Unlock instant, AI-driven research and patent intelligence for your innovation.
Ramelteon sustained release preparation and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for ramelteon and sustained-release preparations, applied in the field of ramelteon sustained-release preparations and its preparation, can solve the problems of affecting the mental state of patients, short drug effect maintenance time, and reducing sleep quality
Active Publication Date: 2021-08-20
广东科泰鼎润药业科技有限公司
View PDF6 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] However, the traditional ramelteondrug releases rapidly and can make patients fall asleep in a short period of time, but at the same time, the duration of the drug effect is short, and patients are prone to wake up prematurely, and cannot fall asleep again after waking up, reducing the Sleep quality, which seriously affects the patient's mental state
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0067] The present invention also provides a method of preparing the above-mentioned thundermide sustained release formulation, including the following steps:
[0068] The thundermine, the filler is mixed with the sustained release material, then the lubricant is added, mixed.
[0069] In a specific example, the mixing also includes the following steps: a wet method of wet method using ethanol or water.
[0070] In a specific example, it is pressed after mixing.
[0071] In a specific example, filling the capsule after mixing.
[0072] In a specific example, the mixed filling bag is made into granules.
Embodiment 1
[0075] This embodiment provides a thundermine buffer preparation, and the specific prescription is as follows:
[0076]
[0077] The specific preparation method is as follows:
[0078] Mix the thundermine, lactose, microcrystalline pH101, hydroxypropylene Klucel Exf Pharm, silica mixed. A 95% ethanol solution was slowly added to the above mixed materials, while stirring while adding. The soft material made of manufactured is soft and suitable, and the group is touched. The soft material is grainted through 10 mesh screen, and the formed particles are placed at 60 ° C oven drying. After 1 hour of drying, the dry weight of the particles was measured, and the dry weight was stopped at <3%. The dried particles were further mixed with magnesiumstearate. The tablets, the slice weight is 250mg, the hardness is 3 to 10 kg.
Embodiment 2
[0080] This embodiment provides a thundermine buffer preparation, and the specific prescription is as follows:
[0081]
[0082] The specific preparation method is as follows:
[0083] Thundermine, lactose, microcrystalline pH 102, hydroxypropylmethylcellulose K4M, and silica are mixed uniform. The addition of magnesiumstearate is mixed. The tablets, the slice weight is 250mg, the hardness is 3 to 10 kg.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
hardness
aaaaa
aaaaa
Login to View More
Abstract
The invention provides a Ramelteon sustained release preparation. The dosage form of the Ramelteon sustained release preparation is a tablet, a granule or a capsule. The Ramelteon sustained-release preparation comprises the following raw materials in parts by weight: 1 to 30 parts of Ramelteon, 50 to 250 parts of a filling agent, 5 to 50 parts of a sustained-release material and 0.2 to 10 parts of a lubricating agent; the sustained-release material is selected from at least one of hydroxypropyl methylcellulose, polyvinylpyrrolidone, hydroxypropyl cellulose, sodium alginate, calcium alginate, guar gum and xanthan gum; and the filling agent is selected from at least one of lactose, mannitol, sorbitol, canesugar, microcrystallinecellulose and calcium hydrophosphate. The Ramelteon sustained release preparation can maintain enough drug concentration in a long time, prolongs the drug action time, and is completely dissolved out.
Description
Technical field [0001] The present invention relates to the pharmaceutical field, particularly to a sustained-release preparation Ramelteon its preparation method. Background technique [0002] Ramelteon, the chemical name (S) -N- [2- (1,6,7,8- tetrahydro -2H- indeno - [5,4-b] furan-8-yl) ethyl] propanamide, Ramelteon is the English name, molecular formula of C 16 Hide 21 NO 2 A molecular weight of 259.34, the following chemical structure: [0003] [0004] Ramelteon is Takeda Pharmaceuticals development of a medicament for treating insomnia, the first used in clinical treatment of insomniamelatoninreceptoragonist, able to selectively activate melatonin 2 receptor and receptor, but not with the 3 melatonin receptor having a potent and highly selective characteristics. Further, Ramelteon not bind to GABA receptors neurotransmitter receptors, within a certain range does not interfere with the activity of most enzymes, therefore, to avoid medication associated with GABA distrac...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
