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High speed modulation sample imaging apparatus and method

A technology for equipment and samples, which is applied in particle imaging spectroscopy, preparation and sampling of samples for testing, etc., which can solve the problems that stage movement cannot be used to quickly create arbitrary scanning patterns, time-consuming stage, acceleration, etc.

Pending Publication Date: 2021-06-15
FLUIDIGM CANADA INC
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  • Claims
  • Application Information

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Problems solved by technology

However, these stages still have the disadvantage due to stage inertia, which means that it takes time to accelerate the stage to its maximum velocity during the imaging method
Stage inertia also means that stage movement cannot be used to quickly create arbitrary scan patterns

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  • High speed modulation sample imaging apparatus and method

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Embodiment Construction

[0055] Accordingly, various types of analyzer equipment, including laser scanner systems, may be used in practicing the present disclosure, many of which are discussed in detail below.

[0056] Analyzer equipment based on quality inspection

[0057] 1. Sampling and Ionization Systems

[0058] a. Laser ablation sampling and ionization system

[0059] Laser ablation-based analyzers typically contain three components. The first is a laser ablation sampling system used to generate a plume of gaseous and particulate matter from the sample to be analyzed. Before the atoms in the plume of ablated sample material (including any detectable label atoms as described below) can be detected by the detector system – mass spectrometer component (MS component; third component), the sample must be Ionize (and nebulize). Therefore, the device contains a second component, which is an ionization system that ionizes the atoms to form elemental ions so that they can be detected by the MS ...

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Abstract

This disclosure relates to systems and methods for high speed modulation sample imaging. Disclosed herein are systems and methods for performing imaging mass cytometry, including analysis of labelling atoms by elemental (e.g., atomic) mass spectrometry. Aspects include a sampling system having, and method of using, a femtosecond (fs) laser and / or laser scanning. Alternatively or in addition, aspects include systems and methods for co-registering other imaging modalities with imaging mass cytometry.

Description

[0001] Cross References to Related Applications [0002] This PCT application claims priority to U.S. Provisional Patent Application No. 62 / 729,241, filed September 10, 2018, and U.S. Provisional Patent Application No. 62 / 828,251, filed April 2, 2019, the entire contents of which are for all purposes Incorporated herein by reference. technical field [0003] The present invention involves imaging samples using imaging mass spectrometry (IMS) after laser ablation, and imaging mass cytometry (IMC TM ) to image biological samples. Background technique [0004] LA-ICP-MS (a form of IMS in which a sample is ablated by a laser, the ablated material is ionized in an inductively coupled plasma, and the ions are detected by mass spectrometry) has been used for the analysis of various substances such as geological Mineral analysis of samples, analysis of archaeological samples and imaging of biological material[i]. [0005] Imaging of biological samples by IMC has been previously r...

Claims

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Application Information

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IPC IPC(8): H01J49/04G01N1/28H01J49/02H01J49/06H01J49/26
CPCG01N2001/045G01N1/04H01J49/0004H01J49/0463G01N21/6428G01N21/6456G01N2021/6439
Inventor 达夫·桑德奎基尔亚历山大·洛博达阿达姆·卡鲁米纳利尼·拉克什曼
Owner FLUIDIGM CANADA INC
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