Probiotic gel for recovering and stabilizing vaginal microbial florae, and preparation method thereof

A technology of microbial flora and probiotics, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc., can solve double infection of the central nervous system, damage Beneficial bacteria in the reproductive tract, high recurrence rate and other issues

Pending Publication Date: 2021-07-30
济南万泉生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics have a high cure rate, but at the same time destroy the beneficial flora of the reproductive tract, change the microbial dominance, and cause a large number of drug-resistant pathogenic microorganisms to appear. toxicity

Method used

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  • Probiotic gel for recovering and stabilizing vaginal microbial florae, and preparation method thereof
  • Probiotic gel for recovering and stabilizing vaginal microbial florae, and preparation method thereof
  • Probiotic gel for recovering and stabilizing vaginal microbial florae, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of a probiotic gel for restoring and stabilizing private microbial flora, the formula of which is as follows:

[0028] Carbomer U20 0.75 %

[0029] Recombinant Human Collagen 0.75 %

[0030] Hyaluronic Acid 1.0 %

[0031] Propylene glycol 1.0 %

[0032] Bifidobacterium lysate liposome lyophilized powder 1.5 %

[0033] Lactobacillus fermentum 0.5 %

[0034] Lactobacillus reuteri 0.5 %

[0035] Lactobacillus rhamnosus 0.5 %

[0036] Lactobacillus acidophilus 0.5 %

[0037] Peppermint Extract 0.05 %

[0038] Purified water 93.7 %

[0039] Cecropin 0.01%

[0040] The hyaluronic acid is high-molecular hyaluronic acid with a relative molecular mass of 1.6 million Da, middle-molecular hyaluronic acid with a relative molecular mass of 100,000 Da, and low-molecular hyaluronic acid with a relative molecular mass of 80,000 Da. Mixture, the ratio of the three is 2:1:1.

[0041] The preparation process of described bifidobacterium lysate liposome lyop...

Embodiment 2

[0046] A preparation method of a probiotic gel for restoring and stabilizing private microbial flora, the formula of which is as follows:

[0047] Carbomer U20 1.0 %

[0048] Recombinant Human Collagen 1.0 %

[0049] Hyaluronic Acid 0.5 %

[0050] Propylene glycol 2.0 %

[0051] Bifidobacterium lysate liposome lyophilized powder 1 %

[0052] Lactobacillus fermentum 0.5 %

[0053] Lactobacillus reuteri 0.5 %

[0054] Lactobacillus rhamnosus 0.5 %

[0055] Lactobacillus acidophilus 0.5 %

[0056] Peppermint Extract 0.05 %

[0057] Purified water 93.45 %

[0058] Cecropin 0.01%

[0059] The hyaluronic acid is high-molecular hyaluronic acid with a relative molecular mass of 1.7 million Da, middle molecular hyaluronic acid with a relative molecular mass of 700,000 Da, and low-molecular hyaluronic acid with a relative molecular mass of 90,000 Da. Mixture, the ratio of the three is 2:1:1.

[0060] The preparation process of the bifidobacterium lysate liposome freeze-dried po...

Embodiment 3

[0065] A preparation method of a probiotic gel for restoring and stabilizing private microbial flora, the formula of which is as follows:

[0066] Carbomer U20 1.0 %

[0067] Recombinant Human Collagen 1.2 %

[0068] Hyaluronic Acid 0.5 %

[0069] Propylene glycol 1.5 %

[0070] Bifidobacterium lysate liposome lyophilized powder 2.0 %

[0071] Lactobacillus fermentum 0.4 %

[0072] Lactobacillus reuteri 0.4 %

[0073] Lactobacillus rhamnosus 0.4 %

[0074] Lactobacillus acidophilus 0.4 %

[0075] Peppermint Extract 0.05 %

[0076] Purified water 93.45 %

[0077] Cecropin 0.01%

[0078] The hyaluronic acid is high-molecular hyaluronic acid with a relative molecular mass of 1.5 million Da, middle molecular hyaluronic acid with a relative molecular mass of 400,000 Da, and low-molecular hyaluronic acid with a relative molecular mass of 100,000 Da. Mixture, the ratio of the three is 2:1:1.

[0079] The preparation process of the bifidobacterium lysate liposome freeze-dri...

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Abstract

The invention belongs to the field of microbial products, and relates to a gel for female private parts, and concretely relates to a probiotic gel for recovering and stabilizing vaginal microbial florae, and a preparation method thereof. The probiotic gel comprises, by weight, 0.5 to 1.0 percent of carbomer U20, 0.5 to 2.0 percent of hyaluronic acid, 0.3 to 1.0 percent of recombinant human collagen, 0.5 to 2.0 percent of propylene glycol, 1 to 2 percent of bifidobacterium lysate liposome freeze-dried powder, 0.1 to 1.0 percent of lactobacillus fermentum, 0.1 to 1 percent of lactobacillus reuteri, 0.1 to 1.0 percent of lactobacillus rhamnosus, 0.1 to 1 percent of lactobacillus acidophilus, 0.01 to 0.1 percent of mint extract, 0.004 to 0.02 percent of antibacterial peptide, and the balance of purified water. By adding the bifidobacterium lysate, the lysate has a good effect on killing pathogenic bacteria and can stably play a role for a long time; and by adding the recombinant human collagen, the collagen has a good effect in promoting colonization of the probiotics, so that the probiotics can better tolerate inflammatory stress and survive.

Description

technical field [0001] The invention belongs to the field of microbial products, and relates to a gel for women's private parts, in particular to a probiotic gel for restoring and stabilizing vaginal microbial flora and a preparation method thereof. Background technique [0002] The normal reproductive tract ecology is composed of microecological flora, collective endocrine regulation and anatomical structure in the reproductive tract. The female genital tract flora is dominated by Gram-positive Lactobacillus. Studies have shown that Lactobacillus decomposes and guides the glycogen in the mucosal epithelium to produce lactic acid, maintains and guides the pH at 3.8 to 4.4, and can effectively inhibit the growth of other pathogenic bacteria. Breeding and reproduction, maintaining the ecological balance of the reproductive tract. [0003] Reproductive tract infection (RTI) is caused by the invasion of various pathogenic microorganisms during medical operations or sexual life....

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K38/39A61K35/747A61K35/745A61K9/06A61K47/36A61K47/42A61P15/00A61P31/04A61P31/10
CPCA61K35/747A61K35/745A61K38/39A61K36/534A61K38/1703A61K47/42A61K47/36A61K9/06A61K9/0034A61P31/04A61P15/00A61P31/10
Inventor 赵莎莎戴晓宇李栋
Owner 济南万泉生物技术有限公司
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