Aluminum hydroxide adjuvant as well as preparation method and application thereof
A technology of aluminum hydroxide and adjuvant, applied in alumina/aluminum hydroxide, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as general protein adsorption capacity, and achieve stable physical and chemical properties and uniform particle size. , the effect of small inflammatory response
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Embodiment 1
[0055] Add 1 liter of a mixture containing 0.5M aluminum chloride and 2M sodium acetate into a 3 liter reaction tank, raise the temperature to 60°C, and start the paddle stirring at a speed of 500 revolutions per minute, then A mixture of 1.5M sodium hydroxide solution and 2M sodium acetate was added dropwise at a rate of 50 ml per minute, and the pH of the system was monitored. When the pH of the system rose to 7.0, stirring was continued for 1 hour. A 300 ml sample was then taken (sample 4). The remaining product was autoclaved (121 degrees, 30 minutes) (sample 5).
[0056] The samples before and after sterilization were changed by centrifugation, and then the crystal form was analyzed by X-ray diffraction, and the results were as follows: Figure 4-5 shown. The sample before sterilization (sample 4) is neither shapeless nor crystalline, and is an intermediate crystal structure in which amorphous aluminum hydroxide transitions to crystal, that is, the literature (Hydrother...
Embodiment 21
[0071] Add 1 liter of a mixture containing 0.5M aluminum chloride and 2M sodium acetate into a 3 liter reaction tank, raise the temperature to 50°C, and start the paddle stirring at a speed of 500 revolutions per minute, then A mixture of 1.5M sodium hydroxide solution and 2M sodium acetate was added dropwise at a rate of 50 ml per minute, and the pH of the system was monitored. When the pH of the system rose to 7.0, stirring was continued for 1 hour. A 300 ml sample was then taken (sample 6A). The remaining product was autoclaved (121 degrees, 30 minutes) (sample 6B).
Embodiment 22
[0073] Add 1 liter of a mixture containing 0.5M aluminum chloride and 2M sodium acetate into a 3 liter reaction tank, raise the temperature to 70°C, and start the paddle stirring at a speed of 500 revolutions per minute, then A mixture of 1.5M sodium hydroxide solution and 2M sodium acetate was added dropwise at a rate of 50 ml per minute, and the pH of the system was monitored. When the pH of the system rose to 7.0, stirring was continued for 1 hour. A 300 ml sample was then taken (sample 7A). The remaining product was autoclaved (121 degrees, 30 minutes) (sterilization means commonly used in the art) (sample 7B).
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