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Composite effervescent tablet as well as preparation method and application thereof in gargling

A technology of effervescent tablets and clathrates, which is applied in the fields of drug combination, oral cavity care, and pharmaceutical formulations. It can solve the problems of fast dissolution, high solution clarity, and inconvenient portability of mouthwash, etc., so that it is not easy to carry and improves solubility. , easy to carry effect

Pending Publication Date: 2022-07-26
SHANGHAI CHANGZHENG HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to solve the technical problem that the current mouthwash is inconvenient to carry, and provides a composite effervescent tablet containing tinidazole and chlorhexidine acetate. The drug of chlorhexidine acetate functions normally, and the dissolution rate is fast, and the solution clarity is high

Method used

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  • Composite effervescent tablet as well as preparation method and application thereof in gargling
  • Composite effervescent tablet as well as preparation method and application thereof in gargling
  • Composite effervescent tablet as well as preparation method and application thereof in gargling

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preparation example Construction

[0058] like figure 1 As shown, in one embodiment of the present invention, the preparation method of the composite effervescent tablet containing tinidazole and chlorhexidine acetate, comprises the following steps:

[0059] Weigh tinidazole or chlorhexidine acetate: hydroxypropyl-β-cyclodextrin in a molar ratio of 1:1-1:2, put it into a round-bottomed flask, add 10-20ml of 90% ethanol solution, and place it at 40 Stir at a constant temperature of 30-80rpm for 2-4h in a -60°C water bath, cool, remove unincorporated tinidazole or chlorhexidine acetate by high-speed centrifugation, evaporate the solvent, and place it in a vacuum drying box to dry for 8h-16h. Nitazole or chlorhexidine acetate inclusion complex powder, ground with a mortar and sieved;

[0060] Weigh sodium fluoride, filler, organic acid, sodium bicarbonate and / or sodium carbonate, lubricant in proportion, add tinidazole clathrate and chlorhexidine acetate clathrate, and mix to obtain mixed powder;

[0061] Under ...

Embodiment 1

[0067] The raw materials and their percentages (%) are as follows (the raw materials used are all medicinal specifications, and the reagents are of analytical grade):

[0068] Tinidazole 1.25, chlorhexidine acetate 1.25, hydroxypropyl-β-cyclodextrin 27.00, sodium fluoride 2.50, tartaric acid 29.00, sodium bicarbonate 33.00, PEG6000 1.00, lactose 5.00.

[0069] Weigh tinidazole and chlorhexidine acetate respectively according to the percentage content, add hydroxypropyl-β-cyclodextrin respectively, carry out inclusion operation by constant temperature stirring method, then dry, grind and sieve, then add sodium fluoride, Tartaric acid, sodium bicarbonate, lactose, and PEG6000 are mixed, the indoor temperature is lowered to below 20° C. and the humidity is lowered to below 35%, and direct tableting is performed.

[0070] The tableting process was smooth without sticking punching, splitting and other phenomena. The disintegration time of the prepared tablet was 1 minute and 42 sec...

Embodiment 2

[0072] The raw materials and their percentages (%) are as follows (the raw materials used are all medicinal specifications, and the reagents are of analytical grade):

[0073] Tinidazole 2.5, chlorhexidine acetate 2.5, methyl-β-cyclodextrin 13.00, sodium fluoride 5.00, citric acid 39.00, sodium carbonate 34.00, sodium lauryl sulfate 2.00, cellulose 2.00.

[0074] Weigh tinidazole and chlorhexidine acetate respectively according to the percentage content, add methyl-β-cyclodextrin and carry out inclusion operation by rotary evaporator, then dry, grind and sieve, then add sodium fluoride, lemon Acid, sodium carbonate, cellulose, and sodium lauryl sulfate are mixed, the indoor temperature is lowered to below 20° C. and the humidity is lowered to below 35%, and direct tableting is performed.

[0075] The tableting process was smooth without sticking punching, splitting and other phenomena. The disintegration time of the prepared tablet was 1 minute and 48 seconds, and the solution...

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Abstract

The invention discloses a composite effervescent tablet which comprises tinidazole, chlorhexidine acetate, sodium fluoride, cyclodextrin, a filler, organic acid, sodium bicarbonate and / or sodium carbonate and a lubricant. The invention further discloses a preparation method of the compound effervescent tablet and application of the compound effervescent tablet in gargling. The composite effervescent tablet containing tinidazole and chlorhexidine acetate is high in dissolution speed, high in solution clarity, convenient to carry and long-acting in quality guarantee, not only has the effects of cleaning, diminishing inflammation and resisting bacteria, but also has the effects of preventing decayed teeth and strengthening teeth, and is wide in application prospect.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a composite effervescent tablet comprising tinidazole and chlorhexidine acetate. In addition, the present invention also relates to the preparation method of the composite effervescent tablet and the use for gargling. Background technique [0002] Effervescent tablet is a new type of tablet that utilizes the reaction of organic acid and basic carbonate (bicarbonate) as a disintegrant, rapidly disintegrates in water, generates and releases a large amount of carbon dioxide gas. Very good application prospects. [0003] Tinidazole is a nitroimidazole drug. It is an anti-anaerobic and antigenic biological drug with higher efficacy, shorter course of treatment and better tolerance developed after metronidazole. It is widely used in anaerobic infection and can be quickly eliminated. Inflammation caused by oral anaerobic bacteria, relieve symptoms. [0004] Chlorh...

Claims

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Application Information

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IPC IPC(8): A61K33/16A61K9/46A61K47/10A61K47/12A61K47/02A61K47/69A61P1/02A61P31/04A61P31/02A61P29/00A61K8/49A61K8/43A61K8/21A61K8/73A61K8/86A61K8/365A61K8/19A61K8/02A61Q11/00A61K31/155A61K31/4164
CPCA61K33/16A61K31/155A61K31/4164A61K9/0007A61K9/2031A61K9/2013A61K9/2009A61K9/2095A61K47/6951A61P1/02A61P31/04A61P31/02A61P29/00A61K8/4946A61K8/43A61K8/21A61K8/738A61K8/86A61K8/365A61K8/19A61K8/0216A61Q11/00A61K2300/00Y02A50/30
Inventor 姜蕾鲁莹张翮卢光照张凤张鹰楠
Owner SHANGHAI CHANGZHENG HOSPITAL
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