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A kind of silk fiber-reinforced base meniscus composite scaffold with multi-layer bionic structure and preparation method thereof

A technology of silk fibers and composite scaffolds, applied in the direction of layered products, tissue regeneration, prostheses, etc., can solve the problems of unsuitable mechanical performance requirements of meniscal scaffolds, achieve excellent biocompatibility, improve mechanical properties, and increase porosity The effect of rate and aperture size

Active Publication Date: 2022-03-29
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as a SF / WK composite porous material with excellent biocompatibility, but without fiber reinforcement, it is not suitable for the mechanical performance requirements of the meniscal scaffold

Method used

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  • A kind of silk fiber-reinforced base meniscus composite scaffold with multi-layer bionic structure and preparation method thereof
  • A kind of silk fiber-reinforced base meniscus composite scaffold with multi-layer bionic structure and preparation method thereof
  • A kind of silk fiber-reinforced base meniscus composite scaffold with multi-layer bionic structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This implementation case shows a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure. see figure 1 , figure 1 It is a structural schematic diagram of a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure according to the present invention. Such as figure 1 As shown, firstly, the raw material of the outer layer 2 is a non-oriented regenerated SF electrospun fiber membrane; the middle layer 3 is a silk short fiber reinforced base SF / WK porous bionic matrix, and the middle layer 3 is provided with radially arranged reinforcing fibers 4; Layer 5 is an oriented regenerated SF electrospun fiber membrane. The preparation sequence is the outer layer 2 (SF electrospinning), then the inner layer 5 (SF electrospinning), and finally stacked together in the order of outer layer 2-intermediate layer 3-inner layer 4 and freeze-dried to prepare a complete meniscal scaffold 1. Specifically include the following step...

Embodiment 2

[0044] Such as figure 1 As shown, this implementation case shows a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure. The meniscus support described in this embodiment is a silk fiber reinforced base meniscus composite support with a multi-layer bionic structure. First, the raw material of the outer layer 2 is non-oriented PLA melted electrospun fiber membrane; the middle layer 3 is a SF / collagen composite porous biomimetic matrix, and the middle layer 3 is provided with radially arranged reinforcing fibers 4; the inner layer 5 is oriented regenerated SF Electrospun fiber membrane. The preparation sequence is the outer layer 2 (PLA electrospinning), then the inner layer 5 (SF electrospinning), and finally in the order of outer layer 2-intermediate layer 3-inner layer 5 by stacking together at -40 to -80 degrees Celsius, 36 The complete meniscal scaffold was prepared by freeze-drying under the condition of ~60h. Specifically include the fo...

Embodiment 3

[0050] Such as figure 1 As shown, this implementation case shows a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure. The meniscus bracket manufactured in this embodiment is a composite bracket of silk fiber reinforced meniscus with a multi-layer bionic structure. First, the raw material of the outer layer 2 is a non-oriented SF / PCL electrospun fiber film; the middle layer 3 is a silk short fiber reinforced base SF / WK porous bionic matrix, and the middle layer 3 is provided with reinforcing fibers 4 arranged radially; the inner layer 5 It is an oriented pure SF aqueous solution electrospun fiber membrane. The preparation sequence is the outer layer 2 (SF / PCL electrospinning), then the inner layer 5 (SF electrospinning), and finally in the order of outer layer 2-intermediate layer 3-inner layer 5 by layering together at -40 to -80 degrees Celsius , freeze-dried under the condition of 36-60h to prepare the complete meniscal scaffold. Specif...

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Abstract

The invention discloses a silk fiber reinforced base meniscus composite stent with a multi-layer bionic structure and a preparation method thereof, comprising: an outer layer, a middle layer and an inner layer; Lactic acid melt electrospinning fiber membrane or any one of silk fibroin / polycaprolactone electrospinning fiber membrane, the middle layer is silk short fiber reinforced base silk fibroin / wool protein porous biomimetic matrix or silk fibroin / collagen composite Porous biomimetic matrix, with reinforcing fibers arranged radially in the middle layer, the inner layer is an oriented silk fibroin fibrous membrane or an oriented pure silk fibroin aqueous solution electrospun fibrous membrane, and the outer layer, the middle layer and the inner layer are stacked in sequence After compounding, freeze-drying is performed to obtain a meniscus scaffold, which has excellent mechanical properties, biocompatibility and ability to induce tissue regeneration.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a silk fiber-reinforced meniscus composite bracket with a multi-layer bionic structure and a preparation method thereof. Background technique [0002] The meniscus is the semilunar cartilage plate between the femoral condyle and the tibial plateau of the knee joint, which belongs to fibrocartilage tissue, including the medial meniscus and the lateral meniscus, surrounded by a relatively small amount of fibrochondrocytes and abundant extracellular matrix Formed, its matrix mainly consists of collagen and proteoglycans. Its function is to reduce the pressure on the knee joint, absorb the shock, buffer the force, maintain the coordination of movement, and lubricate the joint. There are many reasons for meniscus damage, but most of them are caused by torsional external force. Due to the unique anatomical structure of the meniscus and the non-healing ability...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B32B9/02A61L27/18A61L27/22A61L27/24A61L27/50A61L27/56D04H1/4326D04H1/435D04H1/541D04H1/728
CPCB32B9/02A61L27/227A61L27/18A61L27/24A61L27/50A61L27/56D04H1/4326D04H1/541D04H1/728D04H1/435A61L2430/06C08L89/00C08L67/04
Inventor 李刚周宇航郑兆柱王晓沁
Owner NANTONG TEXTILE & SILK IND TECH RES INST