl-3-ethylimidazolium chloride salt, and the molar amount of N,N-methylenebisacrylamide The number is 8% of the moles of 1-vinyl-3-ethylimidazolium chloride salt;

[0097] S3. Soak the silicone rubber in S1 in the functional reaction solution of S2, irradiate with ultraviolet light, and...

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Abstract

The invention discloses a long-acting antibacterial silicone rubber and a preparation method thereof, the surface of the silicone rubber is bonded with a compact cross-linked network-shaped polyimidazole layer, and the thickness of the cross-linked network-shaped polyimidazole layer is 1-30 [mu] m. According to the long-acting antibacterial silicone rubber and the preparation method thereof, the problem that the biocompatibility and the long-acting antibacterial property of existing antibacterial silicone rubber are difficult to consider in a physiological environment is solved, and the long-acting antibacterial silicone rubber has a relatively good application prospect.

Description

technical field [0001] The invention relates to the field of medical silicone rubber materials, in particular to a long-acting antibacterial silicone rubber and a preparation method thereof. Background technique [0002] Silicone rubber has excellent biological safety and chemical inertness, and has been widely used in medical devices for implantation or interventional therapy, such as urinary catheters, drainage tubes, respiratory catheters, cervical occluders, wound dressings and other fields. However, as an exogenous artificial material, the surface of silicone rubber is prone to bacterial adhesion and proliferation during implantation / intervention, and as the implantation time increases, bacterial adhesion and infection are more likely to occur, and even biofilms are formed on the surface. The implant material needs to be replaced, causing a huge burden on medical workers and patients. According to statistics, the bacterial infection caused by the use of silicone rubber...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08J7/12C08L83/04
CPCC08J7/16C08J7/123C08J7/12C08J2383/04
Inventor 林香云牛之猛肖启波蔡衫
Owner SUZHOU DOBIOM MEDICAL TECH CO LTD
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