Terahertz microstructure circular dichroism sensing system for living cell detection

Abstract

The invention discloses a THz microstructure circular dichroism sensing system for living cells in a liquid environment. A reflection type structure can effectively weaken the absorption loss of water to THz waves, and the purpose of improving the signal-to-noise ratio of the system is achieved; a THz wave plate is added at an incident end, so that an incident wave is changed into circularly polarized light near 0.8 THz frequency, and chiral sensing detection is carried out by generating a THz chiral spectrum with a high Q value; a THz polaroid is added behind a reflection system, complete polarization state information of emergent waves is detected by rotating the polaroid, and a circular dichroism spectrum is obtained; besides, a silicon dielectric grating is used as a sensor, strong local resonance generated by the silicon dielectric grating can enhance the interaction between THz waves and a sample, the dielectric grating microstructure also has the effects of increasing the contact area with a measured object and forming a microfluid channel, so that the optical response of the sample is enhanced, and the sensing sensitivity is improved. Experimental results show that the sensing sensitivity to resonance intensity change and frequency movement can reach the magnitude order of 3.4 dB*mL/10 <6> cells and the magnitude order of 5.2 GHz*mL/10 <6> cells respectively.

Description

technical field [0001] The invention belongs to the field of terahertz science and technology, and in particular relates to a terahertz microstructure circular dichroism sensing system for detecting living cells in a liquid environment and a method for using the same. Background technique [0002] Terahertz (THz) waves usually refer to frequencies between 0.1 and 10THz (1THz=10 12 Hz) range, between microwave and infrared waves, due to its excellent properties such as low photon energy, non-invasive and non-ionization, it has attracted extensive attention. In recent years, with the development of THz sources, detectors and various modulation devices, THz technology has continued to mature, and it has been widely used in the field of biomedical sensing. At present, researchers have studied enzymes, proteins, microorganisms, cells, tissues, etc. Biomass sensing studies were performed. Timely and accurate sensing and detection of cells is of great significance. At present, ph...

AI Technical Summary

Problems solved by technology

[0007] To sum up, on the one hand, the rapid development of THz technology and the urgent needs of biology, chemistry and other fields put forward higher performance requirements for THz sensing and detection systems; on the other hand, the existing traditional THz sensing systems It has defects such as low sensitivity, limited detection information, and poor applicability.

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