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Adhesive and efficient hemostatic microspheres and preparation method thereof

A microsphere and high-efficiency technology, applied in the field of medical devices, can solve the problems of uncontrollable release of hemostatic agent and blood coagulation, and achieve the effect of low price, fast hemostasis and high water absorption rate

Active Publication Date: 2022-04-26
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no chemical and physical interaction between the hemostat and the sponge, and the release of the hemostat from the sponge is uncontrollable, which may lead to hemostatic-induced coagulation in other parts of the organism

Method used

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  • Adhesive and efficient hemostatic microspheres and preparation method thereof
  • Adhesive and efficient hemostatic microspheres and preparation method thereof
  • Adhesive and efficient hemostatic microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An adhesive high-efficiency hemostatic microsphere and a preparation method thereof, mainly comprising the following steps:

[0028] (1) Preparation of sodium alginate grafted with dopamine: Sodium alginate was dissolved in PBS buffer solution, under the protection of nitrogen, passed through (1-(3-dimethylaminopropyl)-3-ethylcarbodi imine hydrochloride) and N-hydroxysuccinimide (NHS) are activated, and dopamine is added to obtain sodium alginate grafted with dopamine.

[0029](2) Preparation of water phase: Dissolve carboxymethyl chitosan and dopamine-grafted sodium alginate in nitrogen-purified deionized water, and stir evenly to obtain a uniform water phase solution with a concentration of 2% in which carboxymethyl The mass ratio of chitosan to dopamine-grafted sodium alginate is 2:3.

[0030] (3) Preparation of the oil phase: Add Span-60 to the liquid paraffin, stir and emulsify at a stirring speed of 300 rpm for 1 hour and mix evenly to obtain the oil phase. Span-...

Embodiment 2

[0036] An adhesive high-efficiency hemostatic microsphere and a preparation method thereof, mainly comprising the following steps:

[0037] (1) Preparation of hyaluronic acid grafted with dopamine: hyaluronic acid was dissolved in PBS buffer solution, under the protection of nitrogen, passed through (1-(3-dimethylaminopropyl)-3-ethylcarbodi imine hydrochloride) and N-hydroxysuccinimide (NHS) are activated, and dopamine is added to obtain hyaluronic acid grafted with dopamine.

[0038] (2) Preparation of the aqueous phase: Dissolve aminated carboxymethyl chitosan and dopamine-grafted hyaluronic acid in deionized water, stir evenly, and obtain a uniform aqueous phase solution with a concentration of 5%, in which the aminated carboxymethyl chitosan The mass ratio of chitosan to dopamine-grafted hyaluronic acid is 2:3.

[0039] (3) Preparation of the oil phase: Add Span-80 to the liquid paraffin, stir and emulsify at a stirring speed of 200 rpm for 0.5 h and mix evenly to obtain ...

Embodiment 3

[0045] An adhesive high-efficiency hemostatic microsphere and a preparation method thereof, mainly comprising the following steps:

[0046] (1) Preparation of dopamine-grafted gelatin: gelatin was dissolved in PBS buffer solution, under the protection of nitrogen, passed through (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Salt) and N-hydroxysuccinimide (NHS) are activated, and dopamine is added to obtain gelatin grafted with dopamine.

[0047] (2) Preparation of the aqueous phase: Dissolve the aminated carboxymethyl chitosan and dopamine-grafted gelatin in deionized water, and stir evenly to obtain a uniform aqueous solution with a concentration of 2.5%, in which the aminated carboxymethyl chitosan The mass ratio of glycan to dopamine-grafted gelatin is 2:3.

[0048] (3) Preparation of oil phase: Add Span-60 to petroleum ether, stir and emulsify at a stirring speed of 250 rpm for 3 h and mix well to obtain an oil phase. Span-60 is 0.3% of petroleum ether;

...

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Abstract

The invention relates to an adhesive high-efficiency hemostatic microsphere and a preparation method thereof. The method relates to the field of medical equipment, and the preparation method is as follows: stirring and mixing a natural macromolecule grafted with dopamine and a macromolecular substance containing amino groups in a certain proportion to form a Uniform liquid, microspheres with a certain particle size and a three-dimensional network structure are prepared by reverse-phase suspension polymerization and emulsification cross-linking technology. Then, the hemostatic agent sodium carsulfone is adsorbed on the surface of the microspheres by means of electrostatic interaction, and finally dried to obtain the hemostatic microspheres capable of adhering to and loading the hemostatic agent. The hemostatic microspheres control the three-dimensional network structure of the hemostatic microspheres by adjusting the degree of cross-linking to achieve enhanced water absorption rate and water absorption speed. The dopamine on the surface achieves strong adhesion to the wound to block the wound and the hemostatic agent on the surface of the hemostatic microspheres can accelerate endogenous hemostasis process. Therefore, the synergistic effect of the three hemostatic methods of the hemostatic microsphere achieves the effect of rapid hemostasis, and the preparation method of the present invention is simple, has no pollution to the environment, has low production cost, and has broad application prospects.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an adhesive high-efficiency hemostatic microsphere and a preparation method thereof. Background technique [0002] Uncontrollable bleeding is an important cause of death in wars and traffic accidents, and it is also an inevitable problem in surgical operations. According to statistics, timely hemostasis at the initial stage of blood loss can reduce 30% of deaths. And wherein 80% of the deaths are because the wound is not located in the compression hemostasis, for example, chest, abdomen, head, neck and so on. Therefore, controlling bleeding through rapid and effective methods is the key to reducing the death caused by bleeding. [0003] Different hemostatic materials, such as gauze, bandage, sponge, are widely used in the treatment of surgical procedures or external bleeding. However, these hemostatic agents are not suitable for application on irregular wounds, intraca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08L5/04C08L5/08C08L89/00C08L1/08A61L24/00A61L24/08A61L24/10
CPCC08J3/246A61L24/08A61L24/104A61L24/0015A61L24/0036A61L24/001C08J2305/04C08J2305/08C08J2389/00C08J2405/08C08J2489/00C08J2301/08A61L2300/216A61L2300/418A61L2400/04C08L5/08C08L5/04C08L1/286
Inventor 张海军车超越袁坤山张淑欣侯文博尹玉霞鲁手涛段翠海
Owner SHANDONG BRANDEN MEDICAL DEVICE
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