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Hybrid single micelle nanoparticles for encapsulating functional molecules and preparation method of hybrid single micelle nanoparticles

A nanoparticle and single micelle technology, applied in the field of nanomaterials, achieves the effects of simple preparation, improved structural stability, and uniform size

Pending Publication Date: 2021-09-07
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Therefore, it remains a great challenge to design and synthesize more stable micellar carriers in order to improve the structural and functional stability of micelles and enhance the interaction between surfactants at the single micelle level.

Method used

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  • Hybrid single micelle nanoparticles for encapsulating functional molecules and preparation method of hybrid single micelle nanoparticles
  • Hybrid single micelle nanoparticles for encapsulating functional molecules and preparation method of hybrid single micelle nanoparticles
  • Hybrid single micelle nanoparticles for encapsulating functional molecules and preparation method of hybrid single micelle nanoparticles

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preparation example Construction

[0030] The preparation method of the hybrid single micellar nanoparticles for encapsulating functional molecules provided by the present invention, the specific steps are:

[0031] At room temperature, the block polymer Pluronic F127 and inorganic salts were stirred and dissolved in water to form a single micelle solution;

[0032] The functional molecules are introduced by dropping the functional molecules pre-dissolved in mesitylene into the single micellar solution formed in the previous step;

[0033] Adding silane to the above mixed solution to realize the hybridization of single micelles;

[0034] Purification of the hybrid single micelle nanoparticles was achieved by dialysis, and monodisperse, uniformly sized hybrid single micelle nanoparticles with encapsulated functional molecules were obtained.

[0035] In the present invention, the inorganic salt is preferably KCl or KF, and the amount used is 0.075mmol-0.225mmol. The present invention has no special requirements ...

Embodiment 1

[0045] Weigh 0.5g Pluronic F127, dissolve 0.15mmol KCl in 15ml water, stir and clarify, add 500μL mesitylene dropwise, continue stirring for 2 hours, then add tetramethoxysilane dropwise to the mixture, totaling 500μL, Reaction 2 hours, and then transfer the reaction solution into a dialysis bag with a molecular cut-off of 14,000, dialyze with deionized water as the dialysate, and dialyze for 24 hours to obtain hybrid single micellar nanoparticles. From figure 1 It can be seen that the present invention has successfully prepared hybrid single micellar nanoparticles with a particle diameter of about 25nm.

Embodiment 2

[0047] Weigh 0.5g of Pluronic F127, dissolve 0.15mmol KCl in 15ml of water, stir and clarify, add 500μL of mesitylene containing 0.1mg of ICG (ICG as a functional molecule, belonging to organic fluorescent probe) dropwise, continue to stir for 2 hours, then Add tetramethoxysilane dropwise to the mixed solution, totaling 500 μL, react for 2 hours, then transfer the reaction solution into a dialysis bag with a molecular cut-off of 14,000, and dialyze with deionized water for 24 hours to obtain Hybrid single micellar nanoparticles. From figure 2 It can be seen that the present invention successfully prepared ICG-encapsulated hybrid single-micelle nanoparticles (ICG@H-micelle) with a particle size of about 25 nm. From image 3 It can be concluded from the spectrogram that the ICG@H-micelle prepared by the present invention has similar and good optical properties to ICG, and from Figure 4-Figure 6 It can be seen that the ICG@H-micelle obtained by the invention can maintain goo...

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Abstract

The invention belongs to the technical field of nano material preparation, and particularly relates to hybrid single micelle nanoparticles for encapsulating functional molecules and a preparation method of the hybrid single micelle nanoparticles. The preparation method disclosed by the invention comprises the following steps of forming single micelles from a block polymer Pluronic F127 in an aqueous solution, introducing functional molecules, hybridizing the single micelles, and purifying the single micelle nanoparticles. The method is mild in synthesis condition, simple in process, high in universality and low in cost; and the prepared hybrid single micelle nanoparticles have good dispersibility in an aqueous solution, and the size is controllable. Compared with traditional micelles, the hybrid single micelle nanoparticles prepared by the method have higher structural stability and better protectiveness on substances in the micelles, have good biocompatibility and universality, and have good application prospects in the fields of biological imaging, catalysis, treatment and the like.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to hybrid single micellar nanoparticles used for encapsulating functional molecules and a preparation method thereof. Background technique [0002] Due to the complexity of the in vivo environment and the biological safety and hydrophobicity of the material itself, many functional molecules such as imaging probes, hydrophobic drugs, enzymes, etc. cannot be directly delivered to the body. In order to achieve better biological imaging, catalysis, and therapeutic effects, it is of great significance to modify the surface of functional molecules or provide them with transport carriers for their biological applications. [0003] At present, a series of transport vehicles have been developed for the delivery of various functional molecules, such as liposomes, silica nanoparticles, micelles, etc. These nano-carriers effectively enhance the hydrophilicity of the surface o...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/10A61K47/24A61K47/02A61K49/00
CPCA61K9/1641A61K9/1617A61K9/1611A61K49/0034A61K49/0054A61K49/005
Inventor 周乔语赵天聪刘梦丽李晓民
Owner FUDAN UNIV