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Equipment for preparing polyvinyl alcohol embolic microspheres with uniform particle size and its production process

A polyvinyl alcohol embolism microsphere, uniform technology, applied in the field of medical polymer materials, can solve the problems of large particle size uniformity error, difficult process amplification, low efficiency, etc., to improve product stability and high degree of crosslinking , the effect of fast response time

Active Publication Date: 2021-09-28
SUZHOU HENGRUI HONGYUAN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above-mentioned microfluidic technology solutions are still mainly in the stage of scientific research. Using a single pipeline or a single chip to prepare microspheres with uniform particle size is difficult to scale up the process. At present, there is still no microfluidic production process to prepare a large number of microspheres, which lacks stable, Directly related equipment for high-efficiency and high-throughput preparation of microspheres. At the same time, there are no clear adaptability to the materials for preparing microspheres, repeatability of chip processing, large error in particle size uniformity, uncontrollable microsphere formation, and low efficiency. In particular, it is difficult to meet the batch and standardization requirements for the preparation of polyvinyl alcohol embolic microspheres required for medical treatment

Method used

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  • Equipment for preparing polyvinyl alcohol embolic microspheres with uniform particle size and its production process
  • Equipment for preparing polyvinyl alcohol embolic microspheres with uniform particle size and its production process
  • Equipment for preparing polyvinyl alcohol embolic microspheres with uniform particle size and its production process

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Effect test

Embodiment 1

[0080] This embodiment schematically shows the equipment for preparing polyvinyl alcohol embolic microspheres with uniform particle size in the embodiment of the present invention, such as figure 1 As shown, the equipment for preparing polyvinyl alcohol embolism microspheres with uniform particle size includes three major systems: feeding system, microsphere generation module, and curing device, as follows:

[0081] (1) The material feeding system is divided into dispersed phase material feeding and mobile phase material feeding, figure 1 The production process shows that the precision pressure pump is selected as the schematic diagram of the two-phase material drive device, the flow rate of the dispersed phase is controlled at 0.1-500 μL / min, and the flow rate of the mobile phase is 100-50000 μL / min. The dispersed phase material is used to transport the material to the microsphere generation module in a stable, continuous, and high-throughput manner. At the same time, high-p...

Embodiment 2

[0089] Example 2 Preparation method of polyvinyl alcohol embolic microspheres with uniform particle size

[0090] In this embodiment, a precision pressure pump is used to transport materials, and the microsphere generating device is a focusing chip, the inner diameter of the dispersed phase pipeline is 20±10 μm, and the inner diameter of the mobile phase pipeline is 20±10 μm. Such as figure 1 As shown, the specific steps are as follows:

[0091] (1) Preparation of dispersed phase materials: Weigh 0.4g of potassium persulfate and add 100g of water, magnetically stir to dissolve, slowly add 10g of sodium acrylate dropwise, stir evenly, then add 10g of polyvinyl alcohol derivatives, stir evenly, as the dispersed phase material spare.

[0092] (2) Preparation of mobile phase materials: Add 10 g of fatty acid sorbitan surfactant into 1000 mL of ethyl acetate solution, then add 10 mL of triethanolamine, stir well, and use as mobile phase materials for later use.

[0093] (3) Devi...

Embodiment 3

[0096] Example 3 Preparation method of polyvinyl alcohol embolic microspheres with uniform particle size

[0097] In this embodiment, a precision pressure pump is used to transport materials, and the microsphere generating device is a focusing chip. The inner diameter of the dispersed phase pipeline is 60±10 μm, and the inner diameter of the mobile phase pipeline is 90±50 μm. Such as figure 1 As shown, the specific steps are as follows:

[0098] (1) Preparation of dispersed phase materials: Weigh 0.4g of potassium persulfate and add 100g of water, magnetically stir to dissolve, slowly add 10g of sodium acrylate dropwise, stir evenly, then add 10g of polyvinyl alcohol derivatives, stir evenly, as the dispersed phase material spare.

[0099] (2) Preparation of mobile phase materials: Add 10 g of fatty acid sorbitan surfactant into 1000 mL of butyl acetate solution, then add 10 mL of triethanolamine, stir evenly, and use as mobile phase materials for later use.

[0100] (3) De...

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Abstract

The invention relates to equipment for preparing polyvinyl alcohol embolic microspheres with uniform particle size and a production process thereof, belonging to the technical field of medical polymer materials. It provides equipment through the combination of the three systems of feeding system, microsphere generation module and curing device. In the feeding system, the water phase material is fed through the dispersed phase feeding system, and the oil phase material is fed through the mobile phase feeding system; through the control The device controls the material to flow into the microreactor of the corresponding diameter. In the microreactor pipeline, the water phase material is sheared into small droplets under the shear force of the oil phase material to form a water-in-oil structure, and finally solidified The device is used to prepare polyvinyl alcohol embolic microspheres with uniform particle size. The invention realizes automatic, standardized and controllable production, significantly improves the production efficiency of polyvinyl alcohol embolization microspheres, and at the same time achieves the purpose of precisely controlling the size of polyvinyl alcohol embolization microspheres, and realizes uniform particle size of the product. , medical devices and other fields are of great significance.

Description

technical field [0001] The invention relates to equipment for preparing polyvinyl alcohol embolic microspheres with uniform particle size and a production process thereof, belonging to the technical field of medical polymer materials. Background technique [0002] Neoplastic cancer has become the primary problem that endangers global public health. In my country, there are about 4 million new cancer patients every year, and 600,000 to 700,000 people undergo tumor interventional therapy, which is increasing at a rate of 10-20%. With the development of minimally invasive technology, drug-eluting embolization microsphere chemoembolization is emerging as a new embolization technology, which can not only load chemotherapy drugs, but also play an embolization role, so as to achieve continuous treatment of tumors and improve treatment effects. [0003] The use of polyvinyl alcohol embolization microspheres in the treatment of tumor diseases is already a very important clinical trea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02C08F261/04C08F220/06C08F220/58
CPCB01J13/02C08F261/04C08F220/06
Inventor 颜志平马亚丹张宁
Owner SUZHOU HENGRUI HONGYUAN MEDICAL TECH CO LTD