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31 results about "Bicarbonates sodium" patented technology

Metronidazole effervescence patch and technique of preparing the same

The invention discloses a Metronidazole, Clotrimazole and Chlorhexidine Acetate Effervescent Tablet and the preparation method. Each tablet has the following proportion of contents: metronidazole 0.2 gram, clotrimazole 0.16 gram, acetic acid chlorhexidine acetate 0.008 gram, fumaric acid 0.108 to 0.162 gram, tartaric acid 0.012 to 0.018 gram, solium bicarbonate 0.12 to 0.18 gram, starch 0.02 to 0.04 gram, dextrin 0.003 to 0.007 gram, hydroxypropyl cellulose 0.007 to 0.013 gram, talc 0.01 to 0.017 gram, sodium dodecyl sulfate 0.01to 0.02 gram, and proper proportion of povidone K30 water solution. According to the preparation method, the components are mixed to produce granule (1) and granule (2); the talc, sodium dodecyl sulfate and the granule (1) and granule (2) are mixed uniformly; granule content is tested and according to the granule content, the tablet weight is identified for tabletting. The invention overcomes the shortages with prior art, enables the acetic acid chlorhexidine acetate to perform functions normally, performs synergistic effects of the three drugs, and greatly enhances the cure rate. Besides, the frothing volume is high, and within storage period, the quality is stable and the drug effects are not affected.
Owner:SHANDONG SBOND PHARMA

Asymmetric syntheses method of (-)-sodium danshensu and application thereof

The invention discloses an asymmetric syntheses method of (-)-sodium danshensu and an application thereof, which belongs to the medicine chemical field. The method comprises the following steps: A)taking levodopa shown in a formula I as a raw material, and performing a hydroxyl acetylation to obtain S-3-(3,4-acetylphenyl)-2-alanine hydrochloride; B)performing a diazotization reaction on S-3-(3,4-acetylphenyl)-2-alanine hydrochloride obtained in the step A) to obtain S-3-(3,4-acetylphenyl)-2-hydracrylicacid in a formula III; C)performing hydrolysis on the S-3-(3,4-acetylphenyl)-2-hydracrylicacid in the step B to obtain S-3-(3,4-dihydroxy phenyl)-2-hydracrylicacid shown in a formula IV; and D)dropping a sodium bicarbonate saturated solution in the S-3-(3,4-dihydroxy phenyl)-2-hydracrylicacid to react to obtain sodium salt (-)-sodium danshensu shown in a formula V. The method has the advantages of easily available raw material and simple operation, and the (-)-sodium danshensu has good effect for treating myocardial ischemia and myocardial infarction.
Owner:HEBEI YILING MEDICINE INST

Operation rinsing water solution as well as preparation method and application thereof

The invention relates to an operation rinsing water solution as well as a preparation method and application thereof. The rinsing water solution is prepared from sodium chloride, sodium gluconate, sodium acetate, potassium chloride, magnesium chloride, L-lysine, sodium tartrate, sodium citrate, glycerol, sodium bicarbonate and potassium bicarbonate. The operation rinsing water solution of which the sodium ion concentration, potassium ion concentration, Na<+1> / Cl<-1>, osmotic pressure and pH value are in specific ranges is prepared by specifically selecting specific ingredients properly determining usage and regulating pH value, and when the conditions are met at the same time, the operation rinsing water solution is safe and non-toxic, has excellent stability, and has tremendous application value and industrial production potential in medical field and clinical application.
Owner:ZHEJIANG TIANRUI PHARMA

Glutathione reductase detection kit as well as preparation method and application thereof

The invention provides a glutathione reductase detection kit and a preparation method and application thereof. The kit comprises a reagent R1 and a reagent R2, wherein the reagent R1 comprises a potassium phosphate buffer solution, EDTA, GSSG, ascorbic acid oxidase, bilirubin oxidase, potassium ferricyanide, a surfactant, a first bacteriostatic agent and a second bacteriostatic agent; and the reagent R2 comprises a sodium bicarbonate buffer solution, NADPH, the first bacteriostatic agent, a surfactant and a stabilizer. Compared with the prior art, the glutathione reductase detection kit provided by the invention has the advantages of good airborne stability, high sensitivity and strong antibacterial ability, and can meet requirements of clinical application of glutathione reductase detection.
Owner:NINGBO MEDICAL SYSTEM BIOTECHNOLOGY CO LTD

