Oral mucosa repair in-situ temperature-sensitive gel with antibacterial effect

Abstract

The invention relates to oral mucosa repair in-situ temperature-sensitive gel with an antibacterial effect and a preparation method thereof. The oral mucosa repair in-situ temperature-sensitive gel is prepared from the following raw materials in parts by mass of 25 to 55 parts of liquid grease, 1 to 8 parts of phytantriol, 25 to 45 parts of soybean phospholipid, 5 to 20 parts of polyphenol, 0.1 to 5 parts of Tween, 2 to 15 parts of organic solvent and 0.1 to 5 parts of peppermint oil. The preparation method of the oral mucosa repair in-situ temperature-sensitive gel comprises the following steps of i) putting soybean phospholipid into a closed container, adding the organic solvent, and shaking and dissolving at room temperature for later use; and ii) sequentially dissolving liquid grease, Tween, peppermint oil and polyphenol in the soybean phospholipid solution prepared in the step i) to prepare the yellow and clear in-situ temperature-sensitive gel. The in-situ gel does not contain a polymer temperature-sensitive material, is dropped or sprayed on the surface of an oral ulcer mucosa to quickly form a layer of closed cubic liquid crystal phase lipid membrane, has dilution resistance and mucosa adhesion, and can slowly release a polyphenol antibacterial agent to promote healing of the ulcer mucosa. The oral mucosa repair in-situ temperature-sensitive gel is simple to prepare and good in reproducibility, and large-scale production is easy to realize.

Description

Technical field [0001] The present invention is in the field of medical devices, particularly to the oral mucosa having an antibacterial effect in situ repair thermosensitive hydrogel. Background technique [0002] Refers to oral mucositis and ulcerative oral inflammatory reactions, release of several common complications of chemotherapy in cancer patients (e.g., vomiting, loss of appetite, allergic response, and the like), one of the clinical oral allodynia usually, particularly when the speaker after eating and other stimulation is more obvious, which greatly affect the patient's verbal communication, eating and sleeping properly, resulting in decreased quality of life, worse hinder its further treatment. Current treatments for such complications mostly rinse liquid preparations, powders, films, ointments and gels based. Gargle presence residence time is short, poor wound closing effect. Poor mucosal adhesion powders, easily diluted saliva, break up and away from ulcers, to ach...

AI Technical Summary

Problems solved by technology

Since the temperature-sensitive tooth adhesives are poloxamer, hydroxypropylmethylcellulose, and methylcellulose, the in-situ gel is not resistant to dilution with oral saliva, has poor film-forming ability, and has poor adhesion. Defects of weak ability and short oral residence time

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