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Graft polymer and composite material containing the same

A composite material and polymer technology, applied in the field of grafted polymers, can solve problems such as uneven cost, reduce adsorption capacity and avoid sticking problems.

Pending Publication Date: 2021-06-29
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, if the surface treatment (such as plasma, ozone, corona, etc.) of metal electrodes with complex shapes is prone to problems such as unevenness and high cost

Method used

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  • Graft polymer and composite material containing the same
  • Graft polymer and composite material containing the same
  • Graft polymer and composite material containing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0047] Example 1-1: Preparation of grafted polymer product 1070326 PVABP

[0048] First, Nα-(tert-butoxycarbonyl)-L-histidine (BocHis, 3.54 g, 13.8 mmol) and 4-dimethylaminopyridine (DMAP, 1.54 g, 12.5 mmol) were added to dimethylacetamide ( After DMAc, 28mL), take 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, 2.41g, 12.5mmol) and quickly pour it into a reaction flask, and react at 60°C 3 hours to activate BocHis. Add polyvinyl alcohol (PVA, molecular weight 9,000-10,000, 2.2 g, 41.7 mmol, 80% hydrolyzed) into DMAc (22 mL), and stir at 80° C. for 2 hours until completely dissolved into a PVA solution. The activated BocHis solution was quickly added to the above PVA solution, and the reaction was continued at 90° C. for 24 hours to obtain a crude product solution. The -COOH group of the BocHis is esterified with the -OH group on the PVA, so that the BocHis is grafted onto the PVA. Next, put monomethoxypolyethylene glycol succinic acid (mPEG-SA, molecular weight 2,000,...

Embodiment 1-2

[0049] Example 1-2: Preparation of grafted polymer product 1070507PVABP

[0050] PVABP was prepared in the manner of Example 1-1, the only difference being that the amount of BocHis was changed to 17.7g (69.3mmol), the amount of DMAP was changed to 7.69g (63mmol), and the amount of EDC was changed to 12.0g (63mmol). As for the amount of mPEG-SA and PVA, the reaction temperature and time, and the method of purifying the crude product solution, they are similar to those in Example 1-1, and will not be repeated here. through 1 According to H-NMR measurement, the BocHis grafting rate of 1070507PVABP grafted polymer is 25%, and the mPEG-SA grafting rate is 1.5%.

Embodiment 1-3

[0051] Example 1-3: Preparation of grafted polymer product 1070521 PVABP

[0052]PVABP was prepared in the same manner as in Example 1-1, the difference being the amount of BocHis and mPEG-SA used. When preparing BocHis, its dosage was changed to 10.6g (41.6mmol), that of DMAP was changed to 4.6g (37.8mmol), and that of EDC was changed to 7.2g (37.8mmol). When preparing mPEG-SA, the dosage was changed to 20g (10mmol), the dosage of DMAP was changed to 1.0g (8.4mmol), and the dosage of EDC was changed to 1.6g (8.4mmol). As for the amount of PVA, the reaction temperature and time, and the method of purifying the crude product solution, they are similar to those in Example 1-1, and will not be repeated here. through 1 According to H-NMR measurement, the BocHis grafting rate of 1070521PVABP grafted polymer is 18%, and the mPEG-SA grafting rate is 1.0%.

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Abstract

A graft polymer is provided, which includes a polymer backbone with a plurality of hydroxy groups, protection group modified histidine grafted onto the side of the polymer backbone, and hydrophilic polymer having terminal reactive group grafted onto the side of the polymer backbone. The graft polymer coating can be applied to metal material to form a composite material, which can be implanted into an organism to reduce adhesion problems.

Description

technical field [0001] The present disclosure relates to grafted polymers, and more particularly to composite materials formed by coating metal materials with grafted polymers and methods of use thereof. Background technique [0002] According to statistics, more than 30 million patients around the world are currently suffering from severe lower back pain, and as the society enters an aging society, it is expected that there will be more related patients. According to the report of the research organization Global Market Insights on the electrical nerve stimulation equipment market, the market value of related products in 2017 was about 4 billion US dollars, and it is estimated that it will grow to 13 billion US dollars by 2023. The product market potential of the stimulator (Spinal cord stimulation, SCS) is the largest, and its output value is estimated to grow rapidly to more than US$9 billion in 2023. [0003] At present, implantable spinal cord stimulators have good cli...

Claims

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Application Information

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IPC IPC(8): C08G81/02A61L31/02A61L31/10A61L31/14
CPCC08G81/025A61L31/022A61L31/10A61L31/14A61L2400/18C08L87/005Y02P20/55C08F283/065C08F285/00
Inventor 施亭宇王嘉淳王律之游原坤江淑芳谢依婷刘于郡唐静雯
Owner IND TECH RES INST
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