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Titanium dioxide-gold nanorod asymmetric nano composite material as well as preparation method and application thereof

A technology of nanocomposite materials and gold nanorods, which is applied in the field of photothermal and photodynamic synergistic therapy of hypoxic tumors, can solve the problems of poor growth conditions of gold nanorods, and achieve good biocompatibility

Pending Publication Date: 2021-02-05
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the harsh growth conditions of gold nanorods, titanium dioxide nanorods can only be regenerated as seeds on gold nanorods.

Method used

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  • Titanium dioxide-gold nanorod asymmetric nano composite material as well as preparation method and application thereof
  • Titanium dioxide-gold nanorod asymmetric nano composite material as well as preparation method and application thereof
  • Titanium dioxide-gold nanorod asymmetric nano composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A specific synthesis method of composite nanoparticles for photothermal and photodynamic synergistic therapy of hypoxic tumors.

[0037] Synthesis of gold nanorods:

[0038] 10 volume C 16 TAB (0.1M) solution was mixed with 0.1 volume of chloroauric acid solution (25mM) in a 20 volume reaction flask, then stirred evenly at room temperature, and 1 volume of freshly prepared 100mM NaBH was added 4 The solution (ice-cooled) was quickly injected into the solution mixture. The solution was stirred rapidly for 2 minutes, and left to age at room temperature for later use.

[0039] 3.6g C 16 TAB was dissolved in 100 volumes of deionized water to prepare a growth solution of gold nanorods in a 250 volume Erlenmeyer flask. After cooling, 5 volumes of silver nitrate (4 mM) were added. The mixture was kept at room temperature for 15 minutes, then 10 volumes of chloroauric acid solution (1 mM) were added. Then the mixture became colorless, and after stirring well, 0.89 volume ...

Embodiment 2

[0045] Synthesis of gold nanorods:

[0046] 1 volume C 16 TAB (0.1M) solution was mixed with 0.01-0.2 volume of chloroauric acid solution (25mM) in a 20-volume reaction vial, then stirred at 30°C for 5 minutes, and 0.06-0.1 volume of freshly prepared 100mM NaBH was added 4 The solution (ice-cooled) was quickly injected into the solution mixture. The solution was stirred rapidly for 2 minutes, and aged at 30°C for 30 minutes.

[0047] Will C 16 TAB was dissolved in a certain amount of deionized water (50 °C), and a growth solution of gold nanorods was prepared in an Erlenmeyer flask. After cooling to 30°C, 1 volume of silver nitrate (4mM) was added. The mixture was kept at 30° C. for 15 minutes, then 1.5-2 volumes of chloroauric acid solution (1 mM) were added. The mixture then became colorless, and after stirring for 90 minutes (700 rpm), 0.2 volume of hydrochloric acid (37 wt% in water, 12.1 M) was added to adjust the pH of the mixture. After stirring slowly for another...

Embodiment 3

[0053] A specific synthesis method of composite nanoparticles for photothermal and photodynamic synergistic therapy of hypoxic tumors.

[0054] Synthesis of gold nanorods:

[0055] 10 volume C 16 TAB (0.1M) solution was mixed with 0.1 volume of chloroauric acid solution (25 mM) in a 20 volume reaction vial, then stirred at room temperature for 5 minutes, and 1 volume of freshly prepared 100 mM NaBH was added 4 The solution (ice-cooled) was quickly injected into the solution mixture. The solution was stirred rapidly for 2 minutes, and left to age at room temperature for later use.

[0056] 7.2g C 16 TAB was dissolved in 200 volumes of deionized water (50 °C) and a growth solution of gold nanorods was prepared in a 250 volume Erlenmeyer flask. After cooling to 30°C, 10 volumes of silver nitrate (4mM) were added. The mixture was kept at 30° C. for 15 minutes, then 20 volumes of chloroauric acid solution (1 mM) were added. The mixture then became colorless, and after stirrin...

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Abstract

The invention discloses a titanium dioxide-gold nanorod asymmetric nano composite material as well as a preparation method and application thereof. The nano composite material has an asymmetric structure that titanium dioxide is in direct contact with one end of a gold nanorod by taking one end of the gold nanorod as a growing point of the nano titanium dioxide, wherein the length-diameter ratio of the gold nanorod is about 2.5-3.5, and the thickness of the titanium dioxide in direct contact is 7-20 nanometers; nano composite particles have relatively good tumor permeability due to small sizeand are absorbed in a near-infrared light region of 650-900 nanometers with relatively strong penetrating power, and PEG and fluorescent molecules-PEG are used for surface modification to enhance thebiocompatibility. The material can be used for near-infrared illumination based suitable photothermal and better photodynamic synergistic treatment of hypoxic tumors; and a synthesis method of the nano composite particles has the advantages of convenience in operation, cheap raw materials, simplicity in separation and the like.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to an asymmetric nanocomposite material of titanium dioxide-gold nanorods, its preparation method and its application in photothermal and photodynamic synergistic therapy of hypoxic tumors. Background technique [0002] In recent years, near-infrared-based phototherapy technologies, mainly including photothermal therapy and photodynamic therapy, have shown good accuracy, high efficiency, deep tissue penetration, minimally invasive surgery, and small side effects in tumor treatment, and have been favored. Widely developed. Among them, photothermal therapy uses photothermal agents (such as gold nanoparticles, polyaniline nanoparticles, carbon nanotubes, polypyrrole nanoparticles, etc.) to realize radiation heating of tumors through the transmission of near-infrared light for rapid ablation. However, local excessive temperature may cause heat shock response and destroy normal ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/54A61K47/60A61P35/00C01G23/053B82Y40/00B82Y30/00B82Y5/00B22F9/24
CPCA61K41/0052A61K41/0057A61K47/545A61K47/60A61P35/00C01G23/0536B82Y40/00B82Y30/00B82Y5/00B22F9/24C01P2004/80C01P2004/64A61K2300/00
Inventor 杜健军葛浩英龙飒然樊江莉彭孝军
Owner DALIAN UNIV OF TECH
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