Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Avibactam and beta-lactam antibiotic compound synergistic composition

A technology of lactams and antibiotics, which is applied in the research and development field of pesticide compounding, can solve the problems of loss of inhibitory effect, high dosage, self-structural damage, etc., and achieve the effects of high inhibition efficiency, delaying rapid degradation, and reducing control costs

Inactive Publication Date: 2021-03-09
GUANGXI ZHUANG AUTONOMOUS REGION ACAD OF AGRI SCI
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, β-lactam antibiotics are commonly used in combination with β-lactamase inhibitors, such as tazobactam and clavulanic acid, which form a non-covalent Michaelis complex with β-lactamase, and then undergo rearrangement etc. inactivate the enzyme, but its own structure is also destroyed, thus losing its inhibitory effect, so conventional β-lactamase inhibitors such as tazobactam and clavulanic acid and β-lactam antibiotics require higher doses , repeated use can play a preventive role

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Avibactam and beta-lactam antibiotic compound synergistic composition
  • Avibactam and beta-lactam antibiotic compound synergistic composition
  • Avibactam and beta-lactam antibiotic compound synergistic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 90% Avibactam Amoxicillin Sodium Wettable Powder, which is the sum of the mass of Avibactam and Amoxicillin Sodium and accounts for 90% of the total mass of the whole preparation, which is composed of the following mass percentage raw materials: Avibactam 10%, amoxicillin sodium 80%, calcium hydrogen phosphate 3% and sodium stearate 7% are uniformly obtained by stirring.

Embodiment 2

[0025] 60% Avibactam Ampicillin Sodium Wettable Powder, the sum of the mass of Avibactam and Ampicillin Sodium accounts for 60% of the total mass of the whole preparation, which is composed of the following mass percentage raw materials: Avibactam 5% , 55% of sodium ampicillin, 7% of sodium lignosulfonate, 5% of chitosan oligosaccharide, 10% of calcium hydrogen phosphate and 18% of white carbon black are prepared by stirring uniformly.

Embodiment 3

[0027] 90% Avibactam·Ceftazidime Capsules, the sum of the mass of Avibactam and Ceftazidime accounts for 90% of the total mass of the whole preparation, and it is composed of the following mass percentage raw materials: Avibactam 10%, Ceftazidime 80%, 5% of chitosan, 3% of polyethylene glycol and 2% of ascorbic acid are prepared by conventional capsule-making process.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an avibactam and beta-lactam antibiotic compound synergistic composition which comprises avibactam and beta-lactam antibiotics, and the mass ratio of the avibactam to the beta-lactam antibiotics is 1: 80-40: 1. The avibactam and beta-lactam antibiotic compound composition disclosed by the invention has an obvious synergistic effect, overcomes and delays rapid degradation ofbetalactam antibiotics in plants, reduces the application dosage and frequency, and obviously improves the prevention and treatment effect on citrus yellow shoot.

Description

technical field [0001] The invention relates to the field of pesticide compound research and development. More specifically, the present invention relates to a synergistic composition of Avibactam (Avibactam) and β-lactam antibiotics for preventing and treating citrus Huanglongbing. Background technique [0002] Citrus is the most important fruit tree in the world and is grown in 135 countries and regions around the world. China has become the world's largest citrus producer and exporter. Chinese citrus is grown in 19 provinces (autonomous regions and municipalities) including Guangxi, Hunan, Hubei, Sichuan, Jiangxi, Fujian, Chongqing, Zhejiang, Yunnan and Guizhou. Citrus Huanglongbing (HLB) is considered worldwide as a devastating infectious bacterial disease of the citrus industry. Psyllids spread by piercing and sucking citrus fruit trees with poison, and are now widely distributed in many countries and regions such as Asia, America, and Africa. It mainly threatens fam...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/40A01N43/90A01P1/00
CPCA01N43/40A01N43/90
Inventor 劳水兵刘丽辉迟海军莫仁甫覃国新杨玉霞周其峰李慧玲何洁罗丽红
Owner GUANGXI ZHUANG AUTONOMOUS REGION ACAD OF AGRI SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com