Oxybutynin transdermal plaster and preparation method thereof

A technology of transdermal plaster and ointment, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, etc., which can solve the problem of limited drug effect duration of gel, slow drug release speed, Harm skin health and other problems, to achieve the effect of prolonging the duration of the drug effect, prolonging the application time, and increasing the porosity
CN113143891AActive Publication Date: 2021-07-23杭州仁德药业股份有限公司
4 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
杭州仁德药业股份有限公司
Publication Date
2021-07-23

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The invention relates to the technical field of pharmaceutical preparations, and discloses an oxybutynin transdermal plaster and a preparation method thereof. The oxybutynin transdermal plaster comprises a backing layer and an ointment-containing body, wherein the ointment-containing body comprises the following raw materials in percentage by mass: 3-5% of oxybutynin and / or pharmaceutically acceptable salt thereof, 10-15% of sodium polyacrylate, 5-8% of pre-crosslinked pectin, 1-2% of hydroxypropyl methylcellulose, 0.5-1% of dihydroxyaluminium aminoacetate, 1.5-3.5% of pectinase @ ethyl cellulose / chitosan microcapsule, 10-15% of sorbitol, 1-2% of laurinol azone, 10-15% of ethanol and the balance water; and the pH value of the ointment-containing body is controlled to be 5.0-6.0 by a pH regulator. The oxybutynin transdermal plaster disclosed by the invention has relatively high air permeability, and can promote the release of oxybutynin by slowly releasing pectinase in the later period of application, thereby prolonging the drug effect duration and application time of the plaster.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an oxybutynin transdermal plaster and a preparation method thereof. Background technique

[0002] Oxybutynin (OB), also known as urodolin, has a chemical name of 4-(diethylamino)but-2-yn-1-ylcyclohexyl(hydroxy)phenylacetate, which is a kind of The anti-smooth muscle spasm drug with anticholinergic effect has a strong selective effect on urinary and reproductive tract smooth muscle, can increase bladder capacity and each urination volume, reduce involuntary bladder contraction and prolong the interval between two urinations. Clinical indications include various urgency, frequency, incontinence, enuresis, etc. It is most suitable for frequent urination symptoms caused by cystitis, urethritis and recurrent urinary tract infection.

[0003] Oxybutynin has very little side effects on the cardiovascular system and central nervous system, but because the oral saliva...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More