Cu2MoS4 nano-enzyme as well as preparation method, nano-drug and application thereof

A nanozyme, a selected technology, applied in the field of nanomaterials, can solve problems such as difficult to cure cancer, achieve efficient chemical kinetic therapy, relieve hypoxia, and inhibit cancer metastasis

Inactive Publication Date: 2020-03-10
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This unique tumor microenvironment can promote tumor proliferation and metastasis, making it difficult for monotherapy to completely cure cancer

Method used

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  • Cu2MoS4 nano-enzyme as well as preparation method, nano-drug and application thereof
  • Cu2MoS4 nano-enzyme as well as preparation method, nano-drug and application thereof
  • Cu2MoS4 nano-enzyme as well as preparation method, nano-drug and application thereof

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preparation example Construction

[0034] The present invention also provides a kind of above-mentioned Cu 2 MoS 4 The preparation method of the nanozyme comprises: mixing cuprous oxide, an organic carbon source, an inorganic molybdenum source and an organic sulfur source in an organic solvent, and calcining at a high temperature to obtain a hollow Cu 2 MoS 4 nanozyme.

[0035] Wherein, the present invention does not have special limitation to the source of all raw materials and can be commercially available or self-made.

[0036] In the present invention, the cuprous oxide is preferably prepared according to the following method: mix the inorganic copper salt and the polymer surfactant in water, adjust the pH value of the mixed solution to strong alkalinity, then add a reducing agent, and after the reaction, obtain Cuprous oxide.

[0037]Mixing an inorganic copper salt and a polymer surfactant in water, the inorganic copper salt is preferably one or more of copper chloride, copper nitrate and copper sulfat...

Embodiment 1

[0053] Preparation of Cu 2 O precursor: 0.171g CuCl 2 ·H 2 O and 3.333 g of polyvinylpyrrolidone were dispersed in 100 mL of deionized water. After stirring for 10 min, 2mol·L -1 , 10mL of sodium hydroxide solution and 0.6mol·L -1 , 10mL of ascorbic acid solution was added to the above solution one after another. After stirring at room temperature for 1 h, the product was centrifuged (10000rpmmin -1 , 5min), washed with deionized water and ethanol three times respectively, and the product was dried overnight at 60°C in a vacuum oven to obtain Cu 2 O precursor.

Embodiment 2

[0055] Preparation of hollow CMS nanozyme: 40mg Cu 2 The O precursor and 120 mg of glucose were sonicated in 20 mL of ethylene glycol. Then, 70mg Na 2 MoO 4 2H 2 O and 120mg of thioacetamide were added to the above solution, and ultrasonicated for 30min (power 250W). The above mixed solution was transferred to a 45mL polytetrafluoroethylene autoclave, calcined at 200°C for 24h, and then cooled to room temperature. Subsequently, the product was centrifuged (10000 rpm, 5 min), and washed three times with deionized water and ethanol respectively.

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Abstract

The invention provides a preparation method of Cu2MoS4 nano-enzyme, and the method comprises the following steps: mixing cuprous oxide, an organic carbon source, an inorganic molybdenum source and anorganic sulfur source in an organic solvent, and carrying out high-temperature calcination to obtain the hollow Cu2MoS4 nano-enzyme. Compared with the prior art, the Cu2MoS4 nano-enzyme prepared by the invention has catalase activity and greatly relieves tumor hypoxia, and meanwhile, the nano-enzyme also has peroxidase activity and can consume glutathione overexpressed in a tumor, so that an antioxidant defense system of the tumor is destroyed, and the chemokinetic treatment efficiency is enhanced; two pairs of redox couples exist, the redox couples can react with hydrogen peroxide to generatehigh-toxicity hydroxyl radicals, a remarkable chemical and dynamic curative effect is achieved, meanwhile, the nano-enzyme has strong absorption in the whole near-infrared area, and photo-thermal therapy can be achieved; and under laser excitation, superoxide anion free radicals can be generated and used for photodynamic therapy.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, in particular to a Cu 2 MoS 4 Nanozyme, its preparation method, nanomedicine and application. Background technique [0002] In recent years, the research on cancer treatment has made great progress. However, the methods that can be applied clinically basically come from traditional treatment methods such as surgery, chemotherapy and radiotherapy, which often cause certain damage to the immune system and normal healthy tissues. Toxic and side effects, so it is extremely necessary to develop an efficient tumor treatment technology. [0003] It has been reported that solid tumors have an immunosuppressive microenvironment, which is associated with their unique tumor microenvironment, characterized by hypoxia, high concentration of hydrogen peroxide, overexpression of glutathione, etc. This unique tumor microenvironment can promote tumor proliferation and metastasis, making it difficult for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G3/02C01G39/00A61K33/34A61K39/395A61K41/00A61P35/00B82Y5/00B82Y40/00
CPCA61K33/34A61K39/395A61K41/0052A61K41/0057A61P35/00B82Y5/00B82Y40/00C01G3/02C01G39/006C01P2004/34A61K2300/00
Inventor 林君常梦宇侯智尧
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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