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A kind of traditional Chinese medicine for treating rheumatoid arthritis

A rheumatoid and arthritis technology, applied in the field of traditional Chinese medicine for the treatment of rheumatoid arthritis, can solve the problems of limited drug efficacy, unbearable cost, and non-curative indicators, etc., achieve longer-lasting therapeutic effects, lower preparation costs, and lower usage cost effect

Active Publication Date: 2022-02-22
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The problems of the first type of means are: first, the acquisition of active ingredients of traditional Chinese medicine relies on complex separation and preparation techniques such as preparation chromatography, and the cost is very high. For patients with rheumatoid arthritis who need to take medicine for a long time, the cost is unbearable; second, Similar to western medicine, the active ingredient is single and the efficacy is limited
The problems of the second type of means are: 1. The compound ingredients of traditional Chinese medicine are complicated, and in most cases, they all have toxic ingredients. Side effects, and with the development of the disease, the dose and prescription need to be adjusted in real time. This strategy relies on the superb consultation skills and rich experience of traditional Chinese medicine. However, the current reality is that compared with the massive number of patients, the number of experienced old Chinese medicine Too little; Second, the experience of oral Chinese medicine is not good, and for rheumatoid arthritis, a chronic disease, it usually needs to be taken for a long time, and it is often difficult for patients to persist
The third type of problem is that the index does not cure the root cause, and it is difficult to effectively control the development of the disease
[0005] In general, traditional Chinese medicine has not reached its full potential in the treatment of rheumatoid arthritis, and there is a lack of well-experienced medication methods

Method used

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  • A kind of traditional Chinese medicine for treating rheumatoid arthritis
  • A kind of traditional Chinese medicine for treating rheumatoid arthritis
  • A kind of traditional Chinese medicine for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1: the preparation of Chinese medicine

[0067] 1. Take the same amount of Ephedra, Fangfeng, Chuanwu, Asarum, Fenfangji, Diwu, Tripterygium wilfordii, Sophora flavescens, Coix seed, Artemisia annua, Comfrey, Myrrh, Chuanxiong, Frankincense, Qingfengteng, Shenjincao , turmeric, ginseng, Codonopsis pilosula and Araceae medicinal materials are mixed, boiled twice, and the extracts are combined.

[0068] 2. The combined extract was separated by preparative chromatography, and the extract was divided into 20 components. The chromatographic conditions are as follows: Innovative Tongheng DAC100 chromatograph, see the chromatographic separation diagram figure 1 , the preparative chromatographic column is a reverse phase C18 column (100×250mm, 10 μm, Acchrom), mobile phase: A-MeOH, B-0.1%FA / H 2 O, gradient elution conditions: 0-50-80min, 35%-95%-95%A. The flow rate is 320mL / min, and the detection wavelength is 254nm.

[0069] 3. Dry the separated and prepared 20 ...

Embodiment 2

[0108] Embodiment 2: health care insole and health care socks for the treatment of rheumatoid arthritis

[0109] Such as Figure 13 As shown, the present invention provides a kind of health care insole and the matching health care socks 5, wherein the health care insole includes a shoe insole main body 1 and a gel medicine slow-release tablet 2-4 detachably installed on the insole main body, and the gel The drug slow-release tablets 2-4 are in close contact with the main body 1 of the foot and the insole.

[0110] The sole of the health socks 5 is provided with a hollow structure 6-7, and its position corresponds to the gel drug slow-release tablet 2-3. When a person puts on the health care socks 5 and steps on the health care insole, the skin of the human foot directly contacts the drug sustained release tablet 2-3 through the hollow structure 6-7, so that the medicine or health care products in the gel drug sustained release tablet can pass through The skin is released int...

Embodiment 3

[0113] Embodiment 3: the preparation of chitosan / carboxymethyl chitosan drug sustained-release tablet

[0114] The present embodiment provides a kind of preparation method of chitosan / carboxymethyl chitosan medicine slow-release tablet, specifically as follows:

[0115] At a certain temperature, a certain amount of chitosan is dissolved in 2% acetic acid solution by volume to prepare a chitosan-acetic acid solution. Accurately weigh a certain amount of GST into the chitosan-acetic acid solution and stir at 50°C for 5min. Under magnetic stirring, add 2.5mL of liquid paraffin and emulsify for a period of time. Add a certain amount of Span80, and slowly drop a certain mass fraction of sodium tripolyphosphate solution 2.5mL at a rate of 0.2mL / min, and react for a period of time. Add carboxymethyl chitosan aqueous solution containing a certain quality drop by drop, continue to stir and react for a period of time, centrifuge, freeze-dry and save the sample.

[0116] Chitosan / carb...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine, which is composed of high-efficiency and low-toxicity components separated from the total extract of the following Chinese medicinal materials in parts by weight: 1 part of Ephedra, 1 part of Fangfeng, 1 part of Aconitum Aconiti, 1 part of Asarum, 1-3 parts of Fangji, 1-3 parts of Diwu, 1 part of Tripterygium wilfordii, 1 part of Sophora flavescens, 1-3 parts of coix seed, 1-3 parts of Artemisia annua, 1 part of comfrey, 1 part of myrrh, 1 part of Chuanxiong ‑3 parts, 1 part of frankincense, 1 part of Qingfeng vine, 1‑3 parts of genus chinensis, 1‑3 parts of turmeric, 1‑3 parts of ginseng, 1‑3 parts of codonopsis, and 1 part of araceae. The invention also discloses the application of the traditional Chinese medicine in preparing medicine for treating rheumatoid arthritis and a health-care insole for treating rheumatoid arthritis. Compared with the total extract, the traditional Chinese medicine of the present invention has better drug efficacy, non-toxicity, less dose, and easy quality control, and compared with pure compounds, it can maintain the advantages of multiple targets, and the preparation cost is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease with synovitis as the main pathological change, involving multiple joints and accompanied by persistent pain. Later in the disease course can lead to cartilage destruction, bone erosion, joint deformity, and loss of function. RA is a complex chronic disease, the pathology has not yet been fully clarified, and it is very difficult to cure. In practice, it mainly relies on drugs or physical therapy to control the disease and improve the quality of life. [0003] Traditional Chinese medicine is currently an important means of treating rheumatoid arthritis, which can generally be divided into three categories: one is to use the active ingredients of traditional Chinese medicine such as tripterygium glycosides and tot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/70A61P19/02A61P37/02A43B17/00
CPCA61K36/17A61K36/238A61K36/714A61K36/268A61K36/59A61K36/71A61K36/37A61K36/489A61K36/8994A61K36/282A61K36/30A61K36/328A61K36/236A61K36/324A61K36/185A61K36/12A61K36/9066A61K36/258A61K36/344A61K36/8884A61K9/70A43B17/00A61P19/02A61P37/02A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 张秀莉罗勇韩夏荷
Owner SUZHOU UNIV
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