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Nano-robot with anti-tumor function and preparation method thereof

A nanorobot, anti-tumor technology, applied in the field of nanomaterials, can solve the problems of poor stability of nanorobot preparation process, poor tumor treatment effect, and poor product size uniformity.

Inactive Publication Date: 2021-05-14
美国发现集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the research on nanorobots with anti-tumor function in the field of tumor treatment is still in the experimental stage, and there are problems such as poor stability of the preparation process of nanorobots, poor product size uniformity, poor degradability, and poor tumor treatment effect. Seriously affected its application in the field of tumor therapy

Method used

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  • Nano-robot with anti-tumor function and preparation method thereof
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  • Nano-robot with anti-tumor function and preparation method thereof

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preparation example Construction

[0032] The invention provides a method for preparing a nanorobot with anti-tumor function, comprising the following steps:

[0033] a) mixing magnetic magnesium alloy nanoparticles, antineoplastic drugs, polylactic acid and a volatile organic solvent to obtain a mixed solution;

[0034] b) mixing the mixed solution with water and stirring to evaporate the volatile organic solvent in the mixed system to obtain a suspension;

[0035] c) centrifuging the suspension and discarding the supernatant to obtain a nanorobot with anti-tumor function.

[0036] In the preparation method provided by the present invention, magnetic magnesium alloy nanoparticles are firstly provided. Wherein, the chemical composition of the magnetic magnesium alloy particles preferably includes Nd, Fe, SiO 2 , Mn, Zn and Mg; the content of the Nd in the magnetic magnesium alloy particles is preferably 3 to 5wt%, specifically 3wt%, 3.5wt%, 4wt%, 4.5wt% or 5wt%; the Fe in the magnetic The content in the magn...

Embodiment 1

[0070] 1) Preparation of magnetic magnesium alloy nanoparticles

[0071] 1.1) Cleaning: Wipe the glass substrate substrate with a size of 300mm×400mm×0.5mm with alcohol, then put it into an ultrasonic cleaner, super-wash with deionized water, super-wash with alcohol, and finally dry the substrate in alcohol vapor , When the substrate is taken out from the steam, the substrate can be dried quickly because the condensed steam evaporates from the surface. In this embodiment, the ultrasonic power in each of the above ultrasonic processes is 150W.

[0072] 1.2) Spin-coated gelatin film layer: place the glass substrate in the worktable of the automatic knife scraper spin-coating machine, automatically position it, and automatically scrape a thin layer of gelatin film layer by the centrifugal law. The rotary scraping speed is 1200rpm. The scraping time is 12 seconds, the uniformity is controlled within ±3%, and then placed in a drying oven at 25±1°C to dry and form a film; the worki...

Embodiment 2

[0090] 1) Preparation of magnetic magnesium alloy nanoparticles

[0091] 1.1) Cleaning: Wipe the glass substrate substrate with a size of 300mm×400mm×0.5mm with alcohol, then put it into an ultrasonic cleaner, super-wash with deionized water, super-wash with alcohol, and finally dry the substrate in alcohol vapor , When the substrate is taken out from the steam, the substrate can be dried quickly because the condensed steam evaporates from the surface. In this embodiment, the ultrasonic power in each of the above ultrasonic processes is 150W.

[0092] 1.2) Spin-coated gelatin film layer: place the glass substrate in the worktable of the automatic knife scraper spin-coating machine, automatically position it, and automatically scrape a thin layer of gelatin film layer by the centrifugal law. The rotary scraping speed is 1000rpm. The scraping time is 10 seconds, the uniformity is controlled within ±3%, and then placed in a drying oven at 25±1°C to dry and form a film; the worki...

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Abstract

The invention belongs to the field of nano materials, and particularly relates to a nano robot with an anti-tumor function and a preparation method thereof. The preparation method provided by the invention comprises the following steps: a) mixing magnetic magnesium alloy nanoparticles, an anti-tumor drug, polylactic acid and a volatile organic solvent to obtain a mixed solution; b) mixing the mixed solution with water, and stirring to volatilize the volatile organic solvent in the mixed system to obtain a suspension; and c) performing centrifugal separation on the suspension, and discarding supernate to obtain the nano robot with the anti-tumor function. The preparation method provided by the invention is stable in production process, and the nanorobot prepared by adopting the method has good size uniformity, degradability and drug sustained release effect, and can accurately reach a tumor part under the control of an external magnetic field to realize targeted therapy of tumors.

Description

[0001] This application claims the priority of the Chinese patent application submitted to the China Patent Office on November 14, 2019, with the application number 201911113672.2, and the title of the invention is "a nanorobot with anti-tumor function and its preparation method", the entire content of which is passed References are incorporated in this application. technical field [0002] The invention belongs to the field of nanomaterials, and in particular relates to a nanorobot with anti-tumor function and a preparation method thereof. Background technique [0003] Tumor tissue is actually a complete ecosystem formed by tumor cells and tumor blood vessels, which not only contains tumor cells, but also has abundant tumor blood vessels inside. Modern biomedical research has proved that there are huge differences in the structure of tumor blood vessels and normal blood vessels. Generally speaking, it takes a year for normal blood vessels to grow, which is a three-layer de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/04A61L24/00
CPCA61L24/02A61L24/046A61L24/0015A61L24/0042A61L2300/216A61L2300/416A61L2300/602A61L2400/12C08L67/04
Inventor 不公告发明人
Owner 美国发现集团有限公司
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