Preparation method of multi-stimulus synergistic response drug-release bone cement

A synergistic response, bone cement technology, used in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve the problem that the release bone cement cannot be accelerated and sustained drug release, etc., to prevent bone tumor recurrence, high drug loading, good The effect of the application foreground

Active Publication Date: 2021-03-26
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a multi-stimuli synergistic response drug-releasing bone cement, which solves the problem that the existing drug-releasing bone cement cannot independently accelerate and sustain drug release in the initial stage of bone tumor recurrence

Method used

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  • Preparation method of multi-stimulus synergistic response drug-release bone cement
  • Preparation method of multi-stimulus synergistic response drug-release bone cement
  • Preparation method of multi-stimulus synergistic response drug-release bone cement

Examples

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Effect test

Embodiment 1

[0059] A preparation method of a multi-stimuli synergistic response drug-releasing bone cement of the present invention, specifically:

[0060]Step 1, mix MMA, DVB, drug and AIBN with a mass ratio of 1:0.1:0.11:0.01 evenly to obtain a polymerized monomer mixture; then add iron salt solution and heat to 50°C and stir to obtain a drug-loaded magnetic porous polymer The iron ions in the iron salt solution include ferric ions and ferrous ions, the molar ratio of ferric ions to ferrous ions is 10:5, and the volume ratio of MMA to ferric salt solution is 1:3 , the molar concentration of iron ions in the iron salt solution is 0.01mol / L; the drug is doxorubicin; the drug loading rate is 25%; the stirring time is 1h; the average particle size of the drug-loaded magnetic porous polymer particles is 1 μm;

[0061] Step 2, add the drug-loaded magnetic porous polymer particles into the mixed solution A, the solid-to-liquid ratio is 1:3g / ml; add the drug solution and stir for 6h, and precip...

Embodiment 2

[0072] A preparation method of a multi-stimuli synergistic response drug-releasing bone cement of the present invention, specifically:

[0073] Step 1, mix MMA, DVB, drug and AIBN with a mass ratio of 2:0.825:0.283:0.045 evenly, add iron salt solution and heat to 55°C and stir to obtain drug-loaded magnetic porous polymer particles; iron in iron salt solution The ions include ferric ions and ferrous ions, the molar ratio of ferric ions to ferrous ions is 1:0.625, the volume ratio of MMA to iron salt solution is 1:3.25, the molar concentration of iron ions in the iron salt solution is 0.133mol / L; the drug is DOX; the drug loading rate is 32.5%; the stirring time is 2h; the average particle size of the drug-loaded magnetic porous polymer particles is 2 μm;

[0074] Step 2, add the drug-loaded magnetic porous polymer particles to the mixed solution A, the solid-to-liquid ratio is 1:3.5g / ml; then add the drug solution and stir for 10.5h to precipitate CTAB and SiO 2 and n-hexane ...

Embodiment 3

[0085] A preparation method of a multi-stimuli synergistic response drug-releasing bone cement of the present invention, specifically:

[0086]Step 1, mix MMA, DVB, drug and AIBN with a mass ratio of 3:1.55:0.455:0.08 evenly, add iron salt solution and heat to 60°C and stir to obtain drug-loaded magnetic porous polymer particles; Iron ions include ferric ions and ferrous ions, the molar ratio of ferric ions to ferrous ions is 1:0.75, the volume ratio of MMA to iron salt solution is 1:3.5, and the molar ratio of iron ions in iron salt solution The concentration is 0.255mol / L; the drug is MTX; the drug loading rate is 40%; the stirring time is 3h; the average particle size of the drug-loaded magnetic porous polymer particles is 3 μm;

[0087] Step 2: Add the drug-loaded magnetic porous polymer particles into the mixed solution A, then add the drug solution and stir for 6-24 hours to precipitate CTAB and SiO 2 and n-hexane shell layer; after collecting microspheres, reflux in ac...

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Abstract

The invention discloses a preparation method of multi-stimulus synergistic response drug-release bone cement. The method comprises the following steps of firstly, preparing a drug-loading SiO2 layer coated drug-loading magnetic porous polymer microsphere, forming a polyelectrolyte shell layer on the surface of the microsphere, and etching an SiO2 layer to form a drug-loading magnetic response microcapsule; and then coating the surface of the microcapsule with a drug-loading P(NIPAM-AM) / MMT temperature-sensitive layer, coating the surface of the temperature-sensitive layer with a chitosan hydrogel layer, finally uniformly mixing a pH-temperature-magnetic field synergistic response microcapsule, a P(MMA-HEMA) water-swelling microsphere and PMMA bone cement powder with a liquid phase, performing stirring, and performing injection. The bone cement can autonomously and slowly release drugs at the early stage of tumor recurrence; when the tumor is aggravated, the drug release amount can be controlled by applying a magnetic field, and meanwhile, thermal therapy can be performed on the tumor part by combining the magnetic field with the temperature-sensitive layer; and when the magnetic field stops, the drug release is slow, the local pH value returns to normal, and the drugs are no longer released.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to a preparation method of multi-stimuli synergistic response drug-releasing bone cement. Background technique [0002] Bone tumor is one of the common bone tissue diseases. Surgical resection is a common treatment for bone tumors. However, surgical resection cannot guarantee the complete removal of bone tumor cells, which may easily cause bone tumor recurrence and cause large bone defects. The cycle of bone tumor recurrence is longer, and changes in the local microenvironment (pH=6.5-6.8) appear first, followed by the production of bone tumor markers. At present, the bone and joint replacement (bone cement commonly used in clinic) used in the treatment of tumor recurrence is performed after the appearance of bone tumor markers, and it cannot be directly and continuously released drug therapy in the early stage of bone tumor recurrence, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/02A61L27/16A61L27/50A61L27/54C08F220/14C08F212/36C08F265/10C08F220/56C08F220/20C08F120/14
CPCA61L27/20A61L27/025A61L27/16A61L27/50A61L27/54C08F220/14C08F265/10C08F120/14A61L2300/602A61L2300/416A61L2430/02A61L2400/06C08L5/08C08L39/06C08L33/24C08L33/12C08F212/36C08F220/56C08F220/20
Inventor 汤玉斐魏敏吴子祥赵康张博梁倩
Owner XIAN UNIV OF TECH
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