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Allopurinol sustained-release capsule

A technology of sustained-release capsules and allopurinol, applied in the field of pharmacy, can solve problems such as poor stability, high viscosity of shellac, and poor roundness of pellets, and achieve small batch-to-batch differences, complete quality standards, and high-quality products. good stability effect

Active Publication Date: 2021-08-31
黑龙江澳利达奈德制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Allopurinol sustained-release capsules sold in the existing market have a relatively high viscosity of shellac, and the preparation of pellets has poor roundness and poor stability

Method used

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  • Allopurinol sustained-release capsule
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  • Allopurinol sustained-release capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment 1, monolayer drug application

[0065] Sustained release material: povidone K90+stearic acid

[0066]

[0067] Process:

[0068] 1. Material weighing: Weigh allopurinol, sucrose core, povidone K90, and stearic acid in prescribed dosage.

[0069] 2. Suspension preparation: Dissolve povidone K90 in 80% ethanol-water and stir well. Add stearic acid and allopurinol, stir evenly, then homogenize for 3 minutes, prepare solid content: 25%,

[0070] 3. Coating and applying medicine

[0071] Pour the ball core into the centrifugal coating machine, adjust the parameters, set the blast frequency: 30-45%, turn on the air inlet heating, set the inlet air temperature at 55-75°C, the host speed at 330-400rpm, and the atomization pressure at 0.06- 0.15Mpa, peristaltic pump speed: 20-35rpm, gradually spray the suspension liquid onto the rotating ball core in the pot, control the spray speed, air volume and air temperature, and keep the material dry and wet properly. A...

Embodiment 2

[0072] Embodiment 2, double-layer drug application

[0073]

[0074] Process:

[0075] 1. Material weighing: Weigh allopurinol, sucrose core, povidone K30, and stearic acid in prescribed dosage.

[0076] 2. Suspension solution preparation:

[0077] ①Inner liquid medicine: add povidone K30, raw material medicine, stearic acid (if any) into 80% medicinal ethanol solution, 80% ethanol, solid content: 25%, fully stir evenly, use a mixing homogenizer After homogenizing for 2-3 minutes, stir slightly mechanically for use.

[0078] ② Outer liquid medicine: Dissolve povidone K30, raw material medicine and stearic acid in 80% medicinal ethanol solution, solid content: 25%, stir well and homogenize with a mixing homogenizer for 2-3 minutes, Stir lightly mechanically and set aside.

[0079] 3. Coating and applying medicine

[0080] ① Turn on the operating equipment, set the inlet air temperature to 50-75°C, the blast air volume: 20-45%, and the host speed to 330rpm.

[0081] ②Do...

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Abstract

The invention belongs to the field of pharmacy, and relates to an allopurinol sustained-release capsule. The allopurinol sustained-release capsule is prepared by processing the following components: allopurinol, pill cores, povidone, stearic acid and talcum powder. The capsule disclosed by the invention has the characteristics of good dissolution rate, relatively high medicine applying efficiency and good stability.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a sustained-release capsule. Background technique [0002] Allopurinol, also known as allopurinol, is the first drug on the market to inhibit uric acid production and belongs to the xanthine oxidase inhibitor. Both the original drug and its metabolites can inhibit xanthine oxidase, so that hypoxanthine and xanthine cannot be converted into uric acid, and inhibit the synthesis of uric acid. [0003] Allopurinol is a white crystalline powder. Almost insoluble in water, ethanol or chloroform. Soluble in sodium hydroxide solution. [0004] Allopurinol mainly has the following medicinal functions: 1. Initiated and secondary hyperuricemia, especially hyperuricemia caused by excessive uric acid production. 2. Recurrent or chronic gout; 3. Uric acid nephrolithiasis and (or) uric acid nephropathy; 4. Hyperuricemia with renal insufficiency. [0005] Allopurinol and its metabolite oxypurinol reduc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/519A61K47/32A61K47/12A61K47/02A61P19/06
CPCA61K9/485A61K9/1676A61K9/1694A61K9/1635A61K9/1617A61K31/519A61P19/06Y02A50/30
Inventor 周有财
Owner 黑龙江澳利达奈德制药有限公司
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