Metformin hydrochloride and glibenclamide composition and preparation method thereof

Abstract

The invention relates to a metformin hydrochloride and glibenclamide composition. The metformin hydrochloride and glibenclamide composition is prepared from, by weight, 1.25-2.5mg of glibenclamide, 250-500mg of metformin hydrochloride, 250-500mg of hydroxypropyl methylcellulose acetate succinate, 3-5mg of sodium hydroxide and 12.5-25mg of low-substituted hydroxypropyl cellulose. The metformin hydrochloride and glibenclamide composition further comprises an adjuvant. The invention further discloses a preparation method. The metformin hydrochloride and glibenclamide composition has the advantages of being high in dissolution rate, few in impurity and high in effective medicine content.

Description

technical field

[0001] The invention relates to the field of chemical medicine, in particular to a metformin glibenclamide composition and a preparation method thereof. Background technique

[0002] Diabetes is the chronic disease with the largest number of patients in my country, and it is tending to be younger. Diabetes is a group of clinical syndromes caused by the interaction of genetic and environmental factors. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissue cells to insulin lead to a series of metabolic disorders such as sugar, protein, fat, water and electrolytes. Clinically, hyperglycemia is the main sign, and prolonged illness can cause damage to multiple systems. Acute metabolic disorders such as ketoacidosis can occur in severe illness or stress.

[0003] Metformin glibenclamide compound preparations have already been on the market in China, and there are two specifications: 250mg containing metformin hydrochl...

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