Preparation method of low-odor foamed polypropylene material

The invention relates to a preparation method of a low-odor foamed polypropylene material, and the method comprises the following steps of: weighing polypropylene resin, a sodium borohydride alcohol solution and auxiliary materials, and mixing for at least 1h under the condition that the temperature is not lower than 100 DEG C; then melting, extruding, cooling and setting; after that, mixing withsodium bicarbonate and performing injection molded. The method introduces a sodium borohydride cyclohexanol solution; sodium borohydride can reduce formaldehyde to methanol, cyclohexanol can dissolveformaldehyde and other harmful organic substances and bring them out when vaporized; therefore, the content of the formaldehyde and other harmful organic substances in the material can be effectivelyreduced, the pungent smell of the material and the amount of the harmful substances the can be volatilized are reduced, and the environmental protection of the polypropylene material is improved; at the same time, the mechanical properties test results show that the introduction of the sodium borohydride cyclohexanol solution has no effect on the overall mechanical properties of the material.
Owner:SUZHOU RUNJIA ENGINEER PLASTIC

Cefoperazone sodium tazobactam sodium medicine composition for injection and preparing process of cefoperazone sodium tazobactam sodium medicine composition

The invention relates to the field of medicine preparations, and in particular to a cefoperazone sodium tazobactam sodium medicine composition for injection and a preparing process of the cefoperazone sodium tazobactam sodium medicine composition. The cefoperazone sodium tazobactam sodium medicine composition for injection comprises cefoperazone, tazobactam and sodium bicarbonate, and the weight ratio of the cefoperazone to the tazobactam to the sodium bicarbonate is 8:2:1.52-1.68. By means of the medicine composition, the clinic safety performance is improved, and risks of anaphylactic reactions are reduced; and meanwhile the product quality is guaranteed. The invention further provides the preparing process of the medicine composition. The process is simple, the cost is saved, the mixing uniformity of the medicine composition can be effectively improved, generation of polymer in the preparing process is effectively reduced, the polymer and other impurities generated by the high temperature in the split packaging process are prevented, and meanwhile oxidation of active ingredients in the preparing process is reduced.
Owner:JINAN KANGHE MEDICAL TECH

Composition of sodium ozagrel and polyethylene glycol and preparation method thereof

The invention discloses a composition of sodium ozagrel and polyethylene glycol and a preparation method thereof, belonging to the medical technical field. The weight ratio of sodium ozagrel to polyethylene glycol in the pharmaceutical composition is 1:0.002-0.1. Injections can be prepared by using the pharmaceutical composition and auxiliary material which is acceptable in pharmacy and the auxiliary material is selected from one or more of lactose, mannitol, sorbitol, dextran, citric acid-sodium citrate and sodium bicarbonate-sodium carbonate. The pharmaceutical composition is used to cure dyskinesia associated with acute thrombotic infarction and cerebral infarction.
Owner:BEIJING SIHUAN PHARMA +1

Meloxicam-Containing Granulated Product

To provide a technique for improving the dissolution of meloxicam. A granulated product, including the following components (A), (B), and (C): (A) meloxicam or a salt thereof, or a solvate thereof; (B) one or more basic compounds selected from the group consisting of potassium bicarbonate, sodium bicarbonate, arginine, lysine, magnesium hydroxide, and magnesium oxide; and (C) a water-swellable polymer.
Owner:SS PHARMA CO LTD

Compressed capsules for giving birth to males

The present invention is related to baby love male capsules including active ingredients such as fludrocortisone, bumetanide, sodium bicarbonates, sodium chloride, and Licourice extract, inactive ingredients such as gelatin, plasticizers, moisture absorbents, and preservatives.The active ingredients are selected according to ovum wall thickness and cell fragility theories. The present invention leads to a breakthrough in the medical field through which the baby gender can be determined and many chronic diseases can be cured.
Owner:RASHWAN EMAD ABD ELAZEEM

Peritoneal dialysis solution with high de-watering rate

The invention discloses a peritoneal dialysis solution with high de-watering rate and solves the de-watering problem of the dialysis solution. The peritoneal dialysis solution comprises 10-15 percentby W / V of sodium chloride, 0.2-5 percent by W / V of calcium chloride, 2-5 percent by W / V of potassium chloride, 2-5 percent by W / V of sodium bicarbonate, 2-5 percent by W / V of magnesium chloride, 2-10percent by W / V of monascus polysaccharide and 0-5 percent by W / V of maltose.
Owner:宋宏婷

