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A kind of cerebral protein hydrolyzate compound preparation for neuroprotection and nerve repair and preparation method thereof

A cerebroprotein hydrolyzate and cerebroprotein hydrolyzate technology, which is applied in nervous system diseases, hydrolyzed protein components, peptide/protein components, etc., can solve the problems of low oral utilization and allergies of cerebroprotein hydrolyzate, and achieve high bioavailability , not prone to adverse reactions, the effect of reducing the dose

Active Publication Date: 2022-02-11
黑龙江迪龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that the existing cerebroprotein hydrolyzate easily causes allergies and has low oral utilization rate, the present invention provides a compound preparation of cerebroprotein hydrolyzate for neuroprotection and nerve repair and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This example provides a compound preparation of cerebroprotein hydrolyzate for neuroprotection and nerve repair. The compound preparation is a preparation for nasal mucosa administration, containing 0.1 wt% of cerebroprotein hydrolyzate, and the cosolvent is Tween-80 0.1 wt%; stabilizer mannitol 0.1wt%; preservative ethylparaben 0.01wt%; pH buffer is phosphate buffer, its addition amount is to adjust the liquid pH to 6.0-7.0, and the balance is water for injection.

[0023] The preparation method of the cerebroprotein hydrolyzate compound preparation used for nerve protection and nerve repair in this embodiment is:

[0024] Dissolve the cosolvent, stabilizer and preservative in an appropriate amount of water for injection according to the percentage by weight to obtain a mixed solution, add the cerebroprotein hydrolyzate raw material drug into the mixed solution according to the percentage by weight, and dissolve it fully with phosphate buffer solution The pH of the liq...

Embodiment 2

[0027] This example provides a compound preparation of cerebroprotein hydrolyzate for neuroprotection and nerve repair. The compound preparation is a preparation for nasal mucosa administration, containing 0.1wt% of cerebroprotein hydrolyzate, and the cosolvent is Tween-80 2wt %, 1,2-propanediol 1wt%; stabilizer mannitol 0.1wt%; preservative ethylparaben 0.01wt%; absorption accelerator borneol 0.01wt%; The pH of the liquid is adjusted to 6.0-7.0, and the balance is water for injection.

[0028] The preparation method of the cerebroprotein hydrolyzate compound preparation used for nerve protection and nerve repair in this embodiment is:

[0029] Step 1. Grind borneol into a fine powder with a particle size of 100 meshes, dissolve the borneol fine powder in 1,2-propylene glycol, add Tween-80, and mix evenly to obtain an absorption accelerator solution;

[0030] Step 2, dissolve the obtained absorption enhancer solution, mannitol and ethylparaben in an appropriate amount of wate...

Embodiment 3

[0033] This example provides a compound preparation of cerebroprotein hydrolyzate for neuroprotection and nerve repair. The compound preparation is a preparation for nasal mucosa administration, containing 1 wt% of cerebroprotein hydrolyzate with a pretreated molecular weight of 1000 Da or less, and a cosolvent Tween-80 0.5wt%; stabilizer mannitol 1wt%; preservative benzalkonium chloride 0.02wt%; pH buffer is phosphate buffer, its addition is to adjust the liquid pH to 6.0 ~ 7.0, the balance is Water for Injection.

[0034] The preparation method of the cerebroprotein hydrolyzate compound preparation used for nerve protection and nerve repair in this embodiment is:

[0035] Step 1, cerebroprotein hydrolyzate raw material drug pretreatment: dissolve cerebroprotein hydrolyzate raw material drug in deionized water of 2 to 5 times the weight, filter with a molecular weight cut-off 1000Da nanofiltration membrane, collect the filtrate, freeze-dry the obtained molecular weight at Br...

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Abstract

The invention relates to a brain protein hydrolyzate compound preparation for nerve protection and nerve repair and a preparation method thereof, belonging to the technical field of pharmacy. In order to solve the problem that the existing cerebroprotein hydrolyzate easily causes allergies and the oral utilization rate is low, the present invention provides a compound preparation of cerebroprotein hydrolyzate for neuroprotection and nerve repair, and the compound preparation is nasal mucosa administration preparation , containing 0.1-5wt% of cerebroprotein hydrolyzate, and also containing pharmaceutical auxiliary materials and water for injection. Administered through the nasal cavity, absorbed through the nasal mucosa, it can be absorbed into the brain in the respiratory area and olfactory area of ​​the nasal cavity, and directly enter the central nervous system. It has the characteristics of rapid absorption, high bioavailability, small side effects, and convenient administration. In the present invention, the brain protein hydrolyzate is made into nano-scale liposomes, so that the active ingredients are more easily absorbed through the mucous membranes, efficiently enter the brain cells and play a role, can maintain the local drug concentration stably for a long time, reduce the drug dosage, and are not easy to cause adverse effects on the body. reaction.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a cerebroprotein hydrolyzate compound preparation for nerve protection and nerve repair and a preparation method thereof. Background technique [0002] Cerebroprotein hydrolyzate is an aqueous solution of a mixture of various amino acids and low-molecular-weight peptides obtained by enzymatic hydrolysis of animal brain tissue proteins. It is a unique peptide energy neurotrophic drug for the brain, which can act on the central nervous system, regulate and improve neurons. metabolism, promote the formation of synapses, induce the differentiation of neurons, and further protect nerve cells from various ischemia and neurotoxin damage. Cerebroprotein hydrolyzate can be used for primary dementia, such as Alzheimer's disease; vascular dementia, such as multi-infarct dementia; it can also be used for brain function after organic cerebral neurological syndrome, traumatic brai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K9/00A61K38/01A61K47/10A61K47/24A61K47/26A61K47/28A61P25/00A61P25/28
CPCA61K38/012A61K47/26A61K47/10A61K9/1277A61K9/0043A61K47/24A61K47/28A61P25/00A61P25/28
Inventor 董继胜杨久春于芳王永义胡国庆
Owner 黑龙江迪龙制药有限公司
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