Preparation method of 2-(trans-4-n-propyl cyclohexyl) propane-1, 3-diol

A technology of n-propyl and cyclohexane, applied in the field of preparation of 2-propane-1,3-diol, can solve problems such as dangerous processes, and achieve the effects of reducing side reactions, low cost and improving the yield of reduction reaction
CN113233958APending Publication Date: 2021-08-10FUYANG XINYIHUA MATERIAL TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUYANG XINYIHUA MATERIAL TECH
Publication Date
2021-08-10

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Abstract

The invention relates to the technical field of organic synthesis, in particular to a preparation method of 2-(trans-4-n-propyl cyclohexyl) propane-1, 3-diol. The preparation method comprises the steps of (i) carrying out bromination reaction on 4-n-propyl cyclohexanol and phosphorus tribromide to generate 1-bromo-4-n-propyl cyclohexane; (ii) sequentially adding diethyl malonate and 1-bromo-4-n-propyl cyclohexane into the ethanol solution of the lithium methoxide, and carrying out an alkylation reaction to generate 2-(4-n-propyl cyclohexyl)-diethyl malonate; and (iii) sequentially adding 2-(4-n-propyl cyclohexyl)-diethyl malonate, lithium chloride and potassium borohydride into the solvent, carrying out a reduction reaction to generate 2-(4-n-propyl cyclohexyl) propane-1, 3-diol, and carrying out recrystallization to obtain the 2-(trans-4-n-propyl cyclohexyl) propane-1, 3-diol. The method has the advantages of being safe, low in cost, environmentally friendly and suitable for industrial production.
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Description

technical field

[0001] The application relates to the technical field of organic synthesis, more specifically, it relates to a preparation method of 2-(trans-4-n-propylcyclohexyl)propane-1,3-diol. Background technique

[0002] In the liquid crystal industry, it is necessary to prepare liquid crystal mixtures with high resistivity, low power consumption, low driving threshold voltage and low viscosity, such as 2-(trans-4-n-propylcyclohexyl)propane-1,3 - Diols are among the organic materials that have proven suitable as intermediates for the preparation of liquid crystal mixtures.

[0003] Dangerous processes exist in the currently disclosed synthetic routes of products similar to 2-(trans-4-n-propylcyclohexyl)propane-1,3-diol. For example, the patent document with the authorized announcement date of April 29, 2015 and the authorized announcement number CN103524305B discloses a preparation method of 1,3-propanediol derivatives. As a starting material, trans-2-(4-n-propylcycl...

Claims

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