Process for synthesis of sodium glycididazole

This invention belongs to medicine chemical technology field. This invention discloses a new synthesis technique of dry ammonia double azole natrium. The material is nitrilotriacetic acid, then it reacts with acetic anhydride in N, N-dimethyl amide, and product is got after refining and salifying with bicarbonates. The reaction yield is high, cost is low of this technique, labor intensity is reduced, and it is convenient to scale producing and environment protection.
Owner:SHANDONG LUYE PHARMA CO LTD

Novel application of sodium bicarbonate in prevention and treatment of human coronavirus infection

The invention relates to a novel application of sodium bicarbonate in prevention and treatment of human coronavirus infection. A sterilized aqueous solution is prepared from the sodium bicarbonate by using a conventional process and is used for preparing a spray which is sprayed into the mouth, nose and throat and is inhaled into the lung with breathing, an aerosol and an injection; the upper respiratory tract, including the oral cavity, is sprayed, the lower respiratory tract is administrated by atomization, the viral envelop lipidosome is broken by lipolysis, the coronavirus envelop is broken to inactivate the virus and destroy and block the viral envelop to combine with a receptor, so that the coronavirusis inactivated by losing the recognition and adsorption capacity of host cells. The application is used for controlling and treating coronavirus infection.
Owner:北京中卫神农慢性病医学研究院有限公司

A kind of terbinafine hydrochloride effervescent tablet and using method thereof

The invention discloses a terbinafine hydrochloride effervescent tablet, comprising 120-150 parts of terbinafine hydrochloride, 160-190 parts of citric acid, 160-190 parts of sodium bicarbonate, and 20-35 parts of sodium starch glycolate and 15-20 parts of low-substituted hydroxypropyl cellulose, the auxiliary materials include by weight: 285-315 parts of lactose, 20-30 parts of polysorbate 80, 35-55 parts of povidone K30, 70-90 parts of dehydrated alcohol parts and 8-12 parts magnesium stearate. In the present invention, by adding citric acid and sodium bicarbonate, the dissolution of the terbinafine hydrochloride effervescent tablet during use is accelerated. Method, use warm water to accelerate the dissolution of the product in water, stir evenly, and then soak the feet or hands containing the lesions in the liquid medicine. This method of use is targeted and prevents the loss of the medicine. The dosage can be adjusted according to the severity of the lesions, and the effect is fast. , high safety, small side effects, significant curative effect, short treatment time, and a wide range of applicable objects.
Owner:上海桓华制药有限公司

Biological buffering bicarbonate tablet and preparation method thereof

The invention relates to a biological buffering bicarbonate tablet and a preparation method thereof. The preparation method comprises the following steps: (1) accurately weighing sodium carbonate, sodium bicarbonate, cross-linked amylose and sodium azide; (2) uniformly mixing the above components under stirring; (3) pressing the components into a tablet on a tablet press; and (4) carrying out weighing and testing to obtain qualified tablets, and then carrying out packaging; wherein the pressure of the tablet press is five tons. The round tablet prepared in the invention can be directly used immediately after opening of package, is simple to use, substantially mitigates labor intensity of users, saves working time and improves working efficiency; in usage, the tablet can be rapidly dissolved after addition into a solvent with a fixed volume, so a desired buffer solution with an accurate and stable pH value can be obtained; and the tablet is easy to preserve and transport, long in preservation time, simple and rapid to prepare and suitable for industrial processing.
Owner:TIANJIN GUANGFU TECH DEV

Antibacterial environment-friendly tableware and preparation method thereof

The invention discloses antibacterial environment-friendly tableware and a preparation method thereof. The preparation method comprises the following steps: weighing the following raw materials: polylactic acid, Arabic gum, sodium bicarbonate, polyvinyl alcohol, poly-3-hydroxybutyrate, calcium stearate, a coupling agent, an inorganic filler, an antibacterial agent and water; mixing and stirring the raw materials to obtain mixed slurry; injecting the mixed slurry into a mold for hot pressing, and demolding after molding; and taking out the demolded finished product, drying, trimming, deburring, and disinfecting to obtain the finished product. The antibacterial environment-friendly tableware disclosed by the invention has good mechanical property, antibacterial property and degradation property.
Owner:宁夏青林华源科技有限公司

