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A kind of terbinafine hydrochloride effervescent tablet and using method thereof

A technology of soaking terbinafine hydrochloride and nafine, which is applied in the field of medicine, can solve the problems of long treatment time, adverse reactions, and reduced drug efficacy, and achieve the effects of wide range of applicable objects, prevention of drug loss, and short treatment time

Active Publication Date: 2022-07-22
上海桓华制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But when it is used in practice, at present, the treatment of tinea pedis and onychomycosis with terbinafine hydrochloride all adopts the oral mode, and oral terbinafine hydrochloride may have adverse reactions, which is harmful to the body. , it cannot be used, and it is not targeted, the onset is slow, the efficacy of the drug reaches the lesion, the treatment time is long, the drug cannot be used according to the severity of the lesion, and the safety is not high

Method used

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  • A kind of terbinafine hydrochloride effervescent tablet and using method thereof

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Effect test

Embodiment 1

[0024] The invention provides a terbinafine hydrochloride effervescent tablet, wherein the main materials used include by weight: 120 parts of terbinafine hydrochloride, 160 parts of citric acid, 160 parts of sodium bicarbonate, sodium starch glycolate 20 parts and 15 parts of low-substituted hydroxypropyl cellulose, the auxiliary materials include by weight: 285 parts of lactose, 20 parts of polysorbate 80, 35 parts of povidone K30, 70 parts of anhydrous ethanol and 8 parts of magnesium stearate ;

[0025] Also includes the preparation method of terbinafine hydrochloride effervescent tablet, the specific operation steps are:

[0026] Step 1: raw material pretreatment, terbinafine hydrochloride, citric acid, sodium bicarbonate, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose and lactose are respectively dried, and then passed through a 100-mesh sieve respectively, according to the recipe quantity Weigh the spare;

[0027] Step 2: prepare a mixed solution...

Embodiment 2

[0037] The invention provides a terbinafine hydrochloride effervescent tablet, wherein the main materials used include by weight: 141 parts of terbinafine hydrochloride, 180 parts of citric acid, 180 parts of sodium bicarbonate, sodium starch glycolate 27.5 parts and 18.8 parts of low-substituted hydroxypropyl cellulose, the auxiliary materials include by weight: 305 parts of lactose, 25 parts of polysorbate 80, 47 parts of povidone K30, 81 parts of absolute ethanol and 10 parts of magnesium stearate ;

[0038]Also includes the preparation method of terbinafine hydrochloride effervescent tablet, the specific operation steps are:

[0039] Step 1: pretreatment of raw materials, terbinafine hydrochloride, citric acid, sodium bicarbonate, sodium starch glycolate, low-substituted hydroxypropyl cellulose and lactose were respectively dried, and then passed through a 100-mesh sieve respectively, according to the recipe quantity Weigh the spare;

[0040] Step 2: prepare a mixed solu...

Embodiment 3

[0050] The invention provides a terbinafine hydrochloride effervescent tablet, wherein the main materials used include by weight: 150 parts of terbinafine hydrochloride, 190 parts of citric acid, 190 parts of sodium bicarbonate, sodium starch glycolate 35 parts and 20 parts of low-substituted hydroxypropyl cellulose, the auxiliary materials include by weight: 315 parts of lactose, 30 parts of polysorbate 80, 55 parts of povidone K30, 90 parts of anhydrous ethanol and 12 parts of magnesium stearate ;

[0051] Also includes the preparation method of terbinafine hydrochloride effervescent tablet, the specific operation steps are:

[0052] Step 1: pretreatment of raw materials, terbinafine hydrochloride, citric acid, sodium bicarbonate, sodium starch glycolate, low-substituted hydroxypropyl cellulose and lactose were respectively dried, and then passed through a 100-mesh sieve respectively, according to the recipe quantity Weigh the spare;

[0053] Step 2: prepare a mixed soluti...

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Abstract

The invention discloses a terbinafine hydrochloride effervescent tablet, comprising 120-150 parts of terbinafine hydrochloride, 160-190 parts of citric acid, 160-190 parts of sodium bicarbonate, and 20-35 parts of sodium starch glycolate and 15-20 parts of low-substituted hydroxypropyl cellulose, the auxiliary materials include by weight: 285-315 parts of lactose, 20-30 parts of polysorbate 80, 35-55 parts of povidone K30, 70-90 parts of dehydrated alcohol parts and 8-12 parts magnesium stearate. In the present invention, by adding citric acid and sodium bicarbonate, the dissolution of the terbinafine hydrochloride effervescent tablet during use is accelerated. Method, use warm water to accelerate the dissolution of the product in water, stir evenly, and then soak the feet or hands containing the lesions in the liquid medicine. This method of use is targeted and prevents the loss of the medicine. The dosage can be adjusted according to the severity of the lesions, and the effect is fast. , high safety, small side effects, significant curative effect, short treatment time, and a wide range of applicable objects.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a terbinafine hydrochloride effervescent tablet and a method for using the same. Background technique [0002] Tinea pedis (commonly known as athlete's foot) is caused by a fungal infection. The skin damage often occurs on one side (ie, one foot) first, and the opposite side is infected after several weeks or months. It is common between the three or four toes, and can also appear on the soles of the feet. It is a small deep blister that can gradually merge into a bulla. The skin lesions of tinea pedis have a characteristic, that is, the boundary is clear, and it can gradually expand outward. Onychomycosis, commonly known as "onychomycosis", refers to the disease caused by dermatophytes invading the nail plate or under the nails, and onychomycosis is caused by dermatophytes Nail infections caused by fungi such as , yeast and non-dermatophytes, terbinafine hydrochloride is an al...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/36A61K47/38A61K47/26A61K47/12A61K47/02A61K31/137A61P31/10A61P17/00
CPCA61K9/0014A61K9/0007A61K9/2059A61K9/2054A61K9/2031A61K9/2013A61K9/2009A61K31/137A61P31/10A61P17/00
Inventor 张文生韩峰肖娟
Owner 上海桓华制药有限公司
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