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Composite preparation containing autologous collagen and application thereof

A collagen and composite preparation technology, applied in the field of cosmetic materials and plastic surgery, can solve problems such as absorption and residual incision scars, and achieve the effects of moderate degradation time, good biocompatibility, and high application safety.

Inactive Publication Date: 2021-07-09
白晋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Autologous cartilage is mostly taken from costal cartilage, nasal septal cartilage, and auricular cartilage. It has the advantages of no rejection and strong anti-infection ability. At the same time, there are defects of residual incision scar and partial absorption at the material removal site.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of the composite preparation containing autologous collagen in this example is as follows: add 0.012 g of calcium hydroxyapatite with a particle size of 40 μm and 0.04 g of autologous collagen to 10 ml of sodium acrylate, and disperse evenly by ultrasonic waves.

[0026] Wherein, the binder includes sodium carboxymethylcellulose, mannitol and physiological saline, and the weight ratio thereof is 1:2:6.

[0027] The preparation method of autologous collagen is as follows: the blood is collected from the human body through blood collection, the blood enters the whole blood separator after the first centrifugation, and second centrifugation is carried out in the whole blood separator, the whole blood centrifugation is divided into three layers, from top to bottom The plasma layer, the buffy coat layer and the red blood cell layer are followed by the plasma layer, the buffy coat layer and the red blood cell layer. The liquids of the plasma layer, the b...

Embodiment 2

[0029] The preparation method of the composite preparation containing autologous collagen in this example is as follows: add 0.015 g of calcium hydroxyapatite with a particle size of 25 μm and 0.036 g of autologous collagen to 10 ml of sodium acrylate, and disperse evenly by ultrasonic waves.

[0030] Wherein, the binder includes sodium carboxymethylcellulose, mannitol and physiological saline, and the weight ratio thereof is 1:3:8.

[0031] The preparation method of autologous collagen is as follows: the blood is collected from the human body through blood collection, the blood enters the whole blood separator after the first centrifugation, and second centrifugation is carried out in the whole blood separator, the whole blood centrifugation is divided into three layers, from top to bottom The plasma layer, the buffy coat layer and the red blood cell layer are followed by the plasma layer, the buffy coat layer and the red blood cell layer. The liquids of the plasma layer, the ...

Embodiment 3

[0033] The preparation method of the composite preparation containing autologous collagen in this example is as follows: add 0.01 g of calcium hydroxyapatite with a particle size of 35 μm and 0.06 g of autologous collagen to 10 ml of sodium acrylate, and disperse evenly by ultrasonic waves.

[0034] Wherein, the binder includes sodium carboxymethylcellulose, mannitol and physiological saline, and the weight ratio thereof is 1:2:7.

[0035] The preparation method of autologous collagen is as follows: the blood is collected from the human body through blood collection, the blood enters the whole blood separator after the first centrifugation, and second centrifugation is carried out in the whole blood separator, the whole blood centrifugation is divided into three layers, from top to bottom The plasma layer, the buffy coat layer and the red blood cell layer are followed by the plasma layer, the buffy coat layer and the red blood cell layer. The liquids of the plasma layer, the bu...

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PUM

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Abstract

The invention discloses a compound preparation containing autologous collagen. The compound preparation comprises calcium hydroxyapatite and the autologous collagen. The invention further discloses application of the compound preparation containing the autologous collagen. When the compound preparation is injected into a human body, autologous collagen is degraded and absorbed, meanwhile, autologous fibroblast proliferation can be stimulated, calcium hydroxylapatite serves as a scaffold for fibroblast inward growth, new collagen tissue is generated. The compound preparation provided by the embodiment of the invention has good biocompatibility, good stability and no migration property, can keep fixed volume and flexibility, and is not easy to deform under external force, the transplanted tissue is ideal in appearance and hardness, and the rhinoplasty effect is lasting.

Description

[0001] This application is a divisional application with an application date of August 27, 2018, an application number of 201810978561.7, and an invention title of "A Composite Preparation Containing Autologous Collagen and Its Application". technical field [0002] The invention relates to the technical field of plastic and cosmetic materials, in particular to a composite preparation containing autologous collagen and its application. Background technique [0003] With the improvement of social and economic level and the rapid development of the plastic surgery profession, the majority of beauty seekers have more and more demands for facial beauty. Because the nose is located in the center of the face, it is called the "soul of the five senses", which directly affects the contour and three-dimensionality of the face. Compared with Westerners, the nose shape of Asians is lower and flatter, and the nose tip is more rounded. With a straight nose, rhinoplasty came into being. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/12A61L27/20A61L27/50A61L27/58
CPCA61L27/12A61L27/20A61L27/24A61L27/50A61L27/58C08L1/286
Inventor 白晋
Owner 白晋