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Cedrol nanoemulsion and optimized preparation method thereof

A cedar alcohol and nanoemulsion technology, which can be used in pharmaceutical formulations, emulsion delivery, active ingredients of hydroxyl compounds, etc., and can solve problems such as limited application

Active Publication Date: 2021-06-01
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its poor water solubility limits its application. Therefore, increasing its water solubility is an effective way to improve the scope of application.

Method used

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  • Cedrol nanoemulsion and optimized preparation method thereof
  • Cedrol nanoemulsion and optimized preparation method thereof
  • Cedrol nanoemulsion and optimized preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. A formula of cedrol nanoemulsion comprises by weight ratio: surfactant: co-surfactant: oil phase solvent: pure water=30:15:5:50.

[0039] Specifically: 30 mg of cedrol, 1.2 g of surfactant, 0.2 g of oil phase solvent, 0.6 g of co-surfactant, and 2.0 g of water.

[0040] Further, the surfactant is castor oil polyoxyethylene ether, the co-surfactant is polyethylene glycol 400, and the oil phase solvent is isopropyl myristate.

[0041] Two, the preparation method of described cedrol nanoemulsion, comprises the following steps:

[0042] a. Precisely weigh 30 mg of cedrol as raw material, add it to 0.2 g of isopropyl myristate, supplement with ultrasound, until cedrol is completely dissolved, and an oil phase is obtained;

[0043] Further, the frequency of the ultrasound is 40kHz, the power is 240w, and the ultrasound time is 2min;

[0044] b. Accurately weigh 1.2g of castor oil polyoxyethylene ether and 0.6g of polyethylene glycol 400, add to the oil phase, mix evenly ...

Embodiment 2

[0048] One, the prescription of a kind of cedrol nanoemulsion comprises by weight ratio: surfactant: co-surfactant: oil phase solvent: pure water=25:17.5:5:52.5, can form transparent and stable nanoemulsion with 30mg cedrol alcohol Milk with a particle size of 18.21 and a polydispersity index (PDI) of 0.121.

[0049] Specifically: 30 mg of cedrol, 1.0 g of surfactant, 0.2 g of oil phase solvent, 0.7 g of co-surfactant, and 2.1 g of water.

[0050] Further, the surfactant is castor oil polyoxyethylene ether, the co-surfactant is polyethylene glycol 400, and the oil phase solvent is isopropyl myristate.

[0051] Two, the preparation method of described cedrol nanoemulsion is:

[0052] a. Accurately weigh 30 mg of cedrol, dissolve it in 0.2 g of isopropyl myristate, supplement with ultrasound, until the cedrol is completely dissolved, and obtain an oil phase;

[0053] Further, the frequency of the ultrasound is 40kHz, the power is 240w, and the ultrasound time is 2min;

[0054...

Embodiment 3

[0056] One, the formula of a kind of cedrol nano-emulsion comprises by weight: surfactant: co-surfactant: oil phase solvent: pure water=22.5: 22.5: 5: 50.0, can form transparent and stable nano-emulsion with 30mg cedrol Milk with a particle size of 18.86 and a polydispersity index (PDI) of 0.131.

[0057] Specifically: 30 mg of cedrol, 0.9 g of surfactant, 0.2 g of oil phase solvent, 0.9 g of co-surfactant, and 2.0 g of water.

[0058] Further, the surfactant is castor oil polyoxyethylene ether, the co-surfactant is polyethylene glycol 400, and the oil phase solvent is isopropyl myristate.

[0059] Two, the preparation method of described cedrol nanoemulsion is:

[0060] a. Accurately weigh 30 mg of cedrol, dissolve it in 0.2 g of isopropyl myristate, supplement with ultrasound, until the cedrol is completely dissolved, and obtain an oil phase;

[0061] Further, the frequency of the ultrasound is 40kHz, the power is 240w, and the ultrasound time is 2min;

[0062] b. Accurat...

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Abstract

The invention belongs to the technical field of preparation of pharmaceutical preparations, and particularly relates to a cedrol nanoemulsion and an optimized preparation method thereof. The nanoemulsion is prepared by adopting a low-energy emulsification method, on the basis of a pseudo-ternary phase diagram screening formula, the particle size and the polydispersity index are taken as evaluation indexes, the nano-emulsion formula is optimized by utilizing SLD, so that an oil phase, a water phase, a surfactant and a cosurfactant are fully fused, the particle size of the obtained nano-emulsion is 16.66 nm, the polydispersity index is 0.087. The cedrol has good centrifugal stability and physicochemical properties, and the solubility of cedrol reaches 7.44 mg.g <-1 >. A foundation is laid for external preparation of cedrol for head skin, promotion of hair growth, treatment of cardiovascular and cerebrovascular system diseases through in-vivo drug delivery of injection preparations, anti-tumor, antibacterial, anti-plasmodium activity and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical preparations, and in particular relates to a cedrol nanoemulsion and an optimized preparation method thereof. Background technique [0002] Nanoemulsion, also known as microemulsion, is a thermodynamically stable system formed by water phase, oil phase, surfactant and co-surfactant in proportion. As an emulsion with an average particle size of 10-100nm, it has high transparency and is often used as Applied in the field of medicine and chemical industry. [0003] Cedrol (Cedrol, CE), also known as cedarol, cedrol, CAS number: 77-53-2, is a high-boiling sesquiterpene alcohol with a weak aroma, with a mild fir aroma, mostly present in cypress In the volatile oils of plants such as Cedaraceae, Pinaceae and Pinaceae. Cedrol has been approved by the U.S. Food and Drug Administration as a flavoring agent or adjuvant, and has been widely used as a flavoring ingredient in cosmetics,...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/045A61K47/44A61K47/14A61K47/10A61P17/14A61P9/00A61P35/00A61P31/04A61P31/10
CPCA61K9/1075A61K9/0014A61K9/0019A61K31/045A61K47/44A61K47/14A61K47/10A61P17/14A61P9/00A61P35/00A61P31/04A61P31/10Y02A50/30
Inventor 杨敏汤陆扬彭黔荣付阳洋王昊杨培昕
Owner GUIZHOU UNIV