Ca-AKG effervescent tablet and preparation method thereof

The invention relates to a Ca-AKG effervescent tablet. TheCa-AKG effervescent tablet is prepared by taking alpha-ketoglutarate as a raw material medicine and sodium bicarbonate, mannitol, citric acid, orange essence, aspartame, silicon dioxide, polyethylene glycol 6000, sunset yellow pigment and an adhesive as auxiliary materials. The invention further relates to a preparation method of the Ca-AKG effervescent tablet. The preparation method comprises the steps of wet granulation, drying, size stabilization, total mixing, tabletting, packaging and the like. The Ca-AKG effervescent tablet is stable in property and suitable for clinical application, the preparation method is easy and convenient to operate and good in reproducibility, and the prepared product is uniform in quality.
Owner:ABA CHEM CORP +1

Composite effervescent tablet as well as preparation method and application thereof in gargling

The invention discloses a composite effervescent tablet which comprises tinidazole, chlorhexidine acetate, sodium fluoride, cyclodextrin, a filler, organic acid, sodium bicarbonate and / or sodium carbonate and a lubricant. The invention further discloses a preparation method of the compound effervescent tablet and application of the compound effervescent tablet in gargling. The composite effervescent tablet containing tinidazole and chlorhexidine acetate is high in dissolution speed, high in solution clarity, convenient to carry and long-acting in quality guarantee, not only has the effects of cleaning, diminishing inflammation and resisting bacteria, but also has the effects of preventing decayed teeth and strengthening teeth, and is wide in application prospect.
Owner:SHANGHAI CHANGZHENG HOSPITAL +1

A kind of edaravone sodium chloride injection and preparation method thereof

The invention relates to an edaravone sodium chloride injection and a preparation method thereof. 100ml of the injection includes: edaravone 20-40mg, sodium chloride 0.6-1.0g, propylene glycol 100-150mg, vitamin C 2.5-3.5g, sodium bicarbonate 0.3-1.0g, pH adjusted to 3.5-5.0. The preparation process of the injection comprises: dosing, filtering, filling, capping, sterilizing, and lamp inspection; the dosing adopts a two-step preparation method, and the preparation process adopts low-temperature preparation. The method is simple to operate and low in cost, and the prepared Edaravone Sodium Chloride Injection has good drug stability, less side effects, effectively reduces the production of impurities, and has high drug compliance and safety for patients. It is used to improve acute cerebral palsy Neurological symptoms, activities of daily living and dysfunction caused by infarction can effectively prevent and treat brain injury.
Owner:JINAN KANGHE MEDICAL TECH

Pharmaceutical preparation of cefotaxime sodium compound and preparation method thereof

The invention discloses a pharmaceutical preparation of a cefotaxime sodium compound. The pharmaceutical preparation comprises the following raw materials: 10 parts of cefotaxime sodium; 57.86 parts of N-(beta-D-glucopyranose) octanamide, and 57.86 parts of N-(beta 19.29 parts of octadecylamine; 162.14 parts of 1-palmitoyl-2-stearoyl lecithin, and 162.14 parts of 1-palmitoyl-2 27.14 parts of mannitol; 80.71 parts of cholesterol; 62.86 parts of tartaric acid; and 15.71 parts of solid sodium bicarbonate particles. In addition, the invention also discloses a preparation method of the medicinal preparation. The cefminox sodium pharmaceutical preparation is better in flowability; meanwhile, after long-time storage (for example, more than three months), the drug encapsulation efficiency is basically kept unchanged.
Owner:上海欣峰制药有限公司

Polystyrene seed emulsion and preparation method thereof

The invention relates to a polystyrene seed emulsion, which is prepared from the following raw materials in parts by weight: 500-600 parts of a styrene monomer, 4-10 parts of t-DDM, 0.5-1 part of sodium bicarbonate, 200-220 parts of Disponil SLS103, 1-2 parts of potassium persulfate and 1200-1300 parts of water. The invention also provides a preparation method of the polystyrene seed emulsion. The operation steps are simple, the raw materials are easy to obtain, the cost is low, and the polystyrene seed emulsion with high monomer conversion rate and small particle size can be obtained through the method. It is found that the time for adding an initiator into an emulsion system plays an important role in monomer conversion rate and particle size distribution.
Owner:广东天银实业有限公司
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