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Moisture dew, collagenase inhibitor and preparation method of water dew and collagenase inhibitor

A collagenase and inhibitor technology, applied in the field of water dew and collagenase inhibitor and its preparation, can solve problems such as difficulty, and achieve the effects of improving skin elasticity, easy raw materials and mild formula

Pending Publication Date: 2021-07-16
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin, etc.

Method used

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  • Moisture dew, collagenase inhibitor and preparation method of water dew and collagenase inhibitor
  • Moisture dew, collagenase inhibitor and preparation method of water dew and collagenase inhibitor
  • Moisture dew, collagenase inhibitor and preparation method of water dew and collagenase inhibitor

Examples

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preparation example Construction

[0043]The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and can be a method commonly used in the art, which may specifically include the step of mixing the various components of the collagenase inhibitor. For example, the Poria cocos extract and the ginseng extract are uniformly mixed in a conventional mixing manner.

[0044] Collagenase

[0045] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinases, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its Tissue Inhibitors of Metalloproteinase (TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site. , together to regulate matrix metabolism and maintain the structure of t...

Embodiment

[0094] The embodiments of the present invention will be described in detail below with reference to the examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be regarded as limiting the scope of the present invention. If the specific conditions are not indicated in the examples, it is carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used without the manufacturer's indication are conventional products that can be obtained from the market.

[0095] Poria cocos extract was purchased from: Nanjing Speck Biochemical Industry Co., Ltd.;

[0096] Ginseng extract was purchased from: Zhenyue (Guangdong) Technology Research and Development Co., Ltd.

Embodiment 1-5

[0102] Poria cocos extract and ginseng extract are provided as collagenase inhibitors. Poria cocos extract and ginseng extract were mass ratio 1:10 (Example 1), 1:5 (Example 2), 1:3 (Example 3), 1:1 (Example 4), 2:1 (Example 5) After mixing, a collagenase inhibitor was obtained.

[0103] The collagenase inhibitors of Example 1 were respectively dissolved in 5 groups of deionized water to obtain 5 groups of test solutions. The concentrations of the 5 groups of test solutions were 2000 μg / mL, 1600 μg / mL, 1200 μg / mL, 800 μg / mL, 400 μg / mL, respectively. mL.

[0104] The collagenase inhibitors of Example 2 were respectively dissolved in 5 groups of deionized water to obtain 5 groups of test solutions, and the concentrations of the 5 groups of test solutions were 2000 μg / mL, 1600 μg / mL, 1200 μg / mL, 800 μg / mL, 400 μg / mL, respectively. mL.

[0105] The collagenase inhibitors of Example 3 were respectively dissolved in 5 groups of deionized water to obtain 5 groups of test solutions...

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Abstract

The invention provides a moisture dew, a collagenase inhibitor and a preparation method of the water dew and the collagenase inhibitor. The moisture dew comprises the collagenase inhibitor and a penetration enhancer, and the addition amount of the collagenase inhibitor is 0.01-10% based on the total mass of the moisture dew; the addition amount of the penetration enhancer is 0.01-10%; and the collagenase inhibitor comprises a poria cocos extract and a ginseng extract, based on the total mass of the collagenase inhibitor, the addition amount of the poria cocos extract is 10-45%, and the addition amount of the ginseng extract is 55-90%. According to the present invention, the moisture dew is mild in formula and can effectively improve skin elasticity, so that the anti-aging effect is achieved.

Description

technical field [0001] The invention relates to a water dew and collagenase inhibitor and a preparation method thereof, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It maintains the structure of the skin and gives the skin its toughness and elasticity. The content and distribution of collagen determines whether the skin is young or not. However, abnormal reduction of collagen content can cause thinning of the dermis, sagging skin, loss of elasticity, and wrinkles, affecting people's quality of life. With the deepening of collagen research, researchers found that collagenase plays an important role in the dynamic balance of skin collagen, and its overexpression and abnormal activation are one of the main reasons for skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of skin collagen, increase the content of collagen, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/9728A61K8/34A61K8/73A61K8/37A61Q19/08A61Q19/00
CPCA61K8/9789A61K8/9728A61K8/345A61K8/736A61K8/37A61Q19/08A61Q19/00A61K2800/782A61K2800/592
Inventor 杨登亮李华真李传茂张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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