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Metal hydroxide complex comprising active component and modified multilayered hydroxide structure, and method for preparing same

A hydroxide and active ingredient technology, applied in the field of metal hydroxide complexes and their preparation, can solve the problems of reducing the effect of active ingredients, excluding active materials, and time-consuming active substances, achieving improved effects, minimizing irritation, The effect of excellent sustained release properties

Pending Publication Date: 2021-02-23
CNPHARM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the foregoing methods are time-consuming due to complicated methods, processes, etc. for handling active substances, and thus are not economical
In addition, since the coating of the active ingredient has to be additionally performed, the effect of the individual active ingredient is reduced, which has the problem of not including an excess of active material in the complex

Method used

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  • Metal hydroxide complex comprising active component and modified multilayered hydroxide structure, and method for preparing same
  • Metal hydroxide complex comprising active component and modified multilayered hydroxide structure, and method for preparing same
  • Metal hydroxide complex comprising active component and modified multilayered hydroxide structure, and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Synthesis Example 1: Preparation 1 of a multi-layered metal hydroxide crystal in which vitamin C (ascorbic acid) is inserted into the layers between layers of metal salts

[0098] 30g ZnO and 1197mL without carbonate ion (CO 3 2- ) of deionized water in the main reaction tank, stirring (400rpm) at room temperature under a nitrogen atmosphere, concentrated hydrochloric acid solution was slowly added dropwise to it, and its pH was titrated to a range of 0.5 to 1. Dissolve 26g of vitamin C in 230mL of deionized water and 175mL of ethanol in auxiliary tank 1, and add the vitamin C solution in auxiliary tank 1 into the main tank, and stir for 30min in a nitrogen atmosphere. While maintaining the stirring rate (700rpm) of the main tank, add 5M aqueous sodium hydroxide solution from the auxiliary tank 2 to titrate the pH to a range of about 6.5 to 7.5, and then initiate the precipitation reaction under stirring (700rpm) 3 hours. After the reaction, the measured pH was 6...

Embodiment 2

[0099] Synthesis Example 2: Preparation 2 of multilayer metal hydroxide crystals, in which vitamin C is inserted into layered metal salts between layers

[0100] 30gZnO, 549mL without carbonate ion (CO 3 2- ) of deionized water and 628mL of ethanol (>98%) in the main reaction tank, stirred (400rpm) at room temperature under nitrogen atmosphere, concentrated hydrochloric acid solution was slowly added dropwise to it, and its pH was titrated to 0.5 to 1 range. Dissolve 26g of vitamin C in 230mL of deionized water and 175mL of ethanol in auxiliary tank 1, and add the vitamin C solution in auxiliary tank 1 into the main tank, and stir for 30min in a nitrogen atmosphere. While maintaining the stirring rate (700rpm) of the main tank, add 5M aqueous sodium hydroxide solution from the auxiliary tank 2 to titrate the pH to a range of about 6.5 to 7.5, and then initiate the precipitation reaction under stirring (700rpm) 3 hours. After the reaction, the pH was measured to be 6.5 ...

Embodiment 3

[0102] Synthesis Example 3: Preparation 3 of a multilayer metal hydroxide crystal in which vitamin C is inserted between layers of a layered metal salt

[0103] 30gZnO, 254mL without carbonate ion (CO 3 2- ) of deionized water and 943mL of ethanol (>98%) in the main reaction tank, stirred (400rpm) at room temperature under nitrogen atmosphere, concentrated hydrochloric acid solution was slowly added dropwise to it, and its pH was titrated to 0.5 to 1 range. Dissolve 26g of vitamin C in 230mL of deionized water and 175mL of ethanol in auxiliary tank 1, and add the vitamin C solution into the main tank, and stir for 30min in a nitrogen atmosphere. While maintaining the stirring rate (700rpm) of the main tank, add 5M aqueous sodium hydroxide solution from the auxiliary tank 2, titrate the pH to a range of about 6.5 to 7.5, and then initiate the precipitation reaction under stirring (700rpm) 3 hours. After the reaction, the pH was measured to be 6.5 to 7.0, and after the react...

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Abstract

Provided are a metal hydroxide complex comprising a base layer, a surface layer, and an active component, the metal hydroxide complex comprising a multilayered hydroxide structure of chemical formula1; a metal hydroxide complex prepared by including a step of co-precipitating, through a precipitation reaction, the active component and a precursor of a metal hydroxide structure using alcohol and water; and a method for preparing same.

Description

technical field [0001] The present invention relates to a metal hydroxide composite comprising a modified multilayer hydroxide structure comprising a base layer, a surface layer and an active ingredient and a method for preparing the same. Background technique [0002] Active ingredients of cosmetics that can be applied to the skin and can directly exhibit their effects may include vitamins and the like. Vitamins are essential substances in the body, which have the ability to promote the metabolism of living organisms, exhibit antioxidant effects, protect cell walls, enhance immunity, increase resistance to infection, etc., and in most primates, vitamin biosynthesis cannot be performed , intake through food is essential, and insufficient intake of vitamins can cause multivitamin deficiency. In addition, in skin beauty and treatment, vitamins play a very important role in maintaining healthy skin, such as preventing pigmentation, promoting collagen synthesis, blocking ultrav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/19
CPCC07F3/02C07F3/04C07F3/06Y02E60/10A61K8/0283A61K8/0258A61K8/19A61K2800/58A61K2800/805
Inventor 金镐浚金姬妍
Owner CNPHARM
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