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Composite microbial preparation for treating type 2 diabetes and preparation process thereof

A technology of complex microorganisms and type 2 diabetes, which is applied in the field of medical pathology, can solve problems such as vitamin B12 deficiency, abnormal blood sugar metabolism, and increase treatment costs, and achieve the goals of lowering blood sugar levels, high therapeutic effects, and reducing drug resistance and stress response Effect

Inactive Publication Date: 2021-08-10
戚凤春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the case of type 2 diabetes, it is mainly caused by the gradual decrease in insulin secretion or insulin resistance. In this case, abnormal blood sugar metabolism occurs due to decreased insulin secretion or weakened effect. Compared with type 1 diabetes , Insulin in patients with type 2 diabetes may be in a normal working state, and the current hypoglycemic drugs mainly promote the secretion of insulin and speed up the processing of blood sugar, but there are obvious side effects when taking drugs, such as vitamin B12 deficiency, Combined treatment is required, on the one hand, it will increase the cost of treatment, and it will also cause the physical burden of the patient. Therefore, in order to solve such problems, we propose a compound microbial preparation for the treatment of type 2 diabetes and its preparation process

Method used

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  • Composite microbial preparation for treating type 2 diabetes and preparation process thereof
  • Composite microbial preparation for treating type 2 diabetes and preparation process thereof
  • Composite microbial preparation for treating type 2 diabetes and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] It includes three parts: maternal extraction sample, in vitro culture, and detection and quantitative cultivation. The maternal extraction sample part includes the following parts:

[0034] S1: Use endoscopic surgery to extract maternal gastrointestinal mucus for in vitro cultivation;

[0035] S2: Extract the anaerobic bacteria, Akkermansia, Clostridium tenenella and probiotics in the gastrointestinal mucus, mark and store them separately.

[0036] Include the following parts in the in vitro culture part:

[0037] N1: Place the extracted anaerobic bacteria, Akkermansia, Clostridium tenebilis and probiotics in slanted petri dishes for mass cultivation. After the cultivation is completed, store them in a refrigerator;

[0038] N2: Take maternal blood samples and divide them into several marked groups according to equal doses. Blood samples are also mixed for anaerobic bacteria, Akkermansia, Clostridium tenebilis and probiotics, and the measurement and marking of each mix...

Embodiment 2

[0041] The detection and quantitative cultivation part includes the following parts:

[0042] M1: Detection of biochemical indicators on maternal blood samples, including FBG, HDL-C, LDL-C, TC, TG, HbA1c and HOMA-IR;

[0043] M2: Mix the blood samples of the marked group with the compound microbial preparation, and after a period of refrigeration, test the biochemical indicators of the blood samples of the marked group again;

[0044] M3: Obtain the change value of the relevant biochemical indicators, select the optimal mixed group, and calculate the content of the compound microbial preparation according to the ratio of the drawn blood sample to the normal blood content of the mother*1:5.

[0045] Beneficial effects: the extracted microorganisms act on the patient's own blood sample, and detect various biochemical index parameters in the mixed blood sample, so that an optimal treatment plan can be obtained.

Embodiment 3

[0047] Mixed grouping in the N2 step, including the following combinations: anaerobic bacteria, Akkermansia, Clostridium tenebilis, probiotics, (anaerobic bacteria+Akkermansia), (anaerobic bacteria+Clostridium tenebilis ), (anaerobic bacteria + probiotics), (anaerobic bacteria + Akkermansia + Clostridium tenebilis), (anaerobic bacteria + Akkermansia + probiotics), (anaerobic bacteria + Clostridium tenebilis + probiotics), (Akkermansia + Clostridium tenebilis), (Akkermansia + probiotics), (Akkermansia + Clostridium tenebilis + probiotics) and (Clostridium tenebilis + probiotics ).

[0048] According to the combination above, list the parameter tables of various biochemical indicators, the table is as follows:

[0049]

[0050]

[0051]

[0052] In summary: in the present invention, for the treatment of type 2 diabetes, the method of microbial treatment is used, and the microorganisms used are derived from the patient itself. During the treatment process, the patient's d...

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Abstract

The invention discloses a composite microbial preparation for treating type 2 diabetes and a preparation process thereof. The microbial preparation contains one or more of anaerobic bacteria, ackermania, clostridium lepsii and probiotics, the anaerobic bacteria can decompose carbohydrates through carbohydrate active enzymes to obtain short-chain fatty acids, the short-chain fatty acid contains one or more of butyric acid, acetic acid and butyric acid, the short-chain fatty acid is used for reducing inflammatory response in intestinal tracts, and the Ackerman's bacteria are used for regulating fat storage, adipose tissue inflammation and controlling a glycometabolism function; and the Ackerman's bacteria are used for improving the sensitivity of insulin and improving the proliferation efficiency of other beneficial bacteria. In the treatment process of the type 2 diabetes, the drug resistance and stress response of a patient in the treatment process are reduced in a microbiological treatment mode, and a high treatment effect is achieved.

Description

technical field [0001] The invention relates to the technical field of medical pathology, in particular to a compound microbial preparation for treating type 2 diabetes and a preparation process thereof. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. Long-term high blood sugar, leading to various tissues, divided into type 1 diabetes and type 2 diabetes; [0003] In the case of type 2 diabetes, it is mainly caused by the gradual decrease in insulin secretion or insulin resistance. In this case, abnormal blood sugar metabolism occurs due to decreased insulin secretion or weakened effect. Compared with type 1 diabetes , Insulin in patients with type 2 diabetes may be in a normal working state, and the current hypoglycemic drugs mainly promote the secretion of insulin and speed up the processing of blood sugar, but there are o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/741A61P3/10A61K35/74
CPCA61K35/74A61K35/741A61P3/10A61K2300/00
Inventor 戚凤春戚文淏杨佳林崔燕平
Owner 戚凤春