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Ca-AKG effervescent tablet and preparation method thereof

A technology of effervescent tablets and raw materials, applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, etc. Issues such as preparation prescription and preparation method

Inactive Publication Date: 2021-08-27
ABA CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this document does not further disclose the specific preparation prescription and preparation method for preparing the α-ketoglutarate calcium salt composition

Method used

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  • Ca-AKG effervescent tablet and preparation method thereof
  • Ca-AKG effervescent tablet and preparation method thereof
  • Ca-AKG effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] The preparation of embodiment 1 Ca-AKG effervescent tablet

[0105] Preparation prescription: 378 parts of calcium α-ketoglutarate, 315 parts of sodium bicarbonate, 180 parts of mannitol, 315 parts of citric acid, 9 parts of orange essence, 18 parts of aspartame, 13 parts of silicon dioxide, polyethylene glycol 600040 parts of diol, 1.3 parts of sunset yellow pigment, and 90 parts of povidone K30 aqueous solution with a mass percentage of 10%.

[0106] Preparation Process:

[0107] (1) wet granulation

[0108] Granule 1 preparation: put the prescribed amount of Ca-AKG and sodium bicarbonate in a wet mixing granulator, turn on low-speed mixing and chopping for 3 minutes, after mixing, turn on high-speed mixing and chopping, add binder, Mix for 3-5 minutes to make wet granules one;

[0109] Preparation of Granule 2: Put the prescribed amount of mannitol and citric acid in a wet mixing granulator, start mixing and chopping at low speed for 3 minutes, after mixing, turn ...

Embodiment 2

[0120] The preparation of embodiment 2 Ca-AKG effervescent tablet

[0121] Preparation prescription: 378 parts of calcium α-ketoglutarate, 385 parts of sodium bicarbonate, 220 parts of mannitol, 385 parts of citric acid, 11 parts of orange essence, 22 parts of aspartame, 17 parts of silicon dioxide, polyethylene glycol 600050 parts of diol, 1.7 parts of sunset yellow pigment, and 110 parts of povidone K30 aqueous solution with a mass percentage of 10%.

[0122] Preparation Process:

[0123] (1) wet granulation

[0124] Granule 1 preparation: put the prescribed amount of Ca-AKG and sodium bicarbonate in a wet mixing granulator, turn on low-speed mixing and chopping for 3 minutes, after mixing, turn on high-speed mixing and chopping, add binder, Mix for 3-5 minutes to make wet granules one;

[0125]Preparation of Granule 2: Put the prescribed amount of mannitol and citric acid in a wet mixing granulator, start mixing and chopping at low speed for 3 minutes, after mixing, turn...

Embodiment 3

[0136] The preparation of embodiment 3 Ca-AKG effervescent tablet

[0137] Preparation prescription: 378 parts of calcium α-ketoglutarate, 350 parts of sodium bicarbonate, 200 parts of mannitol, 350 parts of citric acid, 10 parts of orange essence, 20 parts of aspartame, 15 parts of silicon dioxide, polyethylene glycol 600045 parts of diol, 1.5 parts of sunset yellow pigment, and 96 parts of povidone K30 aqueous solution of 10% by mass.

[0138] Preparation Process:

[0139] (1) wet granulation

[0140] Granule 1 preparation: put the prescribed amount of Ca-AKG and sodium bicarbonate in a wet mixing granulator, turn on low-speed mixing and chopping for 3 minutes, after mixing, turn on high-speed mixing and chopping, add binder, Mix for 3-5 minutes to make wet granules one;

[0141] Preparation of Granule 2: Put the prescribed amount of mannitol and citric acid in a wet mixing granulator, start mixing and chopping at low speed for 3 minutes, after mixing, turn on high-speed ...

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Abstract

The invention relates to a Ca-AKG effervescent tablet. TheCa-AKG effervescent tablet is prepared by taking alpha-ketoglutarate as a raw material medicine and sodium bicarbonate, mannitol, citric acid, orange essence, aspartame, silicon dioxide, polyethylene glycol 6000, sunset yellow pigment and an adhesive as auxiliary materials. The invention further relates to a preparation method of the Ca-AKG effervescent tablet. The preparation method comprises the steps of wet granulation, drying, size stabilization, total mixing, tabletting, packaging and the like. The Ca-AKG effervescent tablet is stable in property and suitable for clinical application, the preparation method is easy and convenient to operate and good in reproducibility, and the prepared product is uniform in quality.

Description

technical field [0001] The present invention relates to a pharmaceutical preparation characterized by a special physical shape, in particular to an effervescent tablet preparation. Background technique [0002] In recent years, a large number of studies have found that α-ketoglutaric acid (Alpha-Ketoglutaric Acid, AKG) is an important intermediate product of muscle metabolism. During muscle exercise, both the tricarboxylic acid cycle and the deamination of glutamate can produce a large amount of AKG. Studies have shown that AKG plays an important regulatory role in protein synthesis, skeletal muscle development and metabolism, and calcium homeostasis. AKG can regulate muscle and bone development, cell metabolism, immune inflammation, and stem cell development through complex signaling pathways. These developments have important reference value for the application of AKG. [0003] Calcium α-ketoglutarate (Ca-AKG) is an important source of α-ketoglutarate anion. The α-ketog...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/194A61K47/10A61K47/12A61P19/08A61P21/00A61P29/00A61P37/02A61P43/00
CPCA61K9/0007A61K31/194A61K9/2013A61K9/2018A61P21/00A61P19/08A61P37/02A61P29/00A61P43/00
Inventor 张发成曹瑞山万竹青吴保祥韩凯
Owner ABA CHEM CORP
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