Plant extract composition with anti-allergy effect as well as preparation method and application thereof

A technology of plant extracts and compositions, applied in the directions of medical preparations, drug combinations, and plant raw materials containing active ingredients, can solve problems such as aggravating skin problems, abnormal pigmentation of acne, telangiectasia, etc., and achieve reliable resistance and relief. Effect, enhance the immune function of the body, inhibit the effect of allergy

Pending Publication Date: 2021-08-17
SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The medical treatment of sensitive skin is mainly to treat with drugs such as glucocorticoids and histamine receptor antagonists. These drugs can effectively relieve skin allergies or irritations, but if used repeatedly for a long time, these anti-skin allergy drugs will produce obvious side effects. For example, skin atrophy, telangiectasia, acne pigmentation abnormalities, etc., and long-term use of glucocorticoids will form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Measure Fenji 10g, Gentiana 30g and Glycyrrhizae 20g, use 20 times the amount [solution volume (ml): medical material weight (g)] containing 50% betaine-1,3-butanediol-1,2- The hexanediol (molar ratio is 1:2:2) deep eutectic solvent aqueous solution is soaked and extracted once at 30°C, and soaked for 2 hours each time to obtain the extract;

[0029] The extract is clarified by microfiltration through a ceramic membrane with a pore size of 500 nm to obtain a clarified liquid;

[0030] The clarified solution was concentrated by 1 time and then loaded onto a C18 reversed-phase chromatographic column (25×250mm, 10μm). The mobile phase is ethanol water with a flow rate of 20mL / min, using gradient elution; 0-15min, 10% ethanol; 15-25min, 20% ethanol; 25-35min, 50% ethanol, 35-65min, 100% ethanol. The detection wavelength is 237nm, and the target components are collected in sections according to the liquid phase detection results.

[0031] Concentrate the target fraction by...

Embodiment 2

[0034] Measure Fenji 5g, Gentian 40g and Licorice 10g, use 10 times the amount [solution volume (ml): medicine weight (g)] containing 70% betaine-1,3-butanediol-1,2- Hexylene glycol (molar ratio: 1:3:1) deep eutectic solvent aqueous solution was soaked and extracted twice at 80°C, soaked for 1 hour each time, to obtain the extract;

[0035] The extract is clarified by microfiltration through a ceramic membrane with a pore size of 100 nm to obtain a clarified liquid;

[0036] The clarified solution was concentrated 2 times and then loaded onto a C18 reverse-phase chromatographic column (25×250mm, 10μm). The mobile phase is methanol water with a flow rate of 20mL / min, using gradient elution; 0-15min, 10% methanol; 15-25min, 20% methanol; 25-35min, 50% methanol, 35-65min, 100% methanol. The detection wavelength is 237nm, and the target components are collected in sections according to the liquid phase detection results.

[0037] Concentrate the target fraction by 5 times, add 1...

Embodiment 3

[0040] Measure Fenji 40g, Gentiana 10g and Glycyrrhizae 20g, use 30 times the amount [solution volume (ml): medicinal material weight (g)] containing 30% betaine-1,3-butanediol-1,2- Hexylene glycol (molar ratio 1:4:2) deep eutectic solvent aqueous solution was soaked and extracted at 40°C for 3 times, each soaked for 1.5h, to obtain the extract;

[0041] The extract is clarified by microfiltration through a ceramic membrane with a pore size of 200 nm to obtain a clarified liquid;

[0042]The clarified solution was concentrated 5 times and then loaded onto a C18 reverse-phase chromatographic column (25×250mm, 10μm). The mobile phase is methanol water with a flow rate of 20mL / min, using gradient elution; 0-15min, 10% methanol; 15-25min, 20% methanol; 25-35min, 50% methanol, 35-65min, 100% methanol. The detection wavelength is 237nm, and the target components are collected in sections according to the liquid phase detection results.

[0043] Concentrate the target fraction by 8...

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Abstract

The invention relates to the technical field of cosmetics, and discloses a plant extract composition with an anti-allergy effect and a preparation method. The composition comprises, in percentage by weight, 1%-50% of the extract of radix stephaniae tetrandrae, 1%-50% of the extract of radix gentianae and 1%-50% of the extract of liquorice roots. The composition formed by compounding the plant extracts can inhibit allergic reaction from multiple ways and reduce inflammation, and the composition can more effectively exert anti-allergy effect; the plant extract composition with the anti-allergy effect is extracted by taking a deep eutectic solvent as an extraction solvent; and the method has the characteristic of high extraction efficiency compared with a traditional water extraction method or a simple water-alcohol combined extraction method, and the anti-allergy effect of the extract is more remarkable.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to an anti-allergic plant composition, its preparation method and application. Background technique [0002] In recent years, with changes in human diet, increased pressure in life, and increased air pollution, the number of people with skin allergies has increased sharply. Many respondents around the world feel that they have sensitive skin. Sensitive skin mostly appears on the face, and other parts of the body such as hands, feet, back, etc. may also appear. Especially the Asian population is more prone to sensitive skin problems. Sensitive skin is mainly manifested as brittle, thin, dry, peeling skin, dry skin, tightness, burning sensation, tingling, skin itching, erythema, and rash. [0003] The medical treatment of sensitive skin is mainly to treat with drugs such as glucocorticoids and histamine receptor antagonists. These drugs can effectively relieve skin allergies or ir...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/00A61K36/59A61P37/08A61P17/00
CPCA61K8/9789A61Q19/005A61K36/59A61K36/515A61K36/484A61P37/08A61P17/00A61K2800/782A61K2800/5922A61K2800/805A61K2300/00
Inventor 李远彬张嘉恒徐美禄丘彩妮陈一凡王振元
Owner SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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