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Skin refreshing lotion, preparation method of skin refreshing lotion and collagenase inhibitor

A technology of collagenase and inhibitor, which is applied in the field of skin revitalizing lotion and its preparation method and collagenase inhibitor, which can solve problems such as difficulty, and achieve the effect of improving skin elasticity, simple operation, and excellent inhibitory effect

Pending Publication Date: 2021-07-16
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin, etc.

Method used

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  • Skin refreshing lotion, preparation method of skin refreshing lotion and collagenase inhibitor
  • Skin refreshing lotion, preparation method of skin refreshing lotion and collagenase inhibitor
  • Skin refreshing lotion, preparation method of skin refreshing lotion and collagenase inhibitor

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preparation example Construction

[0043] The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the ginseng extract and the chamomile extract are uniformly mixed in a conventional mixing manner.

[0044] Collagenase

[0045] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and maintain the stru...

Embodiment

[0095] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0096] It should be noted that different batches of purchased extracts will have corresponding errors, and the general error will not exceed 5%.

[0097] Ginseng extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.;

[0098] Chamomile extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.

Embodiment 1-5

[0104] Ginseng extract and chamomile extract are provided as collagenase inhibitors. Ginseng extract and chamomile extract are in mass ratio 3:1 (Example 1), 2:1 (Example 2), 1:1 (Example 3), 1:2 (Example 4), 1:3 (Example 5) After mixing, a collagenase inhibitor was obtained.

[0105] The collagenase inhibitor of Example 1 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0106] The collagenase inhibitors of Example 2 were dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0107] The collagenase inhibitor of Example 3 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0108] The collagenase inhibitor of Example 4 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0109] The collagenase inhibitor of Example 5 was dissolved in 5 groups of deionized water respectively to obta...

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Abstract

The invention provides a skin refreshing lotion, a preparation method of the skin refreshing lotion and a collagenase inhibitor. The skin refreshing lotion comprises the collagenase inhibitor and a penetration enhancer; the addition amount of the collagenase inhibitor is 0.01-10% based on the total mass of the skin refreshing lotion; the addition amount of the penetration enhancer is 0.01-10%; and the collagenase inhibitor comprises a ginseng extract and a chamomile extract, based on the total mass of the collagenase inhibitor, the addition amount of the ginseng extract is 30-70%, and the addition amount of the chamomile extract is 30-70%. According to the present invention, the formula of the skin refreshing lotion is mild, and the skin elasticity can be effectively improved, so that the anti-aging effect is achieved.

Description

technical field [0001] The invention relates to a body revitalizing lotion, a preparation method thereof and a collagenase inhibitor, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of skin collagen, increase the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/37A61K8/34A61K8/67A61K8/99A61K8/68A61K8/9711A61K8/73A61Q19/08A61Q19/00
CPCA61K8/9789A61K8/375A61K8/345A61K8/678A61K8/99A61K8/68A61K8/9711A61K8/34A61K8/73A61Q19/08A61Q19/00A61K2800/782A61K2800/5922A61K2800/592
Inventor 杨登亮李传茂谢佩佩张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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