Methods of inhibiting neutrophil recruitment to the gingival crevice

A neutrophil and protein technology, applied in non-central analgesics, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of destroying bones and tissues that support teeth

Pending Publication Date: 2021-08-06
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As an unfortunate consequence, these elements can inadvertently destroy the bone and tissue that support the teeth

Method used

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  • Methods of inhibiting neutrophil recruitment to the gingival crevice
  • Methods of inhibiting neutrophil recruitment to the gingival crevice
  • Methods of inhibiting neutrophil recruitment to the gingival crevice

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0055] figure 1 Contains an illustration of the gingival crevasse model (GCM). GCM can be used to assess product health benefits in a cell culture model that closely mimics the gingival crevice. The crevasse is home to hundreds of bacterial species as well as gingival epithelial cells and neutrophils. Proteomics, bacterial effects and odor of secreted or expressed proteins can be evaluated and used to compare the effects of various compounds and compositions. GCM incorporates three components: neutrophil-like cells, biofilm containing oral bacteria, and oral epithelium.

[0056] Neutrophil-like cells: HL60 cells (ATCC #CCLO-240) can be induced to differentiate into a neutrophil-like cell type by exposing HL60 cells to retinoic acid. HL60 cells were maintained at 1x10 5 Cell density of cells / mL (medium for HL60IMEM ATCC#30-2005). Retinoic acid used to differentiate HL60 into neutrophil-like cells was prepared by dissolving retinoic acid in ETOH to generate a 1 mM ethanol s...

Embodiment 2

[0075] Oral compositions comprising arginine are disclosed in WO / 2011 / 123123, which corresponds to US 8,652,495, both of which are incorporated herein by reference. In some embodiments, an oral care composition comprises an orally acceptable vehicle; zinc oxide particles; and arginine. In some such embodiments, the zinc oxide particles have a median particle size of 1 micron to 7 microns; in some such embodiments, the zinc oxide particles have a particle size distribution of 3 microns to 4 microns, a particle size of 5 microns to 7 microns distribution, a particle size distribution of 3 microns to 5 microns, a particle size distribution of 2 microns to 5 microns, or a particle size distribution of 2 microns to 4 microns. In some of these various described embodiments, the zinc oxide particles are present in an amount of up to 5% by weight, such as 0.5% to 2% by weight, based on the total weight of the oral care composition. In some of these various described embodiments, the ...

Embodiment 3

[0077] Oral compositions comprising arginine are disclosed in WO 2014 / 088572, which corresponds to US 2015 / 0313813, both of which are incorporated herein by reference. In some embodiments, the oral care composition comprises: a source of zinc ions at about 0.05% to about 5% by weight; a source of fluoride ions in an amount effective to deliver fluoride from about 500 ppm to about 5,000 ppm; and about 0.1 % to about 10% by weight arginine. In some such embodiments, the source of zinc ions is selected from zinc citrate, zinc sulfate, zinc silicate, zinc lactate, zinc phosphate, zinc oxide, and combinations thereof, eg, in an amount effective to inhibit erosion. In some such embodiments, the oral composition is in the form of a dentifrice comprising abrasives. In some such embodiments, the amount of zinc is 0.5% to 4% by weight. In some such embodiments, the composition may also include one or more abrasives, one or more wetting agents, and one or more surfactants. In some suc...

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Abstract

Methods of increasing proteins that reduce signals associated with neutrophil recruitment and reducing proteins that induce neutrophil recruitment within an individual's gingival crevice are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase proteins that reduce signals associated with neutrophil recruitment and reduce proteins that induce neutrophil recruitment within an individual's gingival crevice, an oral care composition comprising: zinc oxide, zinc citrate, stannous fluoride, and optionally arginine and / or zingerone.

Description

Background technique [0001] Gums, also known as gums, are part of the soft tissue lining of the mouth that surrounds and provides a seal around teeth. The gingival margin is the interface between the gingival sulcus epithelium and the oral epithelium. This interface exists at the highest coronal point of the gingiva, also known as the coronal portion of the marginal gingiva. The gingival crevasse, also known as the gingival sulcus, is the space around a tooth located between the wall of unattached gum tissue and the enamel and / or cementum of the tooth. [0002] Gum disease is inflammation of the gum line that can progress to affect the bone that surrounds and supports the teeth. The three stages of gum disease (from mildest to most severe) are gingivitis, periodontitis, and severe periodontitis. [0003] Gingivitis is the initial stage of gum disease. The immediate cause of gingivitis is dental plaque, ie, the soft, sticky, colorless film of bacteria that persists on the t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/21A61K8/27A61K8/362A61P1/02A61P29/00A61Q11/00
CPCA61K8/27A61K8/21A61K8/19A61K8/362A61Q11/00A61P1/02A61P29/00
Inventor 卡米耶·泽诺比娅卡洛·德埃普陈丹丹哈什·马亨德拉·特里维迪詹姆斯·马斯特斯
Owner COLGATE PALMOLIVE CO
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