Drug combination composition for type 2 diabetes and liver injury and application of drug combination composition

A type 2 diabetes and combined drug technology, applied in the field of biomedicine, can solve the problems that the gain effect has not been further verified, and there is no detailed report
CN112807438AActive Publication Date: 2021-05-18JIANGSU DAYSEBIOTECH LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU DAYSEBIOTECH LTD
Publication Date
2021-05-18

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Abstract

The invention provides a drug combination composition for type 2 diabetes and liver injury and an application of the drug combination composition, and belongs to the field of biological medicine. The drug combination composition comprises selenium-enriched probiotics and thiazolidinedione medicine pioglitazone, and experiments of a type 2 diabetes mouse model constructed by combining high-fat feeding with STZ injection find that after the selenium-enriched probiotics DD98 and the pioglitazone are combined for administration, the weight and fasting blood glucose of the mouse can be obviously improved, liver lipid deposition, oxidative stress and inflammation levels can be reduced, and liver tissue damage can be relieved, so that the administration dosage of the pioglitazone is reduced, and a basis is provided for clinically avoiding side effects of the pioglitazone.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a combination medicine composition for type 2 diabetes and liver injury and application thereof. Background technique

[0002] Diabetes is a metabolic disease characterized by hyperglycemia. Long-term hyperglycemia can lead to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. Diabetes is one of the most important chronic non-communicable diseases in the world, and is an important global health problem. The global diabetes map released by the International Diabetes Federation in 2017 shows that the number of people with diabetes has reached 425 million, of which type 2 diabetes is diabetes main types of . In recent years, with the development of socio-economic level, changes in population structure and changes in the lifestyle of the whole people, the incidence of diabetes has been increasing year by year. China has becom...

Claims

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