Pingyangmycin-containing nanoemulsion contrast therapeutic agent and preparation process thereof

A technology of Pingyangmycin and its preparation process, which is applied in the preparation of X-ray contrast agents, general/multifunctional contrast agents, preparations for in vivo tests, etc. It can solve the problems of life-threatening and high cancer mortality, and achieve the improvement of contrast effect , remarkable effect and reasonable structural design

Inactive Publication Date: 2021-02-05
THE AFFILIATED HOSPITAL OF GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the field of medical imaging, molecular imaging technology can provide important information for the diagnosis and monitoring of diseases in living tissues, and thus has received extensive attention and practical application. Imaging technology plays an important role in early cancer detection, and the mortality rate of cancer is relatively low. It is relative

Method used

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  • Pingyangmycin-containing nanoemulsion contrast therapeutic agent and preparation process thereof
  • Pingyangmycin-containing nanoemulsion contrast therapeutic agent and preparation process thereof
  • Pingyangmycin-containing nanoemulsion contrast therapeutic agent and preparation process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035]A nanoemulsion contrast treatment agent containing Pingyangmycin, comprising: 70 parts of superparamagnetic nanoparticles, 400 parts of iodized oil, 135 parts of medical compound gelatin, 1 part of Pingyangmycin, 15 parts of serum white egg white, 5 parts emulsifier.

[0036] Wherein, the superparamagnetic nanoparticles are Fe 2 o 3 Nanoparticles are obtained by evaporation method, and the diameter of the superparamagnetic nanoparticles is 3nm.

[0037] The Fe 2 o 3 Nanoparticles are encapsulated within the emulsified lipiodol emulsion droplets.

[0038] The medical composite gelatin comprises bone pharmaceutical gelatin and skin pharmaceutical gelatin with a mass ratio of 10:3.

[0039] The iodine content of the iodized oil is 100mg / ml.

[0040] The serum albumin is combined on the emulsion droplet made of the medical compound gelatin, and the pingyangmycin is combined on the serum albumin.

[0041] The emulsifier includes 50 parts of surfactant and 1 part of co-...

Embodiment 2

[0045] A nanoemulsion contrast treatment agent containing pingyangmycin, comprising: 80 parts of superparamagnetic nanoparticles, 450 parts of iodized oil, 155 parts of medical compound gelatin, 2 parts of pingyangmycin, 20 parts of serum white egg white, 8 parts emulsifier.

[0046] Wherein, the superparamagnetic nanoparticles are Fe 2 o 3 Nanoparticles, which are obtained by evaporation method, the diameter of the superparamagnetic nanoparticles is 7nm.

[0047] The Fe 2 o 3 Nanoparticles are encapsulated within the emulsified lipiodol emulsion droplets.

[0048] The medical composite gelatin comprises bone pharmaceutical gelatin and skin pharmaceutical gelatin with a mass ratio of 10:3.

[0049] The iodine content of described iodized oil is 125mg / ml.

[0050] The serum albumin is combined on the emulsion droplet made of the medical compound gelatin, and the pingyangmycin is combined on the serum albumin.

[0051] The emulsifier includes 55 parts of surfactant and 1....

Embodiment 3

[0055] A nanoemulsion contrast treatment agent containing pingyangmycin, comprising: 90 parts of superparamagnetic nanoparticles, 500 parts of iodized oil, 175 parts of medical compound gelatin, 3 parts of pingyangmycin, 25 parts of serum white egg white, 10 parts emulsifier.

[0056] Wherein, the superparamagnetic nanoparticles are Fe 2 o 3 Nanoparticles, which are obtained by evaporation method, the diameter of the superparamagnetic nanoparticles is 10nm.

[0057] The Fe 2 o 3 Nanoparticles are encapsulated within the emulsified lipiodol emulsion droplets.

[0058] The medical composite gelatin comprises bone pharmaceutical gelatin and skin pharmaceutical gelatin with a mass ratio of 10:3.

[0059] The iodine content of described iodized oil is 150mg / ml.

[0060] The serum albumin is combined on the emulsion droplet made of the medical compound gelatin, and the pingyangmycin is combined on the serum albumin.

[0061] The emulsifier includes 60 parts of surfactant and ...

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Abstract

The invention discloses a pingyangmycin-containing nanoemulsion radiography therapeutic agent and a preparation process thereof. The pingyangmycin-containing nanoemulsion radiography therapeutic agentcomprises 70-90 parts of superparamagnetic nanoparticles, 400-500 parts of iodized oil, 135-175 parts of medical composite gelatin, 1-3 parts of pingyangmycin, 15-25 parts of serum albumin and 5-10 parts of an emulsifier, wherein the superparamagnetic nanoparticles are Fe2O3 nanoparticles, and are obtained through a steaming method; the diameter of the superparamagnetic nanoparticles is 3-10 nm;the Fe2O3 nanoparticles are wrapped in the emulsified iodized oil emulsion droplets; the medical composite gelatin comprises gelatin for bone pharmacy and gelatin for skin pharmacy according to a massratio of 10: 3; the iodine content of iodized oil is 100-150 mg/ml; the serum albumin is combined with the emulsion droplets prepared from the medical composite gelatin; and the pingyangmycin is combined on the serum albumin.

Description

technical field [0001] The invention relates to the technical field of medical imaging, in particular to a nanoemulsion imaging treatment agent containing pingyangmycin and a preparation process thereof. Background technique [0002] In the field of medical imaging, molecular imaging technology can provide important information for the diagnosis and monitoring of diseases in living tissues, and thus has received extensive attention and practical application. Imaging technology plays an important role in early cancer detection, and the mortality rate of cancer is relatively low. It is relatively high and seriously threatens human life. The earlier the signs of cancer are detected, the higher the patient's cure rate is relatively. However, early tumors are usually small, and the size is usually below 1cm. Such as computed tomography (CT), magnetic resonance imaging (MRI), X-ray, and ultrasound (US), etc., it is difficult to accurately diagnose the tiny tumor; [0003] Multimo...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/18A61K49/04A61K9/107A61K47/42A61K38/14A61P35/00
CPCA61K49/0002A61K49/1806A61K49/0438A61K9/1075A61K47/42A61K38/14A61P35/00
Inventor 周石黄智曾柱
Owner THE AFFILIATED HOSPITAL OF GUIZHOU MEDICAL UNIV
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