Phloroglucinol injection solution and preparation method thereof

A technology of phloroglucinol injection and phloroglucinol, which is applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor stability and crystallization, and achieve stable High stability, good stability, and the effect of avoiding content loss

Pending Publication Date: 2021-05-04
WUHAN DOCAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product of the invention has controllable quality and high stability, simple process, definite curative effect, better

Method used

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  • Phloroglucinol injection solution and preparation method thereof
  • Phloroglucinol injection solution and preparation method thereof
  • Phloroglucinol injection solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Raw materials Dose (g) Phloroglucinol 10 Trimethylphloroglucinol 0.01 Sodium chloride 7.0 hydrochloric acid 0.7 sodium hydroxide 0.5 Water for Injection up to 1000ml

[0042] Preparation Process:

[0043] (1) Measure 100ml of water for injection and add it to the airtight liquid mixing container A, pour medical clean nitrogen gas to the liquid level to saturate the water for injection, add sodium hydroxide solution dropwise to adjust the pH to 7.5, mix well, add trimethyl m-benzene Triphenol is stirred and dissolved;

[0044] (2) Add sodium chloride and stir to dissolve in the above-mentioned solution;

[0045] (3) Measure 800ml of water for injection and add it to the airtight dosing container B, add hydrochloric acid solution dropwise and mix well, adjust the pH value of the solution to 3.80, pour medical clean nitrogen gas under the liquid surface to saturate the water for injection, add phloroglucinol Stir to dis...

Embodiment 2

[0051]

[0052]

[0053] Preparation Process:

[0054] (1) Measure 80ml of water for injection and add it to the airtight liquid preparation container A, flush medical clean nitrogen gas to the liquid level to saturate the water for injection, add dropwise sodium hydroxide solution to adjust the pH to 8.0, mix well, add trimethyl m-benzene Triphenol is stirred and dissolved;

[0055] (2) Add sodium chloride and stir to dissolve in the above-mentioned solution;

[0056] (3) Measure 800ml of water for injection and add it to the airtight dosing container B, add hydrochloric acid solution dropwise and mix well, adjust the pH value of the solution to 3.80, pour medical clean nitrogen gas under the liquid surface to saturate the water for injection, add phloroglucinol Stir to dissolve;

[0057] (4) Use fixed-speed pumping devices (peristaltic pumps, etc.) at 20rpm to add the liquids in containers A and B to the dilute container C at a constant rate of 1:10 (protected with m...

Embodiment 3

[0062] Raw materials Dose (g) Phloroglucinol 10 Trimethylphloroglucinol 0.01 Sodium chloride 7.0 hydrochloric acid 0.7 sodium hydroxide 0.5 Water for Injection up to 1000ml

[0063] Preparation Process:

[0064] (1) Measure 70ml of water for injection and add it to the airtight liquid preparation container A, flush medical clean nitrogen gas to the liquid level to saturate the water for injection, add sodium hydroxide solution dropwise to adjust the pH to 7.8, mix well, add trimethyl m-benzene Triphenol is stirred and dissolved;

[0065] (2) Add sodium chloride and stir to dissolve in the above-mentioned solution;

[0066] (3) Measure 840ml of water for injection and add it to the airtight liquid mixing container B, add hydrochloric acid solution dropwise and mix evenly, adjust the pH value of the solution to 3.80, flush medical clean nitrogen to the liquid level to saturate the water for injection, add phloroglucinol Stir ...

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Abstract

The invention belongs to the field of medicine preparations, and particularly relates to a phloroglucinol injection solution and a preparation method thereof. The injection solution is used for acute spasmodic pain caused by digestive system and biliary tract dysfunctions. The phloroglucinol injection solution does not have a choline-resisting function, and does not affect cardiovascular functions while smooth muscle spasms are eliminated. The phloroglucinol injection solution disclosed by the invention has the advantages of good stability and the like, is unlikely to change colors in a long-term placement process, and is unlikely to be separated out.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a phloroglucinol injection and a preparation method thereof. Background technique [0002] Clinically, the pain caused by smooth muscle spasm is very common, such as acute spasmodic pain caused by digestive system and biliary tract dysfunction, acute spasmodic urethra, bladder, renal colic, etc. Atropine and anisodamine are anticholinergic drugs commonly used clinically. Although their antispasmodic and analgesic effects are definite in curative effect, they have many adverse reactions. While relieving spasm, it will inhibit the secretion of the glands, relieve the inhibition of the vagus nerve on the heart, make the heart beat faster, dilate the pupils, increase the intraocular pressure, and excite the respiratory center. In view of the fact that it is easy to cause urinary retention in elderly patients, it is contraindicated in patients with glaucoma, and...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/02A61K47/04A61K31/05A61P21/02
CPCA61K9/08A61K9/0019A61K47/02A61K31/05A61P21/02A61K2300/00
Inventor 陆滢炎孙玉娟韩玉洁张小成熊汝菊吴小涛赵卿霍立茹李战
Owner WUHAN DOCAN PHARMA
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