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Biological ceramic scaffold with micro-nano structure on surface and preparation method and application thereof

A technology of bioceramics and bioactive ceramics, applied in the direction of prosthesis, coating, additive processing, etc., to achieve the effect of promoting osteogenic differentiation, repairing bone defects, and simple preparation methods

Active Publication Date: 2021-04-16
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it remains a great challenge to develop biomaterials with both tumor scavenging ability and bone repair ability

Method used

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  • Biological ceramic scaffold with micro-nano structure on surface and preparation method and application thereof
  • Biological ceramic scaffold with micro-nano structure on surface and preparation method and application thereof
  • Biological ceramic scaffold with micro-nano structure on surface and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 5g of pure feldspar powder was uniformly mixed with 4gF127, and 3D printing technology was used to prepare a feldspar support;

[0040] Calcining the green feldspar stent at 1360°C for 4 hours to obtain a pure feldspar stent;

[0041] Put magnesian feldspar into 0.02mol / L FeSO 4 ·7H 2 Carry out hydrothermal treatment in the aqueous solution of O and L-cysteine, temperature is 180 ℃, time is 12 hours;

[0042] After hydroheating, the scaffold is rinsed with deionized water and absolute ethanol, and dried in an oven at 60° C. to obtain a bioceramic scaffold decorated with ferric sulfide microflowers. Structural characterization of it, the results are as follows figure 1 As shown in the figure, it can be seen from the figure that the pore diameter of the magnesia feldspar scaffold is 100-400 μm; the iron tetrasulfide grows uniformly on the surface of the magnesia feldspar scaffold; The diameter of the micron flowers is 5-50 μm. Then the osteogenic activity and anti-tu...

Embodiment 2

[0056] 5g of pure feldspar powder was uniformly mixed with 4gF127, and 3D printing technology was used to prepare a feldspar support;

[0057] Calcining the green feldspar stent at 1360°C for 4 hours to obtain a pure feldspar stent;

[0058] Put magnesian feldspar into 0.04mol / L FeSO 4 ·7H 2 Carry out hydrothermal treatment in the aqueous solution of O and L-cysteine, temperature is 160 ℃, time is 24 hours;

[0059] After hydroheating, the scaffold was rinsed with deionized water and absolute ethanol, and dried in an oven at 60° C. to obtain a bioceramic scaffold decorated with ferric sulfide microflowers.

Embodiment 3

[0061] 5g of pure feldspar powder was uniformly mixed with 5g of F127, and 3D printing technology was used to prepare a feldspar support;

[0062] Calcining the green feldspar stent at 1300°C for 3 hours to obtain a pure feldspar stent;

[0063] Put magnesian feldspar into 0.02mol / L FeSO 4 ·7H 2 Carry out hydrothermal treatment in the aqueous solution of O and L-cysteine, temperature is 160 ℃, time is 12 hours;

[0064] After hydroheating, the scaffold was rinsed with deionized water and absolute ethanol, and dried in an oven at 60° C. to obtain a bioceramic scaffold decorated with ferric sulfide microflowers.

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Abstract

The invention relates to a biological ceramic scaffold with a micro-nano structure on the surface and a preparation method and application thereof, in particular to a ferroferric sulfide micro-flower modified biological ceramic scaffold, which is characterized by comprising a akermanite scaffold and ferroferric sulfide layer micro-flower particles growing on the surface of the akermanite scaffold, and the diameter of a pore passage of the akermanite scaffold is 100-400 microns; the ferroferric sulfide micro-flower particles are of a micro-nano structure and are assembled by flaky particles with the diameter of 0.5-3 mu m, and the diameter of each flaky particle is 5-50 mu m. The prepared ferroferric sulfide micro-flower modified biological ceramic scaffold can be used for bone tumor postoperative treatment and repair.

Description

technical field [0001] The invention relates to a bioceramic support with a micro-nano structure on the surface and a preparation method and application thereof, in particular to a bioceramic support modified with iron tetrasulfide micro-flowers, a preparation method and an application thereof, belonging to the field of biological materials. Background technique [0002] The treatment of malignant bone tumors has always been a huge clinical problem. At present, there are many methods for the treatment of malignant bone tumors, such as surgical resection, chemotherapy, radiotherapy and so on. Surgical resection will leave a large defect at the resection site, which must be repaired by implants, and surgical resection cannot completely remove tumor cells. Radiotherapy and chemotherapy will cause greater damage to the normal tissues around the tumor, and will also make tumor cells resistant to drugs. Therefore, it remains a great challenge to develop biomaterials with both tu...

Claims

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Application Information

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IPC IPC(8): C04B35/195C04B35/622C01G49/12A61L27/56A61L27/54A61L27/30A61L27/10B33Y10/00B33Y70/10
Inventor 吴成铁庄辉
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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