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A Venus core/hollow silicon shell drug-loaded nano-platform and its preparation and application

A hollow, Venus technology, applied in the field of nanomaterials, can solve the problems of the preparation and application of nanoparticles that have not been found, and achieve the effect of high-efficiency combined treatment and broad application prospects.

Active Publication Date: 2021-06-29
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Searching domestic and foreign literatures and patents on nano-platforms for combined therapy shows that there is no report on the preparation and application of nanoparticles based on DOX-loaded Venus core / hollow silicon shell for combined therapy.

Method used

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  • A Venus core/hollow silicon shell drug-loaded nano-platform and its preparation and application
  • A Venus core/hollow silicon shell drug-loaded nano-platform and its preparation and application
  • A Venus core/hollow silicon shell drug-loaded nano-platform and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Mix absolute ethanol (71.4mL), ultrapure water (10mL) and ammonia water (3.14mL) at room temperature, and stir in a 35°C water bath for 30min, then add 6mL of TEOS, and continue stirring for 1.5h to obtain Solid silica particles sSiO 2 ; then add premixed 5mL TEOS and 2mL C 18 The mixture of TMS was stirred continuously for 1.5h, and collected by centrifugation at 3000r / min to obtain solid silicon particles sSiO wrapped in mesoporous silicon. 2 @mSiO 2 .

[0057] (2) the sSiO obtained in step (1) 2 @mSiO 2 Evenly divided into 6 parts, each product was ultrasonically dispersed in Na 2 CO 3 (0.6M, 50mL) aqueous solution, after ultrasonic dispersion for 10 minutes, the solution was transferred to a constant temperature water bath at 80°C for etching for 5 hours. After the etching, the solution was cooled to room temperature, and the product was collected by centrifugation at 3000r / min, washed with a large amount of absolute ethanol and deionized water to remove ...

Embodiment 2

[0063] Using transmission electron microscope (TEM), ultraviolet-visible spectrophotometer (UV-Vis), nitrogen adsorption-desorption isotherm curve, in vitro drug release kinetics, photothermal conversion performance, cell viability analysis (CCK-8 test) and In Vitro Cell Combination Therapy Characterization The Venus core / hollow mesoporous silica shell nano-platform coated with doxorubicin hydrochloride prepared in Example 1 has the function of combination therapy.

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Abstract

The invention relates to a gold star core / hollow silicon shell drug-carrying nano-platform and its preparation and application. It has a core-shell structure with gold nano-star particles as the core, hollow mesoporous silicon dioxide as the shell, and loaded with drug DOX. The preparation method includes: introducing small-sized gold nanoparticles into the cavity of large-diameter hollow mesoporous silicon dioxide by vacuum infusion, growing into gold nano-star particles in situ, and finally loading anticancer drug DOX to prepare. The nano-platform prepared by the present invention has good colloidal stability and excellent biocompatibility, and has a good combined treatment effect of photothermal and chemotherapy, and provides a new method for the development of combined therapeutic agents for tumors. broad.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a DOX-loaded Venus core / hollow silicon shell nanometer platform and its preparation and application. Background technique [0002] Traditional tumor treatment methods include surgical resection and radiotherapy, etc., and surgery and radiotherapy are local treatments, which are only effective for tumors at the treatment site. For potential metastatic lesions (cancer cells have actually metastasized, but due to the limitations of current technical methods It is difficult to effectively treat cancers that have not yet been discovered and detected) and clinically metastasized cancers. Chemotherapy is a means of systemic treatment. No matter what route of administration is adopted (oral, intravenous and body cavity administration, etc.), chemotherapeutic drugs will spread throughout most of the organs and tissues of the whole body along with the blood circulat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K31/704A61K9/51A61K47/04A61P35/00
CPCA61K9/5115A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 沈明武蔡超欧阳智俊史向阳
Owner DONGHUA UNIV
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