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Tannic acid pyridine quaternary ammonium salt as well as preparation method and application thereof

A technology of pyridine tannic acid and quaternary ammonium salt, applied in the directions of botanical equipment and methods, application, preparation of sugar derivatives, etc., can solve the problems of bacterial drug resistance, toxic reaction, allergic reaction, etc., and achieve bacteriostatic effect The effect of improving, improving biocompatibility, and improving antibacterial activity

Active Publication Date: 2021-03-12
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current method of treating bacterial infection is mainly the application of antibiotics, which has the advantages of fast curative effect, broad-spectrum antibacterial and bactericidal, but long-term or high-dose use of antibiotics will cause adverse reactions such as allergic reactions, toxic reactions, and specific reactions, and the abuse of antibiotics is also harmful. bacterial resistance

Method used

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  • Tannic acid pyridine quaternary ammonium salt as well as preparation method and application thereof
  • Tannic acid pyridine quaternary ammonium salt as well as preparation method and application thereof
  • Tannic acid pyridine quaternary ammonium salt as well as preparation method and application thereof

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Effect test

Embodiment 1

[0022] A kind of preparation method of tannic acid pyridine class quaternary ammonium salt, comprises the following steps:

[0023] (1) Prepare tannic acid aqueous solution (0.05mol / L) and 4-dimethylaminopyridine (DMAP) aqueous solution (0.2mol / L);

[0024] (2) Take 10mL of tannic acid aqueous solution in a container, slowly add 10mL of 4-dimethylaminopyridine aqueous solution dropwise under stirring conditions, the solution changes from yellow transparent to yellow-green particles in suspension, and after the reaction is completed, perform suction filtration to obtain The filter residue was washed three times with pure water, and treated in a vacuum oven at room temperature of 0.085Mpa for 12 hours. The product turned dark green. After taking it out, it was ground into powder and stored in a desiccator.

Embodiment 2

[0026] A kind of preparation method of tannic acid pyridine class quaternary ammonium salt, comprises the following steps:

[0027] (1) Prepare tannic acid aqueous solution (0.05mol / L) and 4-aminopyridine (4-NH 2 Py) aqueous solution (0.2mol / L);

[0028] (2) Take 10mL of tannic acid aqueous solution in a container, slowly add 10mL of 4-aminopyridine aqueous solution dropwise under stirring conditions, the solution changes from yellow transparent to white particles in suspension, after the reaction is completed, carry out suction filtration to obtain the filter residue, use Wash it with pure water three times, and treat it in a vacuum drying oven at 0.085Mpa for 12 hours at room temperature. The product is off-white. Take it out and grind it into powder, and store it in a desiccator.

Embodiment 3

[0030] A kind of preparation method of tannic acid pyridine class quaternary ammonium salt, comprises the following steps:

[0031] (1) Prepare tannic acid aqueous solution (0.05mol / L) and 2-aminopyridine (2-NH 2 Py) aqueous solution (0.2mol / L);

[0032] (2) Take 10mL of tannic acid aqueous solution in a container, and slowly add 10mL of 2-aminopyridine aqueous solution dropwise under stirring conditions, the solution changes from yellow transparent to white particles suspended, after the reaction is completed, carry out suction filtration to obtain the filter residue, use Wash it with pure water three times, and treat it in a vacuum drying oven at 0.085Mpa for 12 hours at room temperature. The product changes from white to dark green. Take it out and grind it into powder, and store it in a desiccator.

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Abstract

The invention belongs to the field of natural organic acid pyridine quaternary ammonium salt antibacterial materials, and particularly relates to a tannic acid pyridine quaternary ammonium salt preparation method, which comprises: (1) respectively preparing a tannic acid solution and a pyridine compound solution; and (2) putting a certain amount of tannic acid solution into a container, slowly adding the pyridine compound solution under a stirring condition, and carrying out suction filtration, washing and drying after the reaction is finished, thereby obtaining the product. The antibacterialeffect of the obtained product is obviously improved, the product has good stability and compatibility, meanwhile, the unpleasant odor of pyridine substances is also reduced, and the product is more convenient to apply.

Description

technical field [0001] The invention relates to a preparation method of tannic acid pyridine quaternary ammonium salt with antibacterial activity, belonging to the field of natural organic acid pyridine quaternary ammonium salt antibacterial materials. Background technique [0002] Quaternary ammonium salts are a class of antibacterial agents that have been widely studied and widely used, and have been developed to the fifth generation. N in its cation + It can be adsorbed on the cell wall of negatively charged bacteria through electrostatic interaction, destroying the normal operation of the cell wall function, and causing the protein and ions in the cell to flow out; as a polyphenolic compound derived from natural plants, tannic acid (TA) has antioxidant, Capturing free radicals, antibacterial properties. Tannic acid can affect the synthesis of cell membranes, glycolysis, lipid metabolism, amino acid metabolism, modification at the transcriptional level, redox chains in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H13/08C07H1/00C07D213/74C07D213/73C07D213/20C07D213/127A01N43/90A01N43/40A01P1/00
CPCC07H13/08C07H1/00C07D213/74C07D213/73C07D213/20C07D213/127A01N43/90A01N43/40Y02A50/30
Inventor 倪春林徐奕琳刘维邓双飘刘珊珊高珊珊陈锶寒
Owner SOUTH CHINA AGRI UNIV
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