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Polydopamine-coated drug-loaded molybdenum disulfide nanosheet and preparation and application thereof

A technology of molybdenum disulfide and polydopamine, which is applied in the fields of nanotechnology, nanotechnology, and nanomedicine for materials and surface science, can solve the problem of not finding molybdenum disulfide nanosheets, etc., and achieve good drug response and release, good Water-soluble, easy-to-operate effect

Inactive Publication Date: 2021-05-07
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Searching the literature at home and abroad has not yet found reports on the preparation of polydopamine-coated molybdenum disulfide nanosheets, and the combined treatment of cisplatin and 1-MT loaded on its surface for multimodal imaging in vivo

Method used

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  • Polydopamine-coated drug-loaded molybdenum disulfide nanosheet and preparation and application thereof
  • Polydopamine-coated drug-loaded molybdenum disulfide nanosheet and preparation and application thereof
  • Polydopamine-coated drug-loaded molybdenum disulfide nanosheet and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) 100mg ammonium tetrathiomolybdate ((NH 4 ) 2 MoS 4 ) was dissolved in 20mL ultrapure water, and 0.5mL reducing agent hydrazine hydrate ((N 2 h 4 ).H 2 O), transferred to a high-temperature and high-pressure reactor and reacted at 200 ° C for 8 h, after the reaction, centrifuged, washed and dried to obtain molybdenum disulfide nanosheets (MoS 2 ).

[0053] (2) Dissolve 10 mg of dopamine (DA) in 10 mL of Tris buffer with a pH of 8.5, and add 10 mg of MoS prepared in step (1) 2 After 24 hours of open stirring reaction at room temperature, centrifuged and washed, vacuum-dried to obtain polydopamine-coated molybdenum disulfide nanosheets (PDA@MoS 2 ).

[0054] (3) Add 10 mg of PDA@MoS prepared in step (2) 2 Dissolve in 10mL Tris buffer solution with pH 8.5, and add 20mg polyethylene glycol (NH 2 -PEG), centrifuged and washed at 50°C for 36 h, and dried in vacuum to obtain polyethylene glycol-modified polydopamine-coated molybdenum disulfide nanosheets (PEGylated...

Embodiment 2

[0057] 1-MT-Pt-PDA@MoS obtained in Example 1 2 Dissolve it in ultrapure water, prepare a solution with a concentration of 1 mg / mL, drop it on the surface of a copper grid with a carbon film, and dry it at room temperature to prepare a sample. Adopt JEM-2010F type transmission electron microscope to detect sample under 200kV ( figure 2 ). Transmission electron microscopy showed that the as-prepared 1-MT-Pt-PDA@MoS 2 The particle size of the nanosheets is 148±3.87nm.

Embodiment 3

[0059] The MoS in embodiment 1 2 、PDA@MoS 2 、PEGylated PDA@MoS 2 Dissolve them in ultrapure water respectively, prepare a solution with a concentration of 200 μg / mL, and use ultraviolet-visible spectrophotometry to detect the ultraviolet absorption value in the range of 400nm-800nm. The results of UV-Vis spectrophotometry were as follows: image 3 As shown, MoS 2 、PDA@MoS 2 、PEGylated PDA@MoS 2 Both have strong near-infrared absorption, indicating that the subsequent modification did not affect the MoS 2 The near-infrared absorption properties of PEGylatedPDA@MoS 2 It has good light-to-heat conversion performance.

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Abstract

The invention relates to a polydopamine-coated drug-loaded molybdenum disulfide nanosheet and preparation and application thereof. The method comprises the following steps: preparation of a molybdenum disulfide nanosheet, preparation of a molybdenum disulfide nanosheet with a polydopamine coating, preparation of a polyethylene glycol modified molybdenum disulfide nanosheet with the polydopamine coating, and preparation of the polydopamine-coated drug-loaded molybdenum disulfide nanosheet. The method is simple, has mild experimental condition, and is easy to operate, and the prepared polydopamine-coated drug-loaded molybdenum disulfide nanosheet not only can realize photoacoustic / CT bimodal imaging, but also can be used for photothermal therapy, chemotherapy and immune combined therapy of tumors, and has potential application value in the field of tumor diagnosis and treatment.

Description

technical field [0001] The invention belongs to the field of nanomedicine diagnosis and treatment reagents and their preparation and application, in particular to a polydopamine-wrapped drug-loaded molybdenum disulfide nanosheet and its preparation method and application. Background technique [0002] Malignant tumors have the characteristics of fast growth, strong metastasizing ability, and high recurrence rate, and have become the main killer currently threatening human health. Chemotherapy and radiotherapy, traditionally used clinical cancer treatment methods, usually cause damage to normal tissues, and the treatment efficiency is low, and tolerance is prone to occur. Photothermal therapy (PTT) is favored because of its efficient local tumor treatment effect, invasiveness and less side effects. Molybdenum disulfide (MoS 2 ), as a new type of transition metal dichalcogenide inorganic material, has a very high specific surface area and strong surface adsorption properties...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K33/243A61K31/405A61K47/34A61K47/10A61P35/00A61K49/00A61K49/22A61K49/04B82Y5/00B82Y30/00B82Y40/00
CPCA61K31/405A61K41/0052A61K47/10A61K47/34A61K49/0002A61K49/04A61K49/222A61P35/00A61K33/243B82Y5/00B82Y30/00B82Y40/00A61K2300/00
Inventor 沈明武胡伟肖婷婷史向阳邢玲溪
Owner DONGHUA UNIV
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