Nano liver target direction amphipathic nature block copolymers drug administration system and preparation

A technology of amphiphilic block and drug delivery system, which is applied in the field of nano-liver targeted amphiphilic block copolymer drug delivery system, can solve the problems of poor targeting and low bioavailability of anticancer drugs, and achieve maintenance The effect of drug activity, increasing curative effect and reducing adverse reactions
CN101249266AInactive Publication Date: 2008-08-27NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANKAI UNIV
Publication Date
2008-08-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a drug delivery system of nanometer liver targeting amphiphilic block copolymer and a preparation method thereof. The nanometer liver targeting drug delivery system is obtained by adopting liver targeting amphiphilic block copolymer which can be biologically degraded and which has good biocompatibility as the carrier material and embedding drugs for treating liver diseases by a solvent dialysis method or a solvent evaporation method; the weight ratio of the carrier material to the drug is 1:0.1 to 1.2. The drug delivery system has the advantages of simple operation, mild condition and cheap raw material; the prepared drug delivery system has good biocompatibility and both effects of active targeting and passive targeting, and can realize high targeting and sustained release drug delivery to the liver by means of injection, thus solving the defects of bad targeting and low bioavailability of present anticancer drugs and improving the life quality of patients, with broad application prospects.
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Description

technical field

[0001] The invention relates to a biodegradable nano-liver targeting amphiphilic block copolymer drug delivery system and a preparation method. The liver-targeting compound is modified onto the biodegradable and biocompatible amphiphilic block copolymer drug carrier, and the drug for the treatment of liver diseases is prepared by solvent dialysis or solvent evaporation to obtain nano-hepatic targeting compounds. Amphiphilic block copolymer drug delivery system. Background technique

[0002] The liver is the largest detoxification organ in the human body. It plays a vital role in the regulation of human metabolism, blood coagulation, immunity and other functions. Therefore, liver lesions seriously endanger human health. my country is a high-incidence area of ​​liver cancer, and the number of liver cancer patients is about 300,000 every year, accounting for 45% of the global liver cancer deaths. At present, liver transplantation is the first treatment for liv...

Claims

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