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Antifungal flutrimazole shampoo preparation and preparation process thereof

A technology of flutramazole and shampoo, applied in the field of pharmaceutical preparations, can solve the problems of poor solubility and poor stability of raw materials

Active Publication Date: 2021-05-18
武汉久安药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of new medicated shampoo for the defective of prior art, be used for local treatment scalp pityriasis (dandruff), seborrheic dermatitis; Antifungal flutrimazole of the present invention Shampoo preparation, which solves the technical problems of poor solubility and poor stability of raw materials, and has good softness, conditioning and hair cleansing effects

Method used

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  • Antifungal flutrimazole shampoo preparation and preparation process thereof
  • Antifungal flutrimazole shampoo preparation and preparation process thereof
  • Antifungal flutrimazole shampoo preparation and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1 provides a kind of antifungal shampoo preparation with flutrimazole, and its composition is shown in the following table:

[0070]

[0071]

[0072] The preparation technology of this antifungal shampoo preparation with flutrimazole is as follows:

[0073] S1. Preparation of flutrimazole solution: disperse flutrimazole in Tween 20, propylene glycol, glycerin, heat in an oil bath at 100°C until dissolved, and let cool for later use;

[0074]S2. Add water, EDTA2Na, AES, PEG-75 lanolin, and flutrimazole solution to the batching pot sequentially in a water bath at 80°C, stir until dissolved and evenly mixed, and let cool to 50°C;

[0075] S3. Mix water-soluble olive oil, cocamide DEA, essence, PPG-3 octyl ether and set aside;

[0076] S4. Add CAB35, the solution obtained in step S3, acrylic acid (ester) copolymer (SF-1) aqueous solution, 10% sodium hydroxide solution, emulsified silicone oil 7137, and emulsified silicone oil 1785 to the above-mentioned b...

Embodiment 2

[0079] Embodiment 2 provides a kind of antifungal flutrimazole hair shampoo preparation, and its composition is as shown in the following table:

[0080]

[0081] The preparation technology of this antifungal shampoo preparation with flutrimazole is as follows:

[0082] S1. Preparation of flutrimazole solution: disperse flutrimazole in Tween 20 and propylene glycol, heat in an oil bath at 100°C until dissolved, and let cool for later use;

[0083] S2. Add water, EDTA2Na, APG0810, CAB35, and flutrimazole solution to the batching pot in a 50°C water bath, and stir until dissolved;

[0084] S3. Add polydimethylsiloxane propyl PG-betaine, imidazolidinyl urea, Aculyn22 aqueous solution, and sodium hydroxide solution to the above batching pot in sequence, and stir until dissolved and mixed;

[0085] S4. Slowly add sodium chloride to the above-mentioned batching pot to adjust the viscosity, and replenish the water to the full amount; let it cool and defoam to obtain the antifunga...

Embodiment 3

[0087] Embodiment 3 provides a kind of antifungal flutrimazole hair shampoo preparation, and its composition is shown in the following table:

[0088]

[0089] The preparation technology of this antifungal shampoo preparation with flutrimazole is as follows:

[0090] S1. Preparation of flutrimazole solution: disperse flutrimazole in Tween 20, propylene glycol, glycerin, heat in an oil bath at 100°C until dissolved, and let cool for later use;

[0091] S2. Add water, EDTA2Na, AES, APG0810, PEG-75 lanolin, and flutrimazole solution to the batching pot in an 80°C water bath, stir until dissolved and mix well, and let cool to 50°C;

[0092] S3. Mix water-soluble olive oil, cocamide DEA, essence, PPG-3 octyl ether and set aside;

[0093] S4. Add CAB35, the solution obtained in step S3, acrylic acid (ester) copolymer (SF-1) aqueous solution, 10% sodium hydroxide solution, emulsified silicone oil 7137, and emulsified silicone oil 1785 to the above-mentioned batching pot in sequen...

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Abstract

The invention provides an antifungal flutrimazole shampoo preparation and a preparation process thereof. The shampoo preparation is prepared from the following components in parts by weight: 0.1-3.0% of flutrimazole, 10-80% of a surfactant, 1-10% of a solubilizer, 0-8% of a cosolvent, 1-8% of a conditioner, 0.5-4% of a rheological regulator, 0.05-0.1% of a chelating agent, 0.05-1% of a preservative, 0-1% of a pH regulator, 0-0.5% of essence and the balance purified water. The antifungal flutrimazole shampoo preparation can provide new medicinal shampoo for patients, and is used for locally treating pityriasis capitis (dandruff) and seborrheic dermatitis. Meanwhile, the technical problems of poor solubility and poor stability of flutrimazole are solved, and the antifungal flutrimazole shampoo preparation has good softening, conditioning and hair cleaning effects. The invention further provides a preparation process of the antifungal flutrimazole shampoo preparation. The preparation process is simple and feasible, high in controllability and easy for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to medicinal hair shampoos, in particular to an antifungal flutrimazole shampoo preparation and a preparation process thereof. Background technique [0002] Scalp pityriasis (dandruff) and seborrheic dermatitis are common and frequently-occurring diseases in dermatology. They can occur in all ages and are mainly caused by fungal infections. With the widespread application of high-efficiency broad-spectrum antibiotics, adrenal cortex hormones and immunosuppressants in recent years, as well as the gradual increase in human organ tissue transplantation, surgical interventional therapy, and the proliferation of many viruses, fungal infections have become increasingly serious. The incidence of regional infections has increased significantly, and the emergence of some drug-resistant strains has also challenged the treatment of fungal diseases. [0003] According to rese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61P17/00A61P31/10A61P17/08A61K8/49A61Q5/02A61Q5/00A61Q5/12A61Q17/00
CPCA61K31/4174A61P17/00A61P31/10A61P17/08A61K8/4946A61Q5/02A61Q5/006A61Q5/12A61Q17/005A61K2800/782
Inventor 金牮马冬冬陈寅郝超张桂森
Owner 武汉久安药物研究院有限公司