Compound, nitric oxide donor prodrug compound as well as preparation method and application of compound and nitric oxide donor prodrug compound
A technology of nitric oxide and compounds, applied in the field of nitric oxide donor prodrug compounds and their preparation, can solve the problems of non-specific hydrolysis of endogenous glycosides, unpredictable physiological consequences, blood pressure drop, etc., to improve the target tropism, avoid non-specific degradation, and improve stability
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[0056] 1. Synthesis of azoenol donor compound (Cel2-NONOate) with cellobioside modification
[0057] (1) Weigh cellobiose (5.00g, 14.6mmol) in a 100mL three-necked flask, under nitrogen protection, add anhydrous pyridine (30mL), use a constant pressure dropping funnel, add dropwise acetic anhydride ( 18 mL), after the addition was complete, the ice bath was removed and stirred at room temperature for 12 h. The reactant disappears. Spin the solvent with an oil pump, add 100mL DCM dichloromethane to dilute, then wash with saturated CuSO 4 (100mL×2), washed with saturated brine (100mL). Anhydrous Na for organic phase 2 SO 4 Dry, filter and spin the filtrate. 7.0 g of white solid powder of fully acetylated cellobiose was obtained, with a yield of 70%.
[0058] (2) Weigh fully acetylated cellobiose (7.0 g, 10.3 mmol) and dissolve it in acetic anhydride (7 mL). 33% HBr / AcOH solution (17.5 mL) was slowly added dropwise with stirring in an ice bath, shielded from light, the ice...
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