Preparation method of high-strength gamma-PGA modified PVA composite hydrogel
A composite hydrogel, -PGA technology, used in medical science, prosthesis, tissue regeneration, etc., can solve problems such as insufficient strength and poor stability, and achieve enhanced mechanical properties, good biocompatibility, and improved mechanical strength. malleable effect
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Embodiment 1
[0018] (1) Preparation of PVA hydrogel: Weigh 1.63 g of PVA powder and add it to 10 mL of deionized water, and use a magnetic stirring water bath to stir at 98 °C for 60 min until the PVA is completely dissolved, and a clear and transparent gel with a mass fraction of 14 wt% is obtained. , Uniform PVA aqueous solution, pour the above aqueous solution into the mold, put it in the refrigerator at -20°C for 24 hours, then put it in the refrigerator at 4°C for 24 hours to form a gel, take the hydrogel out of the mold, and get PVA hydrogel glue.
[0019] (2) γ-PGA modified PVA composite hydrogel: Weigh 10 g γ-PGA and add it to 40 mL deionized water, stir it with a magnetic stirrer at room temperature until it is completely dissolved, and obtain a mass fraction of 20wt% γ-PGA solution, and then place the PVA hydrogel obtained in step (1) in the γ-PGA aqueous solution at room temperature for 24 h, take it out and dry it, and obtain a high-strength γ-PGA modified PVA composite hydroge...
Embodiment 2
[0022] The preparation method and steps of the PVA composite hydrogel in this example are the same as in Example 1, the difference is that the γ-PGA aqueous solution with different mass fractions is used for testing, as shown in Table 1:
[0023] Table 1 Effects of different mass fractions of γ-PGA aqueous solution on the mechanical properties of PVA composite hydrogels
[0024] γ-PGA mass fraction, wt% 0 2.5 5 10 15 20 30 Tensile stress, MPa 0.13 0.21 0.41 3.15 7.9 16.69 6.87 Elongation at break, % 244.29 298.31 353.63 423.25 457.28 511.64 490.09
[0025] It can be seen from Table 1 that the tensile stress of the PVA composite hydrogel prepared by 20wt% γ-PGA aqueous solution is 16.69 MPa, the elongation at break reaches 511.64%, and has high strength mechanical properties; without γ-PGA The tensile stress of the modified PVA hydrogel is only 0.13 MPa, which is not up to the application requirements; with the increase of the amount...
Embodiment 3
[0027] In the present embodiment, the preparation method and steps of PVA composite hydrogel are the same as in Example 1, except that the soaking time of PVA hydrogel placed in 20wt% γ-PGA aqueous solution is changed at room temperature, and the effect of soaking time on PVA is explored. The performance impact of the composite hydrogel is specifically shown in Table 2, Figure 4 Shown:
[0028] Table 2 Effect of soaking time in 20wt% γ-PGA aqueous solution on tensile strength of PVA composite hydrogel
[0029] Soaking time, h 1 3 6 12 24 48 72 Tensile stress, MPa 0.406 2.59 4.08 10.14 16.69 12.392 7.61
[0030] It can be seen from Table 2 that the tensile stress of the obtained PVA composite hydrogel can reach 16.69 MPa after soaking the PVA hydrogel in 20wt% γ-PGA aqueous solution at room temperature for 24 h, which has high-strength mechanical properties; The tensile stress of the PVA composite hydrogel was only 4.08 MPa when the immersion...
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