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Zinc sulfate and lysine oral liquid and preparation method thereof

A technology of lysine hydrochloride and zinc sulfate, which is applied in blood diseases, pharmaceutical formulations, dispersion liquid delivery, etc., can solve the problems of lack of zinc and lysine oral preparations, etc., and achieve simple preparation process, strong stability, and good taste Effect

Pending Publication Date: 2021-03-30
THE CHILDRENS HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to drug information, there are only Zinc Glucose Tablets and Zinc Lysine Granules on the market for the combination of zinc and lysine, and there is still a lack of oral preparations for the combination of zinc and lysine

Method used

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  • Zinc sulfate and lysine oral liquid and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Prescription:

[0020]

[0021] 2. Process steps:

[0022] (1) Dissolve zinc sulfate and citric acid in an appropriate amount of purified water, and filter;

[0023] (2) Dissolve lysine hydrochloride in an appropriate amount of warm purified water, and filter;

[0024] (3) After adding the simple syrup, slowly add the pineapple essence, and stir as you add;

[0025] (4) Then slowly add the ethylparaben solution dissolved in a little ethanol in advance, and stir with adding;

[0026] (5) Add purified water to the full amount and stir well;

[0027] (6) Fill and seal with a 10ml glass bottle;

[0028] (7) Sterilize the filled and sealed sample by circulating steam at 100°C for 30 minutes;

[0029] (8) Light inspection and packaging of the sterilized sample.

Embodiment 2

[0030] Embodiment 2 oral liquid carries out stability evaluation

[0031] The samples were placed in a shading and airtight environment at room temperature, and the properties of the solution, the contents of zinc sulfate and lysine, and the microbial limit were investigated at 0 months, 3 months, 6 months, 9 months, and 12 months.

[0032] The inspection results are shown in Table 1 below.

[0033] placement time character content Microbial Limit 0 month Colorless to light yellow clear liquid Compliance Compliance March Colorless to light yellow clear liquid Compliance Compliance June Colorless to light yellow clear liquid Compliance Compliance September Colorless to light yellow clear liquid Compliance Compliance December Colorless to light yellow clear liquid Compliance Compliance

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Abstract

The invention provides a zinc sulfate and lysine oral liquid and a preparation method thereof. The oral liquid is prepared from zinc sulfate, lysine, citric acid, simple syrup, pineapple essence, ethylparaben and purified water. The oral liquid is designed for children, has good taste, strong stability and high bioavailability of zinc and lysine, and can be used for scientifically and reasonably supplementing trace elements zinc and lysine required by children. Meanwhile, the zinc sulfate and lysine oral liquid can be used for regulating metabolic balance in children and promoting growth and development, is used for treating growth and development retardation, inappetence, anemia, malnutrition and the like caused by zinc and lysine deficiency of children, and is good in taste, strong in stability and simple in preparation process.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a pharmaceutical preparation composition, in particular to a zinc sulfate and lysine oral liquid and a preparation method thereof. Background technique [0002] Zinc is one of the essential trace elements for the human body and plays an extremely important role in the growth and development of the human body. Zinc participates in the synthesis of various enzymes such as human DNA polymerase and alkaline phosphatase, which can accelerate growth and development, promote wound repair, participate in the regulation of sensory functions, participate in energy metabolism, and regulate immune functions. Zinc deficiency can lead to decreased immunity, growth retardation, mental retardation, loss of appetite, vision problems, skin damage, and hypoplasia of sexual organs in children. [0003] Lysine is one of the essential amino acids for the human body and cannot be synthesized by itself. Lack of l...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K9/08A61K47/26A61P1/14A61P3/02A61P7/06A61P43/00A61K31/198
CPCA61K33/30A61K31/198A61K9/0095A61K47/26A61P3/02A61P1/14A61P7/06A61P43/00A61K2300/00
Inventor 舒强
Owner THE CHILDRENS HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE
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