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Veterinary cefquinome nanogel and preparation method thereof
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A cefquinoxime and nanogel technology, which is applied in the field of veterinary cefquinoxime nanogel and its preparation, can solve the problem that antibiotics are difficult to remove bacteria, long-term and repeated infection of dairy cows, and drug resistance of small colony variants. and other problems, to reduce the cost of treatment, enhance the ability of intracellular transport, and reduce the amount of use
Active Publication Date: 2021-07-27
TARIM UNIV
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Problems solved by technology
However, due to the biological barrier of the cell membrane, it is difficult for antibacterial drugs to remove bacteria
At the same time, subtherapeutic doses of antimicrobials are more likely to make small colony variants resistant
More importantly, as a persistent pathogenpool, small colony variants may cause long-term and repeated infection of dairy cows, often leading to failure of clinical treatment of dairy cow mastitis
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[0047] A preparation method for veterinary cefquinome nanogel, comprising the following steps:
[0048] S110, divide the distilled water into two parts, namely distilled water 1 and distilled water 2, add the cationic drug carrier into the distilled water 1, heat and dissolve to obtain a solution 1;
[0049] S120. Add cefquinome dropwise to solution 1, stir at high speed while adding dropwise, and mix evenly to obtain solution 2;
[0050] S130, adding the ionic cross-linking agent dropwise into solution 2, stirring at high speed while adding dropwise, and mixing evenly to obtain solution 3;
[0051] S140, adding the anionic drug carrier into the distilled water 2, heating and dissolving to obtain a solution 4;
[0052] S150, adding solution 3 into solution 4 dropwise, and stirring at the same time, so that the two are evenly mixed to obtain a premixed solution, and continue to stir the premixed solution to spontaneously form a nanogel to obtain cefquinome nanogel.
[0053] T...
Embodiment 1
[0059] It consists of the following raw materials in parts by mass: 2.5 parts of chitosan;
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Abstract
The invention discloses veterinary cefquinomenanogel and a preparation method thereof. The veterinary cefquinomenanogel is prepared from the following raw materials in parts by mass: 3-10 parts of a cationic drug carrier; 5-15 parts of an anionic drug carrier; 0.25-2 parts of an ionic cross-linking agent; 40-95 parts of distilled water; and 0.5-3 parts of cefquinome. The invention has the beneficial effects that by combining the advantages of a nanotechnology and a gel technology, the intracellular transport capacity of an antibacterial drug is enhanced, and the antibacterial activity on pathogenic bacteria is enhanced; the manufacturing process is simple and convenient to produce; and the clinical use amount of the cefquinome can be reduced, so that the treatment cost of the cow mastitis is reduced.
Description
technical field [0001] The invention relates to the technical field of veterinary drug preparation, in particular to a veterinary cefquinome nanogel and a preparation method thereof. Background technique [0002] As the fourth-generation cephalosporin antibiotic, cefquinome has a broad antibacterial spectrum, strong antibacterial activity, and is suitable for parenteral administration. It is especially suitable for the treatment of mastitis in dairy cows. It can be used to inhibit common Gram-positive and negative bacteria. Including Escherichia coli, Klebsiella, Pasteurella, Proteus, Salmonella, Staphylococcus aureus, Streptococcus and Erysipelas suis. [0003] Staphylococcus aureus is an important pathogen that causes mastitis in dairy cows. As a facultativeintracellular parasite, under the action of antibacterial drugs, it develops from a normal state to a small colony mutant strain, which is more easily absorbed by cells. The way of colony mutants survives in the host ...
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Application Information
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