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Multifunctional closed hemostasis wound dressing and preparation method thereof

A wound dressing and a multi-functional technology, applied in the field of composite hemostatic materials and their preparation, can solve the problems of being unsuitable for mass production and cumbersome preparation steps, etc., to meet the requirements of large-dose bleeding, improve diffusivity, and enhance good tensile properties Effect

Active Publication Date: 2021-08-06
福州博美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic material prepared by this technical scheme has good biocompatibility, safety and non-toxicity; it can rapidly promote blood coagulation, and can complete rapid hemostasis within a certain application range, but it has no adhesion to wet tissues and is not suitable for large arterial bleeding and visceral bleeding
And its preparation steps are also comparatively loaded down with trivial details, not suitable for mass production

Method used

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  • Multifunctional closed hemostasis wound dressing and preparation method thereof
  • Multifunctional closed hemostasis wound dressing and preparation method thereof
  • Multifunctional closed hemostasis wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method of a novel wound dressing for multifunctional sealing and hemostasis, comprising the following steps:

[0033] (1) Dissolve 15 g of aluminum chloride hexahydrate in water, add 15 g of chitosan, and stir at 40°C for 6 h to obtain solution S1, in which the concentration of chitosan is 0.67 g / mL, and the concentration of aluminum chloride hexahydrate is 0.67 g / mL.

[0034] (2) Add 2 g of PVA to deionized water, stir at 40°C for 4 h, then add 25 mg of BSA and 10 mg of coagulation factor to dissolve to obtain nanoparticle solution S2 loaded with coagulation factor, in which the mass fraction of polyvinyl alcohol is 2% , The mass fraction of bovine serum albumin is 0.025%, and the mass fraction of coagulation factors is 0.01%;

[0035] (3) Dissolve 250 mg of PCL (polycaprolactone) in dichloromethane, stir at a temperature of 30°C, and stir for 4 hours to obtain a solution S3, in which the mass fraction of polycaprolactone is 3%;

[0036](4) Use a probe-...

Embodiment 2

[0041] A preparation method of a novel wound dressing for multifunctional sealing and hemostasis, comprising the following steps:

[0042] (1) Dissolve 20 g of aluminum chloride hexahydrate in water, add 20 g of chitosan, and stir at 45°C for 4 h to obtain solution S1, in which the concentration of chitosan is 1 g / mL; the concentration of aluminum chloride hexahydrate 1 g / mL;

[0043] (2) Add 4 g of PVA to deionized water, stir at 35°C for 4 hours, then add 25 mg of BSA and 10 mg of coagulation factor to dissolve to obtain solution S2, in which the mass fraction of polyvinyl alcohol is 4%, the mass fraction of bovine serum albumin The fraction is 0.025%, and the mass fraction of coagulation factor is 0.01%;

[0044] (3) Dissolve 100 mg of PCL in dichloromethane; stir at 30°C for 4 h to obtain solution S3, in which the mass fraction of polycaprolactone is 1%;

[0045] (4) Use a probe-type ultrasonic homogenizer to emulsify solution S2 in solution S3, and then stir with a magn...

Embodiment 3

[0050] A preparation method of a novel wound dressing for multifunctional sealing and hemostasis, comprising the following steps:

[0051] (1) Dissolve 20 g of aluminum chloride hexahydrate in water, add 20 g of chitosan, and stir at 45°C for 4 h to obtain solution S1, in which the concentration of chitosan is 1 g / mL, and the concentration of aluminum chloride hexahydrate 1 g / mL;

[0052] (2) Add 2 g of PVA to deionized water, stir at 45 °C for 4 h, then add 30 mg of BSA and 15 mg of coagulation factor to dissolve to obtain solution S2, in which the mass fraction of polyvinyl alcohol is 4%, bovine serum albumin The mass fraction is 0.03%, and the mass fraction of coagulation factors is 0.015%;

[0053] (3) Dissolve 200 mg of PCL in dichloromethane; stir at 35°C for 3.5 h to obtain solution S3, in which the mass fraction of polycaprolactone is 2%;

[0054] (4) Use a probe-type ultrasonic homogenizer to emulsify the solution S2 in the solution S3, and stir with a magnetic stir...

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Abstract

The invention discloses a multifunctional closed hemostasis wound dressing which is prepared by uniformly mixing chitosan, nanoparticles loaded with blood coagulation factors, pluronic F-127 and catechol under the condition of the room temperature. The multifunctional closed hemostasis wound dressing provided by the invention is high in bonding speed in a wet environment, has the advantages of high hemostasis efficiency, high antibacterial activity, safety, non-toxicity, good biocompatibility, low price, convenience in operation and the like, is suitable for arterial hemostasis, is simple in preparation method and can be produced on a large scale.

Description

technical field [0001] The invention belongs to the field of biological material preparation and biomedical application, and in particular relates to a composite hemostatic material prepared from nanoparticles loaded with coagulation factors, Pluronic F-127, chitosan and catechol and a preparation method thereof. Background technique [0002] The research and development of a new generation of high-efficiency hemostatic materials to meet the needs of our army for step-by-step treatment and high hemostasis has always been an urgent research hotspot in today's military support and clinical medicine. At present, the hemostatic materials on the market mainly include fibrin glue, oxidized regenerated cellulose, cyanoacrylate, zeolite and chitosan. When zeolite absorbs water, it will release a lot of heat, which will cause more serious thermal damage and burns to the injured tissue. For example, the hemostatic material of Quikclot developed by Z-Medica Company is a composite type ...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/24C08J3/075C08L5/08
CPCC08J3/24C08J3/075A61L26/008A61L26/0023A61L26/0066A61L26/0019A61L26/0047C08J2305/08A61L2400/04A61L2300/252A61L2300/236A61L2300/624A61L2300/404C08L5/08
Inventor 李飞翰杨黄浩张进潘高星林倩潘佳铭刘泽群
Owner 福州博美生物科技有限公司
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