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Polymer-based multi-element surface-enhanced Raman detection substrate and preparation method and cancer diagnosis application thereof

A surface-enhanced Raman, polymer technology, applied in Raman scattering, vacuum evaporation plating, coating, etc., can solve the problems of inability to distinguish exosome spectra, complex structure preparation, and high cost

Active Publication Date: 2021-04-20
SHANDONG UNIV +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The structure of this technology is complicated to prepare, requires a mask, and the cost is high, and it needs to be enhanced by evaporating a gold film. The sensitivity is average, and it cannot better distinguish the complex spectrum of exosomes.

Method used

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  • Polymer-based multi-element surface-enhanced Raman detection substrate and preparation method and cancer diagnosis application thereof
  • Polymer-based multi-element surface-enhanced Raman detection substrate and preparation method and cancer diagnosis application thereof
  • Polymer-based multi-element surface-enhanced Raman detection substrate and preparation method and cancer diagnosis application thereof

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preparation example Construction

[0040] In a second aspect, the present invention provides a method for preparing the polymer-based multi-component composite surface-enhanced Raman scattering substrate, comprising the following steps:

[0041] Drop resin on the polymer substrate to form a resin layer, transfer the pattern on the mold roll to the resin, and light-cure;

[0042] Evaporate a layer of precious metal film on the pattern structure of the resin layer to make it metallized;

[0043] Evaporate a metal oxide film on the noble metal film;

[0044] Finally, ion sputtering deposits a three-dimensional island-shaped ultra-thin silver film on the surface of the metal oxide film to obtain a polymer-based multi-component composite surface-enhanced Raman scattering substrate.

[0045] In some embodiments, the method of transferring the pattern on the mold roll to the resin is roll-to-roll UV imprinting.

[0046] Further, the embossing speed is 0.1-3m / min, the embossing pressure is 10-50kgf, and the temperatu...

Embodiment 1

[0051] Design and preparation method of a polymer-based multi-component composite surface-enhanced Raman scattering substrate, such as figure 1 and figure 2 As shown, it is composed of a polymer substrate 110 , an ultraviolet curable resin 120 , a noble metal film 130 , a metal oxide film 140 and a three-dimensional island-shaped ultra-thin silver film 150 .

Embodiment 2

[0053] The preparation process of a polymer-based multi-component composite surface-enhanced Raman scattering substrate is as follows: image 3 As shown, the polymer-based multi-component composite surface-enhanced Raman scattering substrate was obtained through roll-to-roll UV imprinting technology, evaporation technology, ion sputtering deposition technology and other process steps. Specifically, the following steps are adopted: on the surface of the polymer substrate 110 (PET film), the UV-curable resin 120 is prepared into a uniform nanostructure array by using roll-to-roll UV imprinting technology, and a layer of noble metal film 130 is deposited on the surface of the resin by evaporation. (silver), then vapor-deposit one layer of metal oxide film 140 (zinc oxide) on the surface of the noble metal film, and finally deposit a three-dimensional island-shaped ultra-thin silver film on the surface of the metal oxide film by ion sputtering to obtain a polymer Multi-element compo...

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Abstract

The invention discloses a polymer-based multi-element surface-enhanced Raman detection substrate and a preparation method and cancer diagnosis application thereof. The polymer-based multi-element surface-enhanced Raman detection substrate sequentially comprises a polymer base material, a resin layer, a noble metal film layer, a metal oxide film layer and a three-dimensional island-shaped ultrathin silver film which are arranged in a mutual overlapping manner; the island-shaped structure in the three-dimensional island-shaped ultrathin silver film is a uniformly distributed nano structure, and the thickness of the silver film is 1.5 to 20 nm. The flexible surface-enhanced Raman scattering substrate has the advantages of simplicity, convenience, high sensitivity, good consistency and high throughput, and can be used for realizing early diagnosis of cancers.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a polymer-based multi-component surface-enhanced Raman detection substrate, a preparation method thereof and a cancer diagnosis application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] As a malignant disease, cancer seriously threatens human life and health. In recent years, the number of people suffering from cancer and the number of cancer deaths have increased year by year. If cancer is detected in the early stage, the survival rate of human beings can be greatly improved through effective treatment. However, since cancer has no obvious symptom...

Claims

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Application Information

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IPC IPC(8): G01N21/65C23C14/02C23C14/24C23C14/20C23C14/08C23C14/34
CPCG01N21/65C23C14/08C23C14/20C23C14/02C23C14/24C23C14/34Y02P70/50
Inventor 杜鲁涛张成鹏陈帅王心凝李娟杨少华季金王传新
Owner SHANDONG UNIV
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